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Asst Prof Yang Valerie Yang Shiwen

Asst Prof Yang Valerie Yang Shiwen

BSc (First Class Honours), MBBChir (Cantab), PhD (Cantab), MRCP (UK), FAMS (Medical Oncology)

Associate Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology

Sub-specialties: Sarcoma, Lymphoma, Skin & Melanoma

Conditions Treated by this Doctor:
Lymphoma, Melanoma, Sarcoma, Skin Cancer.

Clinical Appointments

  • Associate Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Associate Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Profile

Dr Valerie Yang is an Associate Consultant, Division of Medical Oncology at the National Cancer Centre Singapore. She is jointly appointed as a Research Clinician & Group Leader at the Institute of Molecular and Cell Biology, A*STAR. Her interests include Sarcomas, Lymphomas and Melanomas.

She received the National Science Scholarship from the Agency for Science, Technology and Research (A*STAR) to read Medicine and a PhD. She graduated from the Royal Free and University College Medical School with Distinctions in Preclinical Medicine and First Class Honours for a Bachelor of Science (BSc) in Molecular Medicine.

She was conferred the Cluff Memorial Prize and the Goldberg-Schachmann and Freda Becker Memorial Award, and joined the A*STAR Chairman’s Honours List. Dr. Yang then read Clinical Medicine at the University of Cambridge, where she was accepted into the prestigious MB/PhD Programme. Her PhD in Oncology was supervised by Dr. Michael Gonzalez and Professor Ronald Laskey, where she studied DNA replication, cell cycle regulation and embryonic stem cell pluripotency. Upon return to Singapore, Dr. Yang underwent Internal Medicine residency training and was accepted to the Membership of the Royal College of Physicians (MRCP), UK, before receiving specialty training in Medical Oncology at the NCCS. She was also conferred the Nurturing Clinician Scientists Scheme Award (NCSS) by SingHealth for Sarcoma research while concurrently undergoing specialty training. She is now accredited as a Specialist in Medical Oncology and a Fellow of the Academy of Medicine of Singapore.

Education

  • Fellow of the Academy of Medicine, Singapore (Medical Oncology), 2019
  • Specialist Accreditation in Medical Oncology, Ministry of Health Singapore, 2019
  • MRCP, Royal College of Physicians (UK), 2014
  • PhD, University of Cambridge, 2010
  • MBBChir, University of Cambridge, 2010
  • Bachelor of Science with First Class Honours, University College London, 2003

Professional Appointments and Committee Memberships

  • Assistant Professor, Oncology Academic Clinical Program, Duke-NUS Medical School, 2021 - Present
  • Associate Consultant, Division of Medical Oncology, National Cancer Centre 2019 – Present
  • Associate Consultant, SingHealth Duke-NUS Blood Cancer Centre, 2019 – Present
  • Research Clinician & Group Leader, Institute of Molecular and Cell Biology, A*STAR, 2019 - Present
  • Adjunct Instructor, Oncology Academic Clinical Program, Duke-NUS Medical School, 2019 – 2021
  • American Association for Cancer Research, 2015 - Present
  • Singapore Society of Oncology (SSO), 2014 – Present
  • American Society of Clinical Oncology (ASCO), 2014 – Present
  • European Society of Medical Oncology (ESMO), 2014 – Present

Awards

  • National Medical Research Council (NMRC) Transition Award, 2021
  • Nurturing Clinician Scientists Scheme Award, SingHealth, 2016
  • Academic Development Programme, National University Hospital, 2012
  • First Prize for Oral Presentation, Graduate Research Symposium, Cambridge University, 2009
  • Goldberg-Schachmann and Freda Becker Memorial award, University of London, 2003
  • Cluff Memorial Prize, Royal Free and University College Medical School, 2003
  • Distinction in Medical Sciences, Royal Free and University College Medical School, 2003
  • Chairman’s Honours List, A*STAR Graduate Academy, 2003
  • National Science Scholarship (MBBS-PhD), A*STAR, 2001

Research Interests

Drug screening, Epigenetic regulation, Biomarkers, Patient-derived models, Immunotherapy, Translational Artificial Intelligence and Machine Learning, Single-cell and digital spatial profiling technologies, Personalised medicine, Sarcoma, Lymphoma, Melanoma, Skin and rare cancers

Publications

  1. Yang VS et al., 2011, ‘Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog’, Current Biology 21 (8), 692-699
  2. Yang VS et al., 2012, ‘Distinct activities of the anaphase-promoting complex/cyclosome (APC/C) in mouse embryonic cells’, Cell Cycle 11 (5), 846-855
  3. Yang VS et al., 2020, ‘Clinicopathologic Features and Whole Genome Sequencing of a Primary Osteosarcoma of the Uterus’, Journal of Immunotherapy and Precision Oncology 3 (2), 90-95
  4. Chiang J, Yang VS et al., 2020, ‘Minimizing transmission of COVID-19 while delivering optimal cancer care in a National Cancer Centre’, Journal of Cancer Policy 25, 100241
  5. Yap DRY, Tan GF, Chang EWY, Yang VS et al., 2020, ‘Clinical Features of Plasmablastic Lymphoma: Case Series From an Asian Tertiary Cancer Center and Literature Review’, Journal of Haematology 9 (3), 71
  6. Tan L, Hong J, Goh WL, Chang EWY; Yang VS et al., 2020, ‘Clinical features and survival outcomes of ocular melanoma in a multi-ethnic Asian cohort’ Sci Rep 10, 16367 (2020)
  7. Lo YT, Ang YLS, Yang VS et al., 2020, ‘Motor deficits at presentation and predictors of overall survival in central nervous system lymphomas’, J Neurooncol. 2021 Jan 4. doi: 10.1007/s11060-020-03665-8. PMID: 33398535.
  8. Tan CJ, Kumar R, Koomanan N, Loo WS, Farid M, Tao M, Somasundaram N, Poon E, Chan JY, Yang VS et al., 2021, ‘Clinical and economic evaluation of a surveillance protocol to manage hepatitis B virus (HBV) reactivation among lymphoma patients with resolved HBV infection receiving rituximab’, Pharmacotherapy, 41: 332-341.
  9. Tham CSW, Tan YH, Chew KMYC, Khoo CY, Lee L, Lim ST, Yang VS. 2021, ‘An Unusual Presentation of Lymphoma’, Current Problems in Cancer.
  10. Yang X, Khoo LP, Chang EWY, Yang VS et al., 2021, ‘Treatment patterns and outcomes of older patients with mantle cell lymphoma in an Asian population’, BMC Cancer 21, 566 (2021).

Research Trials