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Von Hippel-Lindau Syndrome

Von Hippel-Lindau Syndrome - How to prevent?

Von Hippel-Lindau Syndrome - Causes and Risk Factors

How is VHL inherited?

VHL runs in families and can be passed down. It can affect both males and females.

VHL follows a dominant inheritance pattern. This means that having one faulty copy of the VHL gene can cause the condition.

Everyone has 2 copies of each gene in their body’s cells:

  • 1 copy comes from our father
  • 1 copy comes from our mother
Dominant inheritance pattern - Von Hippel-Lindau Syndrome
  • A parent with a faulty gene(s) has a 50% chance of passing down their faulty gene(s) to their children.
  • A child, sibling or parent of a family member with a faulty gene(s) has a 50% chance of also inheriting the same faulty gene(s).
  • Extended relatives may also inherit the faulty gene(s).

While VHL may run in families, an estimated 20% of individuals with VHL may have acquired a faulty VHL gene at birth (de novo). Therefore, genetic testing may be offered in the absence of relevant family history if an individual’s personal history is suspicious for VHL.

Von Hippel-Lindau Syndrome - Preparing for surgery

Von Hippel-Lindau Syndrome - Post-surgery care

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth