Ng Wai Har
Tan Qiu Xuan
Prof Soo Khee Chee
Adj. A/Prof Claramae Chia Shulyn
Adj. A/Prof Tan Hwei Ching Grace
Dr Jolene Wong
Dr Eliza Sin
The Laboratory of Applied Human Genetics was conceived in 2013 under the leadership of Asst. Prof. Ong. Prof. Ong pursued his PhD at the University of Cambridge, UK, as an NRF-MOH Research Scholar in 2009. As a returning scientist with an aspiration to become a surgeon–scientist, he quickly resumed cancer research and has been under the mentorship of Prof. Kon since 2016.
Our laboratory is an interdisciplinary laboratory, with a specific focus on peritoneal and sarcoma malignancies. The dual-hatting of surgeon–scientists in the Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT) gives our laboratory an intrinsic advantage by combining our clinical practice with laboratory research, effectively paving the way for bench-to-bedside translational research. Our laboratory’s area of expertise harnesses this advantage, allowing for a) multi-sampling of surgically collected samples to correct for intra-tumoral heterogeneity, b) rapid transfer of tissues to prevent degradation, and c) generation of in vivo mouse models of human samples. Our approach to solving clinical questions with translational relevance and addressing hypotheses is illustrated in Figure 1.
Since its inception, our laboratory has been awarded seven grants, including two National Medical Research Council (NMRC) grants. The team has also received numerous awards, including International Conference Travel Award, Best Oral Presentation Award, Young Investigator Award, Distinguished Young Researcher Award, and an NMRC Transition Award.
As part of our collaborative efforts to push the frontiers of translational science, we actively seek collaborations with numerous disciplines and institutions to synergize our strengths in different expertise. Remarkedly, our team is part of the Singapore Gastric Cancer Consortium (SGCC), which was awarded $25 million under the Open Fund-Large Collaborative Grant programme in 2019.
Despite our infancy, we have two publications with an impact factor >4 and two manuscripts currently under review. Our team’s present work is expected to be published in the next 18 months in a journal with an impact factor >10.
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11 Hospital Crescent, Singapore 169610 +65 6436 8000