Clin Asst Prof Tiffany Hennedige

MBBS (Hon-1), FRCR (UK), MMed (Diag Radiol), MCI (S’pore)

Head & Senior Consultant

National Cancer Centre Singapore National Cancer Centre Singapore

Specialty: Oncologic Imaging

Clinical Interests

Breast & Body Imaging (Colorectal, Gynae-Oncology, Hepato-Pancreato-Biliary, Uro-Oncology), Peritoneal-based Malignancies, Sarcoma

Clinical Appointments

Head & Senior Consultant

Division of Oncologic Imaging

Academic Appointments

Clinical Asst Professor

About

Dr Tiffany Hennedige graduated with First Class Honours from Monash University, Australia, in 2005. She completed her postgraduate training in Diagnostic Radiology in Singapore and obtained both the FRCR and MMed (Diagnostic Radiology) in 2011. Following her basic and advanced radiology training, she joined the National Cancer Centre Singapore (NCCS) in 2014 as an Associate Consultant.

Dr Hennedige has a strong academic and research background, with a primary focus in body oncology imaging. She has authored over 30 peer-reviewed publications and has presented at numerous local and international conferences, including the Radiological Society of North America (RSNA), Asian Oceanian Congress of Radiology (AOCR), International Cancer Imaging Society (ICIS) and Singapore Radiological Society (SRS).

In 2017, she obtained a Master of Clinical Investigation from the National University of Singapore (NUS). She has been awarded over S$200,000 in research grants in support of her work. Dr Hennedige is a Fellow of the Royal College of Radiologists and a member of several professional bodies including the International Cancer Imaging Society, Singapore Radiological Society, Singapore Medical Association, Radiological Society of North America, and the Golden Key International Honour Society.

Education and Training

  • 2017, Masters of Clinical Investigation MCI (National University of Singapore)
  • 2011, Masters of Medicine MMed (Diagnostic Radiology, National University of Singapore)
  • 2011, Fellow of the Royal College of Radiologists FRCR (London, UK)
  • 2005, Bachelor of Medicine and Bachelor of Surgery MBBS (Monash University, Australia)

Professional Appointments and Committee Memberships

  • 2019, Member, International Cancer Imaging Society (ICIS)
  • 2015, Deputy Director, Functional & Molecular Imaging Research, Radiological Sciences Academic Clinical Programme
  • 2011, Member, Radiological Society of North America (RSNA)
  • 2011, Fellow, Royal College of Radiologists (RCR)
  • 2009, Member, Singapore Radiological Society (SRS)
  • 2007, Member, Singapore Medical Association (SMA)
  • 2002, Member, Golden Key International Honour Society

Awards

  • 2021, Sponsorship for Leading Business Transformation in Asia by INSEAD
  • 2018, Silver Singapore Health Quality Service Award
  • 2016, Khoo Pilot Award (KPA)
  • 2015, Awarded MOH Healthcare Research Scholarship
  • 2009, Young Investigator Award at the 18th Annual Scientific Meeting of Singapore Radiological Society

Research Trials

  • 2017, Nuclear Imaging of T cell Infiltration in the Murine MCA Sarcoma Model using mLAMA4 MHC Tetramer, Onco ACP Cancer Collaborative Grant
  • 2016, Nuclear Imaging of T cell Infiltration in the Murine MCA Sarcoma Model using mLAMA4 MHC Tetramer, Khoo Pilot Award (KPA)
  • 2016, Use of intravoxel incoherent motion for the detection of metastatic regional nodes in pelvic car-cinomas, Masters of Clinical Investigation , NMRC Research grants
  • 2015, Use of Dynamic PET and Double- Input Compartmental Modelling to Determine Concentra-tion of Parent Drug in Tumours, SingHealth Duke- NUS Radiological Sciences Academic Clinical Program Research Support Grant

Publications

  • Tai D, Loke K, Gogna A, Kaya NA, Tan SH, Hennedige T, Ng D, Irani F, Lee J, Lim JQ, Too CW, Ng MCH, Tham CK, Lam J, Koo SL, Chong HS, Goh GB, Huang HL, Venkatanarasimha N, Lo R, Chow PKH, Goh BKP, Chung A, Toh HC, Thng CH, Lim TKH, Yeong J, Zhai W, Chan CY, Choo SP. Radioembolisation with Y90-resin microspheres followed by nivolumab for advanced hepatocellular carcinoma (CA 209-678): a single arm, single centre, phase 2 trial. Lancet Gastroenterol Hepatol. 2021 Dec;6(12):1025-1035.
  • Sommat K, Lin JYX, Chew MML, Loh CS, Liew JSK, Foo YW, Kwek JW, Hennedige T, Goh JPS, Tan TK. Non-anesthetist-administered moderate sedation with midazolam and fentanyl for outpatient MRI-aided hybrid intracavitary and interstitial brachytherapy in cervix cancer: a single-institution experience. J Contemp Brachytherapy. 2021 Jun;13(3):286-293.
  • Akram F, Koh PE, Wang F, Zhou S, Tan SH, Paknezhad M, Park S, Hennedige T, Thng CH, Lee HK, Sommat K. Exploring MRI based radiomics analysis of intratumoral spatial heterogeneity in locally advanced nasopharyngeal carcinoma treated with intensity modulated radiotherapy. PLoS One. 2020 Oct 5;15(10):e0240043.
  • Wong DJ, Lee J, Choo SP, Thng CH, Hennedige T. Hyperprogressive disease in hepatocellular carcinoma with immune checkpoint inhibitor use: a case series. Immunotherapy. 2019 Feb;11(3):167-175.
  • Srinivasan N, Teo JY, Chin YK, Hennedige T, Tan DM, Low AS, Thng CH, Goh BKP. Systematic review of the clinical utility and validity of the Sendai and Fukuoka Consensus Guidelines for the management of intraductal papillary mucinous neoplasms of the Pancreas. HPB (Oxford). 2018 Feb 24.
  • Chew MH, Yeh YT, Toh EL, Sumarli SA, Chew GK, Lee LS, Tan MH, Hennedige TP, Ng SY, Lee SK, Chong TT, Abdullah HR, Goh TLH, Rasheed MZ, Tan KC, Tang CL. Critical evaluation of contemporary management in a new Pelvic Exenteration Unit: The first 25 consecutive cases. World J Gastrointest Oncol. 2017 May 15; 9(5): 218-27.
  • Hennedige T, Ng DCE, Tao M, Quek RHH, Lim ST, Kwek JW. Evaluation of whole body diffusion-weighted imaging in the staging and treatment response of lymphoma compared with FDG PET/CT as a reference standard. Radiol Open J. 2017; 2(1):17-25.
  • Hennedige TP, Wang G, Leung FP, Alsaif HS, Teo LL, Lim SG, Wee A, Venkatesh SK. Magnetic Resonance Elastography and Diffusion Weighted Imaging in the Evaluation of Hepatic Fibrosis in Chronic Hepatitis B. Gut Liver. 2016 Dec 16.
  • Hennedige TP, Hallinan JT, Leung FP, Teo LL, Iyer S, Wang G, Chang S, Madhavan KK, Wee A, Venkatesh SK. Comparison of magnetic resonance elastography and diffusion-weighted imaging for differentiating benign and malignant liver lesions. Eur Radiol. 2016 Feb;26(2):398-406.
  • Hennedige T, Venkatesh SK. Advances in computed tomography and magnetic resonance imaging of hepatocellular carcinoma. World J Gastroenterol. 2016 Jan 7;22(1):205-20.
  • Hennedige T, Yang ZJ, Ong CK, Venkatesh SK. Utility of non-contrast-enhanced CT for improved detection of arterial phase hyperenhancement in hepatocellular carcinoma. Abdom Imaging. 2014 Dec;39(6): 1247-54.
  • Hennedige T, Neo WT, Venkatesh SK. Imaging of malignancies of the biliary tree- An update. Cancer Imaging 2014; 14:14.
  • Hennedige TP, Venkatesh SK. Imaging of Hepatocellular carcinoma: diagnosis, staging and treatment monitoring. Cancer Imaging 2013 Feb:12(3):530-547.
  • Huellner MW, Hennedige TP, Winterhalder R, Zander T, Venkatesh SK, Yong WP, Soo RA, Seifert B, Treumann TC, Strobel K, Veit-Haibach P. Prognostic value of different CT measurements in early therapy response evaluation in patients with metastatic colorectal cancer. Cancer Imaging. 2012 May 21;12:212-24.
  • Hennedige T, Teo L, Ang B, Cheong WK, Venkatesh SK. Accuracy of preoperative CT for local staging in colorectal carcinomas. Singapore Med J. 2010 Jun;51(6):475-80.