Dr Melissa Hum
Lee Ning Yuan
Lim Wei Kiat
The Laboratory of Molecular Oncology is a translational cancer research laboratory. We collaborate with clinicians, clinician-scientists and scientists from hospitals, universities and research institutions across Singapore. In addition, we have established collaborative projects with industry partners, funded by competitive grants.
Our research focusses on:
Our interest in biomarker discovery has led to the identification of circulating microRNA signatures for breast cancer which can potentially be developed as blood-based assays for the early detection of breast cancer. In addition, our cancer genetic studies have identified novel genetic variations, with some being associated with increased cancer risk.
Among our key research findings, our research group has:
Our group has published in international journals such as
Lancet Oncology, Journal of Clinical Oncology, Cancer Research, Clinical Cancer Research and
Oncogene. Our research work is funded primarily by competitive grants from the National Medical Research Council (NMRC) of Singapore and Industry Alignment Funds (IAF-ICP and IAF-PP), with support from the NCC Research and Cancer Funds.
Figure 1. Strategy used for the development of a biomarker panel for breast cancer (Adapted from Cancers (Basel) (2021) 13(9):2130. doi: 10.3390/cancers13092130. PMID: 33925125)
Selected Publications (* = corresponding author)
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