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Publications

Prof N Gopalakrishna IYER

  1. Ong CJ, Shannon NB, Mueller S, Lek SM, Qiu X, Chong FT, Li K, Koh KKN, Tay GCA, Skanthakumar T, Hwang JSG, Lim TKH, Ang MK, Tan DSW, Tan NC, Tan HK, Soo KC, Iyer NG. A three gene immunohistochemical panel serves as an adjunct to clinical staging of patients with head and neck cancer. Oncotarget. 2017 Jun 19. doi: 10.18632/oncotarget.18568. [Epub ahead of print]
  2. See A, Iyer NG, Tan NC, Teo C, Ng J, Soo KC, Tan HK. Distant metastasis as the sole initial manifestation of well-differentiated thyroid carcinoma. Eur Arch Otorhinolaryngol. 2017 Jul;274(7):2877-2882. doi: 10.1007/s00405-017-4532-9. Epub 2017 Apr 5
  3. Ashford BG, Clark J, Gupta R, Iyer NG, Yu B, Ranson M. Reviewing the genetic alterations in high-risk cutaneous squamous cell carcinoma: A search for prognostic markers and therapeutic targets. Head Neck. 2017 Jul;39(7):1462-1469. doi: 10.1002/hed.24765. Epub 2017 Apr 3.
  4. Wong TH, Skanthakumar T, Nadkarni N, Nguyen HV, Iyer NG. Survival of patients with head and neck squamous cell carcinoma by housing subsidy in a tiered public housing system. Cancer. 2017 Jun 1;123(11):1998-2005. doi: 10.1002/cncr.30557. Epub 2017 Jan 30
  5. Jang JH, Tan HK, Iyer NG, Soo KC, Tan NC. Nasopharyngectomy with operating microscope: A case series. Am J Otolaryngol. 2017 Jan - Feb;38(1):82-86. doi: 10.1016/j.amjoto.2016.07.008. Epub 2016 Sep 25.
  6. Ng JH, Iyer NG, Tan MH, Edgren G. Changing epidemiology of oral squamous cell carcinoma of the tongue: A global study. Head Neck. 2017 Feb;39(2):297-304. doi: 10.1002/hed.24589. Epub 2016 Oct 3
  7. Tian B, Iyer NG, Tan HK, Tay AC, Soo KC, Tan NC. Novel technique of creating a seal for the vacuum-assisted closure system application in complex head and neck wounds. Head Neck. 2016 Dec; 38(12):E2523-E2526. doi: 10.1002/hed.24563. Epub 2016 Aug 18.

Professor Pierce Chow

  1. Sharma A, Seow JJW, Dutertre C-A, Pai R, Blériot C, Mishra A, Wong RMM, Naranjan Singh GS, Sudhagar S, Khalilnezhad S, Erdal S, Teo HM, Khalilnezhad A, Chakarov S, Lim TKH, Chung AYF, Kow AWC, Cheow PC, Bonney GK, Goh BKP, Chan JKY, Chow PKH, Ginhoux F, DasGupta R. Onco-fetal reprograming of endothelial cells drivesimmunosuppressive macrophages in Hepatocellular Carcinoma. Cell 2020. doi: 10.1016/j.cell.2020.08.040.
  2. Ding Z, Ericksen R, Escande-Beillard N, Lee QY, Loh A, Denil S, Steckel M, Haegebarth A, Ho SW, Chow PK, Toh HC, Reversade B, Gruenewald S, Han W. Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis. J Hepatology 2020, 72(4): 725-735, doi: 10.1016/j.jhep.2019.10.026.
  3. Huynh H, Lee LY, Goh KY, Ong R, Hao HX, Huang A, Wang Y, Graus PD, Chow P, Chung A. Infigratinib mediates vascular normalization, impairs metastasis, and improves chemotherapy in hepatocellular carcinoma. Hepatology 2019, 69(3): 943-958. doi: 10.1002/hep.30481.
  4. Lim CJ, Lee YH, Pan L, Lai L, Chua C, Wasser M, Lim TKH, Yeong J, Toh HC, Lee SY, Chan CY, Goh BK, Chung A, Heikenwalder M, Ng IO, Chow P, Albani S, Chew V. Multidimensional Analyses Reveal Distinct Immune Microenvironment in Hepatitis B Virus-Related Hepatocellular Carcinoma. Gut 2019, 68(5):916-927. doi:10.1136/gutjnl-2018-316510.
  5. Zhao Y, Shuen TWH, Toh TB, Chan XY, Liu M, Tan SY, Fan Y, Yang H, Lyer SG, Bonney GK, Loh E, Chang KTE, Tan TC, Zhai W, Chan JKY, Chow EK, Chee CE., Lee GH, Dan YY, Chow PK, Toh HC, Lim SG, Chen Q. Development of a New Patient-Derived Xenograft Humanised Mouse Model to Study Human-Specific Tumour Microenvironment and Immunotherapy. Gut 2018, 67(10):1845-1854. doi: 10.1136/gutjnl-2017-315201.
  6. Chow PKH, Gandhi M, Tan SB, Asia-Pacific Hepatocellular Carcinoma Trials, G, et al. Sirvenib: Selective Internal Radiation Therapy Versus Sorafenib in Aisa-Pacific Patients with Hepatocellular Carcinoma. J Clin Oncol 2018, 36:1913-1921. doi: 10.1200/JCO.2017.76.0892.
  7. Zhai W, Lim TK, Zhang T, Phang ST, Tiang Z, Guan P, Ng MH, Lim JQ, Yao F, Li Z, Ng PY, Yan J, Goh BK, Chung AY, Choo SP, Khor CC, Soon WW, Sung KW, Foo RS, Chow PK. The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma. Nature Communications 2017, 8:4565.
  8. Garnelo M, Tan A, Her Z, Yeong J, Lim CJ, Chen J, Lim KH, Weber A, Chow P, Chung A, Ooi LL, Toh HC, Heikenwalder M, Ng IO, Nardin A, Chen Q, Abastado JP, Chew V. Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma. Gut 2017, 66(2):342-351.

Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT)

  1. Lim HJ*, Ong C-AJ*, Skanthakumar T, Mak LYH, Wasudevan SD, Tan JWS, Chia CS, Tan GHC, Teo MCC (* Equal contribution). Retrospective quality of life study in patients with retroperitoneal sarcoma in an Asian population. (2020) Health Qual Life Out. PubMed ID: 32762683.
  2. Ong C-AJ*, Lim HJ*, Tan JWS, Wong JSM, Lim ST, Kwek JW, Tan HK, Hwang WYK, Chia CS (* Equal contribution). Facilitating timely cancer care in a surgical oncology subspecialty unit during the pandemic and recovery phase of the COVID era. (2020) Asian J Surg. PubMed ID: 32713751.
  3. Wong JSM, Tan GHC, Chia CS, Ong CAJ, Teo MCC. Management of Synchronous Lateral Pelvic Nodal Metastasis in Rectal Cancer in the era of Neoadjuvant Chemoradiation: A Systemic Review. (2020) World J Gastrointest Surg. 12(5): 247-258. PubMed ID: 32551030.
  4. Qu X, Zhao H, Natalia A, Lim CZJ, Ho NRY, Ong C-AJ, Teo MCC, So JBY, Shao H. Exosome-templated nanoplasmonics for multiparametric molecular profiling. (2020) Sci Adv 6(19): eaba2556. PubMed ID: 32494726.
  5. Tan G, Wong J. Surgical management and hyperthermic intraperitoneal chemotherapy for locally advanced colorectal cancer. (2020) J Gastrointest Oncol. 11(3): 508-512. PubMed ID: 32655929.
  6. Ragavan S*, Lim HJ*, Tan JWS, Hendrikson J, Chan JY, Farid M, Chia CS, Tan GHC, Soo KC, Teo MCC, Ong C-AJ (* Equal contribution). Axillary Lymph Node Dissection in Angiosarcomas of the Breast: An Asian Institutional Perspective. (2020) Sarcoma 2020: 4890803. PubMed ID: 32300278.
  7. Chin KM, Tan GHC, Chia CS, Ong JCA, Teo MCC. Novel prognostic score for outcomes after cytoreductive surgery and HIPEC for colorectal cancer with metachronous peritoneal carcinomatosis. (2020) ANZ Journal of Surgery doi:10.1111/ans.15783. PubMed ID: 32159299.
  8. Ong CAJ, Smith MA, Snow HA, Benson C, Jones RL, Hayes AJ, Strauss DC. Primary iliocaval leiomyosarcomas: The path beyond surgery. (2020) Eur J Surg Oncol. 46(5): 893-897. PubMed ID: 32067874.
  9. Ong CAJ*, Tan QX*, Lim HJ*, Shannon NB, Lim WK, Hendrikson J, Ng WH, Tan JWS, Koh KKN, Wasudevan SD, Ng CCY, Rajasegaran V, Lim TKH, Ong CK, Kon OL, Teh BT, Tan GC, Chia CS, Soo KC, Teo MCC (*Equal contribution). An optimised protocol harnessing laser capture microdissection on matched primary and metastatic colorectal tumours. (2020) Sci Rep 10:682. PubMed ID: 31959771.
  10. Wong J, Tan G, Chia CS, Ong J, Ng WY, Teo MCC. The Importance of Synchronicity in the Management of Colorectal Peritoneal Metastases with Cytoreductive Surgery & Hyperthermic Intraperitoneal Chemotherapy. (2020) World J Surg Oncol 18:10. PubMed ID: 31931817.

DSSO Breast Team:

  1. Chan JJ, Sim Y, Ow SGW, Lim JSJ, Kusumawidjaja G, Zhuang Q, Wong RX, Wong FY, Tan VKM, Tan TJY. The impact of COVID-19 on and recommendations for breast cancer care: the Singapore experience. Endocr Relat Cancer. 2020 Sep; 27(9): R307-R327. doi: 10.1530/ERC-20-0157. 
  2. Ho WK, Tan MM, Mavaddat N, Tai MC, Mariapun S, Li J, Ho PJ, Dennis J, Tyrer JP, Bolla MK, Michailidou K, Wang Q, Kang D, Choi JY, Jamaris S, Shu XO, Yoon SY, Park SK, Kim SW, Shen CY, Yu JC, Tan EY, Chan PMY, Muir K, Lophatananon A, Wu AH, Stram DO, Matsuo K, Ito H, Chan CW, Ngeow J, Yong WS, Lim SH, Lim GH, Kwong A, Chan TL, Tan SM, Seah J, John EM, Kurian AW, Koh WP, Khor CC, Iwasaki M, Yamaji T, Tan VKM, Tan BKT, Spinelli JJ, Aronson KJ, Hasan SH, Rahmat K, Vijayananthan A, Sim X, Pharoah PDP, Zheng W, Dunning AM, Simard J, van Dam RM, Y CH, Mohd Taib NA, Hartman M, Easton DF, Teo SH, Antoniou AC. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nat Commun. 2020 Jul 31; 11(1): 3833. doi: 10.1038/s41467-020-17680-w.
  3. Wong RX, Kusumawidjaja G, Tan V. Solitary contralateral axillary metastasis in breast cancer: Is it a true distant spread? Breast J. 2020 Jul; 26 (7): 1493-1494. doi: 10.1111/tbj.13733. Epub 2019 Dec 26.
  4. Ngaserin S, Chua HW, Chew MH, Tan BKT. A tripartite approach can seek to optimize breast cancer management during a pandemic - Real-Time experience of a developing breast oncology unit in Singapore. Breast J. 2020 Jul 1. doi: 10.1111/tbj.13961. Online ahead of print.
  5. Ngaserin S, Tan BKT. Smoke evacuation in endoscopic breast surgery can enhance operative visualization and respect surgical safety. Breast J. 2020 Jun 17. doi: 10.1111/tbj.13941. Online ahead of print.
  6. Kee GJ, Tan RYC, Rehena S, Lee JJX, Zaw MWW, Lian WX, Yeong J, Tan SM, Lim SH, Tan BKT, Yap YS, Dent RA, Wong FY, Lee GE. Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience. World J Clin Oncol. 2020 May 24; 11(5): 283-293. doi: 10.5306/wjco.v11.i5.283.
  7. Tay THC, Ng WY, Ong KW, Wong CY, Tan BKT, Yong WS, Madhukumar P, Tan VKM, Lim SZ, Sim Y. Impact of hormonal status on ductal carcinoma in situ of the breast: Outcome and prognostic factors. Breast J. 2020 May;26(5):937-945. doi: 10.1111/tbj.13738. Epub 2019 Dec 26.
  8. Hamzah JLB, Tan BKT, Tan VK, Madhukumar P, Lim SZ, Sim Y, Yong WS, Lee ZJ, Ong KW. A pilot study comparing Sentimag/Sienna versus standard modality for sentinel lymph node identification in patients with breast cancer. Breast J. 2020 May; 26(5): 1074-1077. doi: 10.1111/tbj.13660. Epub 2019 Oct 14.
  9. Tang CYL, Lam WWC, Tan PH, Xie W, Peh WM, Tan VKM, Leong LCH. Myoepithelial hyperplasia: A rare mimic of breast cancer on (18) F-FDG PET/CT. Breast J. 2020 Apr;26(4):775-777. doi: 10.1111/tbj.13643. Epub 2019 Sep 28.
  10. Ho PJ, Ow SGW, Sim Y, Liu J, Lim SH, Tan EY, Tan SM, Lee SC, Tan VK, Yap YS, Chay WY, Tan BKT, Wong FY, Li J, Hartman M. Impact of deviation from guideline recommended treatment on breast cancer survival in Asia. Sci Rep. 2020 Jan 28;10(1):1330. doi: 10.1038/s41598-020-58007-5.
  11. Nasir NDM , Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VK, Wong CY, Yong WS, Ho GH, Ong KW. International Fibroepithelial Consortium, Patrick Tan P, Teh BT, Tan PH. Genomic characterisation of breast fibroepithelial lesions in an international cohort. J Pathol. 2019 Dec; 249(4): 447-460. doi: 10.1002/path.5333. Epub 2019 Oct 8.
  12. Hamzah JL, Ong KW, Tan BY. Isolated invasive ductal carcinoma of the nipple‐areolar complex: A rare occurrence yet to be reported in current literature. Breast J. 2019;00:1–3. https://doi.org/10.1111/tbj.13308.
  13. Tison RT, Leong L, Tan PH, Tan VKM. Extensive Florid Lobular carcinoma in situ presenting as a large breast mass requiring a mastectomy. Wiley The Breast Journal 2019 Nov; DOI: 10.1111/tbj.13705.
  14. Loke SY, P Munusamy, Koh GL, Chan CHT, P Madhukumar, Thung JL, Tan BKT, Ong KW, Yong WS, Sim Y, Oey CL, Lim SZ, Chan PMY, Ho JTS, Khoo JBK, Wong JSL, Thng CH, Chong BK, Tan EY, Tan VKM, Lee ASG. A circulating miRNA signature for stratification of breast lesions among women with abnormal screening mammograms. Cancers (Basel). 2019 Nov 26; 11(12): 1872. doi: 10.3390/cancers11121872.
  15. Gambre AS, Tan PH, Hamzah JLB, Leong LCH. Rare case of bilateral male breast myofibroblastomas with radio‐pathological correlation. Wiley The Breast Journal 2018 Oct; DOI: 10.1111/tbj.13405.
  16. Sim Y, Ng GXP, Ng CCY, Rajasegaran V, Wong SF, Liu W, Guan P, Nagarajan S, Ng WY, Thike AA, Lim JCT, Nasir NDB, Tan VK, Madhukumar P, Yong WS, Wong CY, Tan BKT, Ong KW, Teh BT, Tan PH. A Novel Genomic Panel as an Adjunctive Diagnostic Tool for the Characterization and Profiling of Breast Fibroepithelial Lesions. BMC Medical Genomics. 2019 Oct 23; 12(1): 142. doi: 10.1186/s12920-019-0588-2.
  17. Hamzah JLB, Tan VKM. Fulminant gas‐forming breast abscess associated with synergistic Veillonella infection. Breast J. 2019 May 10;00:1–3. https ://doi.org/10.1111/tbj.13453.
  18. CH Lin, YS Yap, KH Lee, SA Im, Y Naito, W Yeo, T Ueno, A Kwong, HP Li, SM Huang, R Leung, W Han, B Tan, FC Hu, CS Huang, AL Cheng, YS Lu; The Asian Breast Cancer Cooperative Group. Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians versus the US Population. J Natl Cancer Inst. 2019 Dec 1; 111(12): 1298-1306. doi: 10.1093/jnci/djz090.
  19. Xiang F, Gogna A, Leong LCH, Tan BKT. Pseudoaneurysm after vacuum-assisted breast biopsy treated with percutaneous thrombin injection. Breast J. 2019 ar; 25(2): 318-319. doi:10.1111/tbj.13213. Epub 2019 Feb 7.
  20. Basu P, Leong LCH, Tan BY, Tan BKT. Breast Calcifications in patients with end-stage renal disease. 2019 Wiley Periodicals, Inc. DOI: 10.1111/tbj.13272.
  21. Lim SZ, Ng CCY, Rajasegaran V, Guan P, Selvarajan S, Thike AA, Md Nasir D, Koh VCY, Tan BKT, Ong KW, Teh BT, Tan PH. Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours. Breast Cancer Research and Treatment (2019) 174:365–373. Doi: 10.1007/s10549-018-5067-5.
  22. Koh VCY, Lim JCT, Thike AA, Cheok PY, Myint Thu MM, Li H, Tan VKM, Ong KW, Tan BKT, Ho GH, Thilagaratnam S, Wong JSL, Wong FY, Ellis IO, Tan PH. Behaviour and characteristics of low-grade ductal carcinoma in situ of the breast: literature review and single-centre retrspective series. Histopathology. 2019 Jun; 74(7): 970-987. doi: 10.1111/his.13837. Epub 2019 Mar 28.
  23. Sim Y, Tan VKM, Sidek NAB, Chia DKA, Tan BKT, Madhukumar P, Yong WS, Wong CY, Ong KW. Bilateral breast cancers in an Asian population, and a comparison between synchronous and metachronous tumours. ANZ J Surg. 2018 Oct; 88(10): 982-987. doi: 10/1111/ans.14773. Epub 2018 Aug 23.
  24. Lee CM, Zheng H, Tan VK, Tan TJ, Kanesvaran R, Wong FY, Sim YR, Yong WS, Madhukumar P, Ong KW, Tan BK. Surgery for early breast cancer in the extremely elderly leads to improved outcomes-An Asian population study. Breast. 2017 Dec 36:44-48. doi: 10.1016/j.breast.2017.09.002. Epub 2017 Sep 22.
  25. SH Chun Cheng, TT Huang, YH Cheng, BKT Tan, CF Horng, YA Wang, NS Brian, LS Shih, BL Yu. Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer. PLOS ONE. 2017 Sep 8;12(9):e0184372. doi: 10.1371/journal.pone.0184372. eCollection 2017.
  26. Lim SZ, Selvarajan S, Thike AA, Nasir D, Tan BKT, Ong KW, Tan PH. Breast sarcomas and malignant phyllodes tumours: comparison of clinicopathological features, treatment strategies, prognostic factors and outcomes. Breast Cancer Res Treat. 2016 Sep;159(2):229-44. DOI 10.1007/s10549-016-3946-1. Epub 2016 Aug 19.
  27. Tan J, Ong CK, Lim WK, Ng CC, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BH, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Ahmad BS, Iau P, Chan CW, Tang AP, Yong WS, Madhukumar P, Ho GH, Tan VK, Wong CY, Hartman M, Ong KW, Tan BK, Rozen SG, Tan P, Tan PH, Teh BT. Genomic landscapes of breast fibroepithelial tumors. Nat Genet. 2015 Nov;47(11):1341-5. doi: 10.1038/ng.3409.