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Methotrexate Injection

Drug Class: Commonly Known As: Category:
Antimetabolite Cancer-related

Methotrexate Injection - Side Effects, Precautions, and Contraindications

What side effects can Methotrexate Injection cause?

Early side effects

  • Mild nausea, vomiting or appetite loss may be experienced
    There are medications available, which may prevent or decrease these side effects. If you are given these medications, take them as directed.

Delayed side effects

  • A drop in the blood counts may occur 4 to 10 days after treatment
  • Mouth ulcers may occur
  • Diarrhea may occur
  • Tiredness and drowsiness may occur
  • Increased sensitivity to sunlight may occur. Rashes may occur with excessive exposure to the sun. 
    Avoid prolonged exposure to sunlight. The use of a sunscreen and/or protective clothing may be helpful.

Please seek medical attention if any of the following occurs:

  • Fever of 38°C or higher
  • Unusual bruising or bleeding, such as passing of black tarry stools, dark urine or vomiting of blood
  • Severe sore throat, hoarseness or mouth sores
  • Severe nausea and vomiting that persist for more than 3 days
  • Severe diarrhea (more than 4 times a day)
  • Persistent dry cough or shortness of breath
  • Severe headache, confusion, blurred vision, slurred speech or seizures

Before taking Methotrexate Injection, what precautions must I follow?

What food or medicine must I avoid when I take Methotrexate Injection?

Methotrexate Injection - Dosage and How to Use

How should Methotrexate Injection be used?

What should I do if I miss a dose?

What should I do if I overdose?

Methotrexate Injection - Handling

How should I handle Methotrexate Injection safely?

Methotrexate Injection - Storage

How should I store Methotrexate Injection?

How should I dispose of Methotrexate Injection safely?

Methotrexate Injection - Additional Information

  • Updated on Friday, September 21, 2018
  • Article contributed by Department of Pharmacy National Cancer Centre Singapore

    The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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