The Division was conceived to provide support and to encourage clinical trials within NCCS. Since its inception in 1999, it has conducted over 60 trials and accrued over 1300 patients. Besides clinical trials, the division also carries out biostatistical research, epidemiological surveys as well as studies on cancer pharmacology. Other areas of interest include pharmacogenetic studies in our local population and Bayesian statistical methods. CTE also conducts training in clinical trials, as well as being involved in the lecturing and supervision of medical and PhD students from some of the local universities. The division currently has a complement of 20, and works in collaboration with full time clinicians from the clinical departments of NCCS.
There are 3 main sections with the division. These are: 1. Clinical Trials Office 2. Biostatistics Unit3. Epidemiology Unit
We have a team of dedicated staff to support investigators in the areas such as trial co-ordination, budget and project planning, protocol development, negotiation of agreements, ethical and regulatory submissions, case report form design and data discrepancy management. We currently provide the administrative support including providing supervisory manpower and study coordinators to assist the ECRU doctors in running the activities of the ECRU (Experimental Cancer Treatment Unit).
We have more than 18 years of experience in conducting clinical trials and to date, have completed over a hundred clinical trials. Currently we have about 200 ongoing trials. Of particular interests are trials of the new small molecular targeted agents, vaccines, stem-cell mini-transplants and adoptive T cell therapies on the different cancers types such as breast, lung, nasopharynx, stomach, colorectum and liver cancers. Our investigators are constantly in search of new methods and treatments, and actively coming up with new ideas and protocols for clinical testing.
The National Cancer Centre Singapore has obtained Federalwide Assurance from the United States Department of Health and Human Services for human subject protection. This certification allows NCCS to qualify for US Government supported research from CTEP of the US National Cancer Institute.
We have established a study feasibility team that assists the industries and academic institutions in conducting site feasibilities, including review of confidential agreements. The feasibility team facilitates the activities of the NCCS Clinical Trials Steering Committee in selection of clinical trials to be conducted by the centre.
Our research co-ordinators (CRCs) are stringently selected to ensure that they have the aptitude, qualification and interests suitable for the work. Most of our coordinators have at least a degree in medicine, nursing, life or health sciences and have to undergo continuous rigorous training under strict supervision.
Our CRCs worked in teams. The teams specializes in different tumor types. Each team is supervised by 1-2 dedicated team leaders who have the experience and extensive knowledge in clinical trial supervision and training.
We are well-equipped to carry out routine trial procedures for Phase 1 to Phase IV trials. We have the facilities and knowledge to ensure that biological specimens for central laboratories are handled carefully under protocol prescribed conditions. NCCS also has a GMP laboratory for preparing some of our biological agents.
We have dedicated Clinical Trial Pharmacists. The Ambulatory Treatment Unit nurses play an active role as part of the study team to ensure that the administration and handling of study drugs are performed according to the protocol. We are also involved in research areas such as DCE-CT and DCE-MRI. PET and SPECT are available in the campus, and the Nuclear Medicine Department has its own in-house radio-chemist. We also partner the Singhealth Investigational Medicine Unit, which has a 30-bed inpatient unit for early phase trials.
We use the Oracle Clinical Data Management System to manage data. Our team includes a trained system analyst, two data managers and statisticians.
We aim to continue to provide a centralised service for investigators and industries to conduct clinical trials and be a leading centre in clinical trial research. We aim to actively contribute to improving treatment of cancer while also providing patients with novel therapeutic options.
Selected Clinical Trials
Please click here for Selected Clinical Trials list.
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11 Hospital Drive, Singapore 169610 +65 6436 8000