Cabozantinib

• ​Nausea, decreased appetite
• Take small, frequent meals throughout the day
• Diarrhea
• Drink plenty of clear fluids to replace those lost (two litres everyday)
• Palms of the hands or soles of the feet may become numb, sore, red or dry
• Moisturize these areas daily
• Avoid wearing tight-fitting shoes
• Feeling tired and lack of energy
• Do not drive or operate machinery when you feel tired
• Mouth sores
• Rinse your mouth after meals using an alcohol-free mouthwash or salt water
• Brush your teeth with a soft toothbrush
• Increased blood pressure
• Monitor your blood pressure regularly and record it down. Inform your doctor if you notice an increasing trend.
  

• Very bad stomach pain
  
• Signs of infection - fever of 38° C and above, chills, cough, sore throat, pain or burning feeling on passing urine
• Unusual bleeding, bruising, black sticky stools or blood in the urine
• Unusual weakness, tiredness or light-headedness
• Signs of blood clot e.g. warmth, pain or redness with swelling on arm or leg
• Chest pain or shortness of breath
• Very bad diarrhea
• Painful blisters and peeling of hands or feet
• Symptoms of a drug allergy including one or more of the following:
  
• Swollen face/eyes/lips/tongue
• Difficulty in breathing
• Itchy skin rashes over your whole body

​Inform your healthcare professional if:

• You are allergic to this medication
• You or your partner becomes pregnant or is planning for pregnancy
• You should use effective birth control during and for four months after stopping treatment
• You are breastfeeding
• Do not breastfeed during and for four months after stopping treatment
• You have any other medical conditions such as heart problems or high blood pressure
• You are taking or intend to take any other medications, including supplements, traditional medications and herbal remedies
• You have any recent or upcoming surgery
• You have any dental problems
• Practice good oral hygiene while you are taking Cabozantinib
• Be sure to let your dentist know you are taking Cabozantinib so that appropriate precautions can be taken

​Avoid taking grapefruit or grapefruit juice when you are taking this medication as it may interact with your medication and increase the risk of side-effects.