Our Research | National Cancer Centre Singapore

Title of Study	Contact Investigator	Status
Real-world assessment of treatment outcomes in HR+HER2- EBC during pre-adjuvant CDK4/6 inhibitor era in Singapore (2025)	Dr Ma Jun Dr Elaine Lim	Ongoing Abstract
Institutional review on patients with T1-3N1M0 breast cancer who had post mastectomy radiotherapy (PMRT) and axillary lymph node dissection (ALND) (2024)	Dr Lim Sue Zann	Ongoing Abstract
Benefit of primary tumour resection in de novo oligometastatic breast cancer – a multicenter retrospective cohort study (2024)	Dr Shi Hui Yang Dr Sim Yirong	Ongoing Abstract
Long term conditional survival rates of breast cancer patients in Singapore and its significance for a community based share care model for breast cancer survivorship (2024)	Dr Jeffrey Hing Prof Tan Su-Ming	Ongoing Abstract
The role of B3 diagnosis as a Risk Factor for future breast cancer development (2024)	Dr Li Jingmei Dr Wong Fuh Yong	Ongoing Abstract
Real-World Outcomes of Trastuzumab Deruxtecan in Patients with Metastatic Breast Cancer: A Single-Centre Study (2024)	Dr Lee Han Yi Shih Vivianne Dr Tan Jing Ying Tira	Ongoing Abstract
Multimodal Integration of Data for Breast Cancer Risk Prediction (2024)	Dr Wong Fuh Yong Dr Ryan Ying-Cong Tan	Ongoing Abstract
Clinicopathological characteristic of HER2 low breast cancers in the Singapore population (2023)	Dr Mihir Gudi	Ongoing Abstract
Inflammatory breast cancer in Singapore and validation of a diagnostic score (2023)	Dr Sim Yirong	Ongoing Abstract
Economic evaluation of a risk-based breast cancer screening approach in Singapore (2023)	Dr Wong Fuh Yong Dr Li Jingmei	Ongoing Abstract
Patient characteristics and breast cancer outcomes (2023)	Dr Ryan Ying-Cong Tan	Ongoing Abstract
Assessing the effect and outcome of axillary radiotherapy in patients with cN0 disease who are then yN0 but have evidence of treatment effect in the nodes post neoadjuvant chemotherapy on sentinel lymph node biopsy (2023)	Dr Faye Lim	Ongoing Abstract
Review of ductal carcinoma in-situ and invasive carcinoma in breast fibroepithelial lesions (2022)	Dr Tan Si Ying	Ongoing Abstract
BCS vs mastectomy: Long-term efficacy for primary operable in-situ and early stage breast cancers (2022)	Dr Sabrina Ng	Ongoing Abstract
A study to evaluate clinical-radiological-pathological concordance in patients with invasive lobular carcinoma of the breast (2022)	Dr Sabrina Ng	Ongoing Abstract
A quantitative and qualitative study of factors influencing delayed presentation, diagnosis and treatment of breast cancer patients who present with locally-advanced or metastatic disease (2022)	Dr Sabrina Ng	Ongoing Abstract
Encysted papillary carcinoma of the breast: an institutional case series and literature review (2021)	Dr Sim Yirong	Ongoing Abstract
Use of cyclin-dependent kinase (CDK) 4/6 inhibitors in treatment of metastatic breast cancer patients in Singapore (2021)	Dr Lim Hsuen Elaine	Ongoing Abstract
Improving Breast Cancer Risk Prediction in Singapore Women with a Hybrid Machine-Learning Model (2021)	Dr Ryan Ying-Cong Tan Dr Veronique Tan Dr Wong Fuh Yong	Ongoing Abstract
AI-driven Survival Modelling in Breast Cancer (2021)	Dr Wong Fuh Yong	On-going Abstract
Survival outcomes of Advanced Breast Cancer Patients in Singapore (2020)	Dr Rachel Sim Hui Zhen Dr Yap Yoon Sim	On-going Abstract
PREoperative therapy and Supportive Care in EarLy & Locally Advanced breast cancers – PreSCella	Dr Tira Tan Jing Ying	On-going
Investigating the role and impact of discordant hormone receptor status in newly diagnosed breast cancer patients	Dr Grace Kusumawidjaja	On-going Abstract
Retrospective review of imaging findings and surveillance outcomes after oncoplastic breast conserving surgery	Dr Lester Leong Chee Hao	On-going Abstract
Curative Approaches for Metaplastic Breast Cancer: A Retrospective Cohort Outcome Review. Int J Radiat Oncol Biol Phys. 2024 Jun 29:S0360-3016(24)00751-X. doi: 10.1016/j.ijrobp.2024.06.016. Ling Fung Nelson Yit, Zhan Hong Sheriff Quek, Tira J Tan, Boon Fei Tan, Puay Hoon Tan, Kiat Tee Benita Tan, Yirong Sim, Fuh Yong Wong.	Dr Nelson Yit Ling Fung	Abstract
Long-Term Oncologic Outcomes of Omitting Axillary Surgery in Breast Cancer Patients with ChestWall Recurrence afterMastectomy. Cancers 2024, 16,2699. https://doi.org/10.3390/cancers16152699. Lim GH, Alcantara VS., Allen JC, Saffari SE, Tan VKM,Tan KTB, Ngaserin S, Tan SM, Leong LCH, Wong FY.	Dr Lim Geok Hoon	Full text
Outcomes in Nonmetastatic Hormone Receptor–Positive HER2-Negative Pure Mucinous Breast Cancer:A Multicenter Cohort Study. J Natl Compr Canc Netw 2024;22(2D):e237121.doi:10.6004/jnccn.2023.7121. Ryan Ying Cong Tan, Whee Sze Ong, Kyung-Hun Lee,Seri Park,Jabed Iqbal,Yeon Hee Park, Jeong Eon Lee, Ching-Hung Lin,Yen-Shen Lu,Makiko Ono,Takayuki Ueno, Yoichi Naito, Tatsuya Onishi,Geok-Hoon Lim,Su-Ming Tan,Han-Byoel Lee, Jiwon Koh, Wonshik Han,Seock-Ah Im,Veronique Kiak Mien Tan, Nitar Phyu, Fuh-Yong Wong, Puay Hoon Tan,and Yoon-Sim Yap.	Dr Ryan Ying-Cong Tan	Full text
Correlation of Neutrophil-Lymphocyte and Albumin-Globulin Ratios With Outcomes in Patients With Breast Cancer Undergoing Neoadjuvant Chemotherapy or Upfront Surgery. J Breast Cancer. 2024 Apr;27(2):e9. https://doi.org/10.4048/jbc.2023.0242. Yang SH, Tey Min Li, Zhou Siqin, Phyu Nitar, Hanis M, Sim Yirong, Grace K, Chay WY, Wong FY, Wong RX.	Dr Shi Hui Yang	Full text
Determining the Need for Metastatic Staging in Patients with Bilateral Breast Cancers. Curr. Oncol.2024, 31, 1936–1946. https://doi.org/10.3390/curroncol31040145. Alcantara VS, Chan SMZ, Wong FY, Allen JC, Lim GH.	Dr Lim Geok Hoon	Full text
How Asian Breast Cancer Patients Experience Unequal Incidence of Chemotherapy Side Effects: A Look at Ethnic Disparities in Febrile Neutropenia Rates. Cancers 2023, 15, 3590. https://doi.org/10.3390/cancers15143590. Lim ZL, Ho PJ, Hartman M, Tan ET, Riza NKBM; Lim EH; Nitar P; Joint Breast Cancer Registry (JBCR); Wong FY; Li J.	Dr Li Jingmei Dr Lim Hsuen Elaine	Full text
Modern-era radiotherapy and ischaemic heart disease-related mortality outcomes in Asian breast-cancer patients. Contemp Oncol (Pozn) 2022; 26 (1): 59–68. Ling Fung Nelson Yit, Choon Ta Ng, Fuh Yong Wong, Zubin Master, Siqin Zhou, Wee Loon Ng.	Dr Ng Wee Loon	Full text
Male breast cancer: a Singapore perspective. ANZ J Surg 2022; 92(6):1440-1446. Joshua S. H. Lim, Yirong Sim, Joanne Ngeow,Jeanette Yuen, Veronique K. M. Tan, Benita Kiat Tee Tan, Wei-Sean Yong, Chow Yin Wong,Sue Zann Lim, Julie Liana B. Hamzah,Si Ying Tan,Fuh Yong Wong, Preetha Madhukumar.	Dr Joshua Lim Sheng Hao	Full text
The Impact of Statin Use and Breast Cancer Recurrence - A Retrospective Study in Singapore. Front. Oncol. 2022 Front. Oncol. 2022; 12: 835320. Sim Y, Lim C, Phyu N, Tan KTB, Chew LST, Wong CY, Madhukumar P, Yong WS, Lim SZ, Hamzah JLB, Tan SY, Chay WY, Wong FY, Tan PH,Tan VKM.	Dr Sim Yirong	Full text
HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis. BMC Med 2022; 20: 105. Tan R, Ong WS, Lee KH, Lim AH, Park S, et al.	Dr Ryan Ying-Cong Tan	Full text
Multi-center evaluation of artificial intelligent imaging and clinical models for predicting neoadjuvant chemotherapy response in breast cancer. Breast Cancer Res Treat 2022; 10.1007/s10549-022-06521-7. Tan HQ, Hian OH, Kumaran AM, Tan TJ, Cong TRY, et al.	Dr Nei Wen Long	Full text
Effects of housing value and medical subsidy on treatment and outcomes of breast cancer patients in Singapore: A retrospective cohort study. The Lancet Regional Health - Western Pacific 6 (2021) 10 0 065. F.Y. Wong, R.X. Wong, S. Zhou et al.	Dr Wong Fuh Yong	Full text
Contrasting Epidemiology and Clinicopathology of Female Breast Cancer in Asians vs the US Population. J Natl Cancer Inst. 2019 Dec 1;111(12):1298-1306. Lin CH, Yap YS, Lee KH, Im SA, Naito Y, Yeo W, Ueno T, Kwong A, Li H, Huang SM, Leung R, Han W, Tan B, Hu FC, Huang CS, Cheng AL, Lu YS; Asian Breast Cancer Cooperative Group.	Dr Yap Yoon Sim	Full text
The impact of radiotherapy and histological risk factors on outcomes in malignant phyllodes tumors. Clin Breast Cancer. 2020 Dec;20(6):e695-e700. Wong RX, Koh YS, Wong FY, Kusumawidjaja G, Ng WL, Yeo RMC, Farid M, Sheng, Chan JY, Yan Z, Gudi MA, Tan PH	Dr Wong Ru Xin	Abstract Full text
Human epidermal growth factor receptor 2 positive rates in invasive lobular breast carcinoma: The Singapore experience. World J Clin Oncol 2020; 11(5): 283-293. Ga-Jing Kee, Ryan Ying-Cong Tan, Sultana Rehena, Joycelyn Jie-Xin Lee, Ma Wai-Wai Zaw, Wei-Xiang Lian, Joe Yeong, Su-Ming Tan, Swee-Ho Lim, Benita Kiat-Tee Tan, Yoon-Sim Yap, Rebecca Alexandra Dent, Fuh-Yong Wong, Guek-Eng Lee	Dr Ryan Ying-Cong Tan	Full text
Patterns of relapse after neoadjuvant chemotherapy in breast cancer: implications for surveillance in clinical practice. Breast Cancer Res Treat. 2019 Aug;177(1):197-206. Saw S, Lim J, Lim SH, Wong M, Lim C, Yap YS	Dr Yap Yoon Sim	Abstract Full text
Validation of Modified Breast Graded Prognostic Assessment for breast cancer patients with brain metastases: extra-cranial disease progression is an independent risk factor. Ann Palliat Med 2019;8(4):390-400. Qingyuan Zhuang, Ru Xin Wong, Wei Xiang Lian, You Quan Li, Fuh Yong Wong	Dr Zhuang Qingyuan	Full text
Pregnancy associated breast cancer: a multicenter study comparing clinicopathological factors, diagnosis and treatment outcomes with non pregnant patients. Breast Cancer Research and Treatment (2023) 198:53–66. https://doi.org/10.1007/s10549-022-06855-2. Qing Ting Tan, Veronica Siton Alcantara, Rehena Sultana, Kiley Wei‑Jen Loh, Aura Lynn Go, Fuh Yong Wong	Dr Tan Qing Ting	Full text
Breast cancer anatomic staging with biological risk Score is effective and simple to use. Melbourne International Breast Conference Oct 2018. WX Lian, RX Wong, YH Seow, YS Yap, JHC Lim, FY Wong	Dr Wong Ru Xin	Full text
Validation of the AJCC 8th prognostic system for breast cancer in an Asian healthcare setting. Breast. 2018 Apr 17;40:38-44. Wong RX, Wong FY, Lim J, Lian WX, Yap YS	Dr Wong Ru Xin	Abstract Full text
Surgery for early breast cancer in the extremely elderly leads to improved outcomes - An Asian population study. Breast. 2017 Dec; 36:44-48. Lee CM, Zheng H, Tan VK, Tan TJ, Kanesvaran R, Wong FY, Sim YR, Yong WS, Madhukumar P, Ong KW, Tan BK	A/Prof Benita Tan Kiat Tee	Abstract Full text
Screening uptake differences are not implicated in poorer breast cancer outcomes among Singaporean malay women. J Breast Cancer. 2017 Jun;20(2):183-191. Wong Ru Xin, Li-lian Kwok, Wong Fuh Yong	Dr Wong Ru Xin	Full text
Outcome after neoadjuvant chemotherapy in Asian breast cancer patients. Cancer Med. 2017 Jan; 6(1): 173–185. Li Yan Lim, Hui Miao, Joline S.J.Lim, Soo Chin Lee, Nirmala Bhoo-Pathy, Cheng Har Yip, Nur Aishah B.M.Taib, Patrick Chan, Ern Yu Tan, Swe Ho Lim, Geok Hoon Lim, Evan Woo, Yia Swam Tan, Jung Ah Lee, Mabel Wong, Puay Hoon Tan, Kong Wee Ong, Fuh Yong Wong, Yoon Sim Yap, Mikael Hartman	Dr Yap Yoon Sim	Full text
Clinicopathological characteristics and treatment outcomes in patients with stage I-III invasive Lobular carcinoma of the breast (ILC) treated at the National Cancer Centre Singapore. 2016 ASCO Annual Meeting. J Clin Oncol 2016 suppl; abstr. Joycelyn Jie Xin Lee, Fuh-Yong Wong, Benita Tan, Swee Ho Lim, Sze Huey Tan, Joanne YY Ngeow, Rebecca Alexandra Dent	Dr Joycelyn Jie Xin Lee	Abstract
Prognostic role of adjuvant radiotherapy in triple-negative breast cancer: A historical cohort study.Int J Cancer. 2015 Nov 15;137(10):2504-12. Bhoo-Pathy N, Verkooijen HM, Wong FY, Pignol JP, Kwong A, Tan EY, Aishah Taib N, Nei WL, Ho GF, Tan B, Chan P, Lee SC, Hartman M, Yip CH, Dent R	Dr Rebecca Alexandra Dent	Full text