Dr Wan Ling TAN
Dr Quan Sing NG
Dr Sylvia CHEN
The Laboratory of Clinical Pharmacology, headed by Prof. Balram Chowbay, focuseson translational research projects aimed at improving clinical outcomes through theoptimisation of drug dosages based on pharmacokinetic (PK) and pharmacodynamic(PD) principles. The laboratory also focuses on applying pharmacogenomics tools and knowledge to explain inter-patient variability in drug response and toxicity. This is particularly important in the context of the multi-ethnic Asian population in Singapore because inter-ethnic differences in the polymorphisms of genes that encode drugmetabolising enzymes and transporters may lead to marked variabilities in the PK and PD of anti-cancer drugs.
As a dynamic working unit, our laboratory has developed extensive capabilities overthe years in the development and validation of bio-analytical assays, therapeutic drug monitoring, as well as PK and PD analyses of various anti-cancer agents. We also have considerable experience in the characterisation of variants in the genes encoding drugmetabolising enzymes and transporters and their impact on drug disposition across different ethnic groups.
In addition, our laboratory provides the critical support and expertise necessary toeffectively conduct early-phase clinical trials within the Department of Medical Oncology. Our participation ranges from concept proposal, study protocol design, clinical specimen acquisition, processing, analysis and storage to data analysis and results generation.
We are hopeful that such patient-oriented research will further augment existing treatment strategies to improve survival outcomes and clinical responses for cancer patients.
Figure 1: PHARMACOKINETICS & PHARMACODYNAMICS RELATIONSHIPS
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11 Hospital Drive, Singapore 169610 +65 6436 8000