Dr. Lee Jin LIM
Yong Zher KOH
Jun Yan LOH
Ashley LIM Jun Wei
Tyniana Carissa Tera
Laura GOH Shih Hui
There are three major focus in the Liver Cancer Functional Genomics Laboratory. The first is to understand the role of chronic inflammation in tumorigenesis for the development of intervention strategies. Our laboratory has identified FAT10 as a molecule that plays an important role in Hepatocellular Carcinoma and other cancers associated with chronic inflammation. We seek to further elucidate its role in modulating inflammation and metabolism during tumorigenesis and metastasis to facilitate the development of strategies targeting this molecule.
The second major focus of the laboratory is to elucidate the role of various non-coding RNAs (including circular RNA, microRNAs and long noncoding RNAs) in hepatocellular carcinoma. Our laboratory has employed an integrative big data approach to identify clinically relevant networks of non-coding RNAs in the cancer pathway. We will characterise these networks of non-coding RNAs for their tumorigenic potential to identify novel molecular biomarkers that can be used to help detect liver cancer at an early stage more accurately, predict patient responses to specific treatments, and identify targets for therapy.
The third major focus is in the field of Precision Medicine, where the laboratory aims to employ biologically meaning artificial intelligence (AI) and machine learning to better predict complex disease susceptibility, drug response and prognosis.
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