Ng Wai Har
Tan Qiu Xuan
Zhu Hong Yuan
Prof Soo Khee Chee
Clinical A/Prof Claramae Chia Shulyn
Dr Jolene Wong
Dr Jane Seo Chin Jin
The Laboratory of Applied Human Genetics was conceived in 2013 under the leadership of Assistant Professor Ong. Assistant Prof Ong pursued his PhD at the University of Cambridge, UK, as an NRF-MOH Research Scholar in 2009. As a returning scientist with an aspiration to become a surgeon–scientist, he quickly resumed cancer research and has been under the mentorship of Prof. Kon since 2016.
Our laboratory is an interdisciplinary laboratory, with a specific focus on peritoneal and sarcoma malignancies. The dual-hatting of surgeon–scientists in the Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT) gives our laboratory an intrinsic advantage by combining our clinical practice with laboratory research, effectively paving the way for bench-to-bedside translational research. We are a group of young and enthusiastic team of researchers with a vision of making an impact on patients’ lives through sound scientific research and to harness technology to transit scientific research to clinical care beyond proof of concept. Our laboratory’s area of expertise harnesses this advantage, allowing for a) multi-sampling of surgically collected samples to correct for intra-tumoral heterogeneity, b) rapid transfer of tissues to prevent degradation, and c) generation of
in vivo mouse models of human samples. Our approach to solving clinical questions with translational relevance and addressing hypotheses is illustrated in Figure 1.
There are three main pillars to our laboratory - translational therapeutics, innovation and academic pursuits.
The research that our laboratory has been tirelessly working on for the past 7 years was published in Cell Reports Medicine and was selected as one of the flagship articles for the February 2022 issue, with its message featured as the cover image of the reputable journal. We detail the identification of a key paracrine factor (PAI-1) found within the fluid microenvironment of the peritoneal cavity, which can be directly targeted via ligand inhibition, providing proof of concept of therapeutic perturbation in peritoneal carcinomatosis (Hendrikson et al., 2022). Building upon this, we have also included paracrine inhibition as a key therapeutic strategy in tackling peritoneal carcinomatosis in our review article in
Journal of Clinical Oncology (Gwee et al., 2022).
Our work in the use of biomarkers for molecular stratification of peritoneal carcinomatosis patients to predict response to PAI-1 ligand inhibition have also been filed for a Patent Cooperation Treaty (PCT) application (PCT/SG2020/050177) in March 2020, and is currently in the National phase review in 5 countries (China, USA, Europe, Singapore and Taiwan).
Academically, our team has published extensively in the field of peritoneal disease and sarcomas. To date, we have published more than 30 articles including publications in high impact factor or Top 10 and 20% journals such as
Nature Communications, Journal of Clinical Oncology, npj Precision Oncology, Oral Oncology, Annals of Surgical Oncology and European Journal of Surgical Oncology. We are also highly committed in nurturing the next generation of scientists and clinician scientists. Within our laboratory, we have formulated an informal program to stimulate the interests of surgical residents and junior doctors to pursue scientific research that can accommodate their hectic schedules. We have had significant success in this area; we have mentored more than 30 residents, junior doctors and medical students, many of which have published in Top 10/ 20% journals and presented in local and international conferences by working together with us.
As part of our efforts to push the frontiers of translational science, we actively seek collaborations with numerous disciplines and institutions to synergize our strengths in different expertise. To this end, we have established several scientific collaborations to advance our research, including Singapore Gastric Cancer Consortium, Duke-NUS Medical School, BIGHEART (NUS), Department of Biochemistry (NUS), EDDC (A*STAR), IMCB (A*STAR) and GIS (A*STAR). We are also one of the founding members of the Singapore Peritoneal Oncology Study (SPOS) Group, which was set up to address the multiple challenges in the management of patients with peritoneal carcinomatosis in Singapore. These collaborations will further enhance the three pillars of our laboratory, i.e. translational therapeutics, innovation and academic pursuits.
Grants and Awards
Since the inception of our laboratory, we have been awarded 20 grants, including five national grants from National Medical Research Council (NMRC), Experimental Drug Development Centre (EDDC) in A*STAR and National Health Innovation Centre (NHIC). Our team is also part of the Singapore Gastric Cancer Consortium (SGCC), which was awarded $25 million under the Open Fund-Large Collaborative Grant programme in 2019. Our PI, Assistant Prof Ong, was also awarded the NMRC Clinician Scientist-Individual Research Grant (CS-IRG) in 2021. The team has received numerous awards, including International Conference Travel Award, Best Oral Presentation Award, Young Investigator Award, Distinguished Young Researcher Award and an NMRC Transition Award.
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11 Hospital Crescent, Singapore 169610 +65 6436 8000