Skip Ribbon Commands
Skip to main content


Drug Class: Commonly Known As: Category:

Prochlorperazine - What is it for

​Prochlorperazine is a type of anti-emetic agent which blocks dopamine (a type of chemical messenger). By blocking dopamine, signals are unable to travel to the vomiting center in the brain, therefore relieving the sensation of nausea (feeling sick) and vomiting on its own or nausea and vomiting due to other causes such as Meniere disease or inner ear problems for example vertigo (giddiness).

Prochlorperazine - Side Effects, Precautions, and Contraindications

What side effects can Prochlorperazine cause?

  • ​Constipation
    • Drink more water (if not fluid restricted), eat more high fibre foods
  • Dry mouth
  • Chew sugar-free gum, suck on sugar-free hard candies or ice chips, sip water regularly
    • Dry eyes 
  • Use a lubricating eye drop
    • Light-headedness (especially during a sudden change in posture)
    • Get up slowly from sitting or lying down position
      • Feeling tired or drowsy 
    • Avoid driving or engaging in activities requiring concentration 

    Before taking Prochlorperazine , what precautions must I follow?

    ​Inform your healthcare professional if: 

    • You are allergic to this medication or any of the other ingredients of this medication
    • You are pregnant, planning to become pregnant, or breastfeeding
    • You are taking any other medications, including supplements, traditional medications and herbal remedies
    • Medical conditions such as heart disease, dementia, liver and kidney disease, seizure (fits), phaeochromocytoma (tumour on the adrenal gland)

    What food or medicine must I avoid when I take Prochlorperazine ?

    ​Avoid drinking alcohol while taking this medication as it can increase drowsiness side effect 

    Prochlorperazine - Dosage and How to Use

    How should Prochlorperazine be used?

    • ​It is available as tablet and injection formulation 
    • Follow the instructions on the medication label and take this medication as prescribed by your doctor
    • If your symptoms become persistent or worsening, seek help from your medical doctor as soon as possible
    • You may take this medication with or without food. 

    What should I do if I miss a dose?

    ​If you forget to take a dose, take it as soon as you remember. Then take your next dose at the usual time. Do not take two doses to make up for the missed dose. 

    Do not take double the  dose for any  missed dose iIf you are taking  this medication as and when needed. 

    What should I do if I overdose?

    Prochlorperazine - Handling

    How should I handle Prochlorperazine safely?

    Prochlorperazine - Storage

    How should I store Prochlorperazine ?

    ;#Keep away from children;#Keep in a cool, dry place, away from direct sunlight;#

    How should I dispose of Prochlorperazine safely?

    ​Pack this medication into a black trash bag and seal it tightly before throwing it into the rubbish chute or bin. 

    Prochlorperazine - Additional Information

    ​The symptoms of a drug allergy include one or more of the following: 

    • Swollen face/eyes/lips/tongue
    • Difficulty in breathing
    • Itchy skin rashes over your whole body

    Rarely this medication may cause:

    •  High fever, severe muscle stiffness, confusion, irregular blood pressure (signs and symptoms of neuroleptic malignant syndrome)
    • Muscle stiffness and spasms (such as in the face, neck and back), difficulty in speaking or swallowing, twitching or upward rolling of eyes (dystonia)
    • Uncontrollable movements (such as in the face, tongue, jaw or other parts of the body) ({tardive dyskinesia)
    • Fever, sore throat and/or mouth ulcers that do not go away (symptoms of blood dyscrasia)
    • Increased prolactin hormone in the blood (hyperprolactinemia)
      • Changes in menstrual cycle in females (irregular or stopping of menstrual periods) and/or
      • Abnormal breast swelling, soreness or secretion (in both men and women)  

    If you experience any of these symptoms, you should stop your medication and see your healthcare professional immediately

    • Updated on 7/31/2022 12:00:00 AM
    • Article contributed by Sengkang General Hospital Sengkang General Hospital
    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

    Find Your Medicines