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Assoc Prof Tan Bee Huat Iain

Assoc Prof Tan Bee Huat Iain


Senior Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology, Medical Oncology

Clinical Interest: Colorectal, Upper Gastrointestinal, Hepato-Pancreato-Biliary, Peritoneal-based Malignancies

Conditions Treated by this Doctor:
Colorectal Cancer, Hepato-Pancreato-Biliary Cancers, Oesophagus Cancer, Peritoneal based Malignancies, Stomach Cancer.

Clinical Appointments

  • Senior Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Senior Clinician Scientist
  • Associate Professor


Dr. Iain Tan is a Senior Consultant Medical Oncologist, leading the colorectal cancer service in the GI Oncology Team at the Department of Medical Oncology, National Cancer Centre Singapore. He co-chairs Singhealth’s multidisciplinary colorectal cancer tumor board. Nationally, he chairs the Medical Oncology Exit Exam committee for specialist accreditation & is a member of MOH’s research training review panel & NMRC’s grant review panel. At NCCS, he is also the clinical chair for NCCS’s luminal GI cancer Comprehensive Research Program. Concurrently, he is a clinician scientist at Genome Institute of Singapore and an assistant professor at Duke-NUS. His research focuses –on metastases and drug resistance and immune-oncology in gastrointestinal cancers, with a special interest in non-invasive diagnostics & innovative early phase clinical trials. He has published widely, with many first or corresponding authorpublications in leading journals including Journal of Clinical Oncology, Nature Medicine, Nature Genetics, Science Translational Medicine and Lancet Oncology. For his research, he has received the ASCO Young Investigator Award (2010) and ASCO Merit Award (2011) and Singhealth Distinguished Young Researcher Award. For his clinical service & research, he received the Singapore Youth Award in 2014, the country’s highest award for youths.


  • PhD - National University of Singapore (NUS)/NGS 
  • Specialist in Medical Oncology (FAMS) - Singapore Medical Council 
  • MRCP (UK) - Royal College of Physicians (UK) 
  • MBBS - National University of Singapore

Professional Appointments and Committee Memberships

  • Chairman, Ministry of Health JCST Exit Exam Committee (Medical Oncology) 
  • Member, Research Committee Research Training Review Panel, Ministry of Health 
  • Member, Board of the Chapter of Clinician Scientists, Singapore -- Academy of Medicine, Singapore
  • Member, SingHealth's Patent Review Committee 
  • Member, SingHealth centralised institutional review board
  • Member, European Society of Medical Oncology 
  • Member, American Association of Clinical Research 
  • Member, American Society of Clinical Oncology 
  • Member, Singapore Society of Oncology


  • SingHealth Publish! Award (Outstanding), 2016 
  • NMRC Clinician Scientist Award, 2015 
  • Singapore Youth Award, 2014
  • SingHealth Excellence Award: Distinguished Young Researcher Award, 2013 
  • SingHealth Publish! Award (Outstanding), 2012 
  • SingHealth Quality Award (Silver), 2011
  • ASCO Merit Award (American Society of Clinical Oncology), 2011
  • AACR-BMS Scholar in Training Award, 2010 
  • American Society of Clinical Oncology Young Investigator Award, 2010 
  • NRF-MOH Healthcare Research Scholarship, 2010

Research Interests

  • Colorectal Cancer
  • Genomics & immune-oncology
  • Non-invasive diagnostics and early detection of recurrent cancer


  • Huipeng Li#, Elise T. Courtois#, Debarka Sengupta, Yuliana Tan, Kok Hao Chen, Say Li Kong, Clarinda Chua, Yongli Hu, Lawrence Wee, Lim Kiat Hon, Tan Wah Siew, Mark Wong, Paul Jongjoon Choi, Lawrence Wee, Axel M. Hillmer, Iain Beehuat Tan*, Paul Robson*, Shyam Prabhakar* (co-corresponding author) Reference Component Analysis of Single Cell Transcriptomes Reveals Cellular Heterogeneity in Human Colorectal Tumors. Nature Genetics 2017 (in press) 
  • Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB. Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer. Mol Oncol. 2017 Feb;11(2):124-139. 
  • Ng SB, Chua C, Ng M, Gan A, Poon PS, Teo M, Fu C, Leow WQ, Lim KH, Chung A, Koo SL, Choo SP, Ho D, Rozen S, Tan P, Wong M, Burkholder WF, Tan IB. Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery. Sci Rep. 2017 Jan 19;7:40737. 
  • Simoni Y, Fehlings M, Kløverpris HN, McGovern N, Koo SL, Loh CY, Lim S, Kurioka A, Fergusson JR, Tang CL, Kam MH, Dennis K, Lim TK, Fui AC, Hoong CW, Chan JK, Curotto de Lafaille M, Narayanan S, Baig S, Shabeer M, Toh SE, Tan HK, Anicete R, Tan EH, Takano A, Klenerman P, Leslie A, Tan DS, Tan IB, Ginhoux F, Newell EW. Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency. Immunity. 2017 Jan 17;46(1):148-161. 
  • Fukawa T, Chua BY, Chua JM, Tan EJ, Huang D, Qian C, Ong P, Li ZM, Chen SW, Mak SY, Elsa Mohan S, Wang RR, Lim WJ, Kanayama H, Lai JH, Chua C, Ong HS, Tan KK, Ho YS, Tan IB*, The BT*, Ng SC* Excessive fatty acid oxidation induces muscle atrophy in cancer cachexia Nature Medicine 2016 online 2 May 2016 2016 Jun;22(6):666-71. (IF 2730.3) *Co-corresponding author 
  • Tan IB, Malik S, Ramnarayanan K, McPherson JR , Ho DL, Suzuki Y, Ng SB, Su Y, Lim KH, Koh K, Chew MH, Chan CY, Ten R, Goh BKP, Chung AYF, Tan J, Chan CX, Tay ST, Lezhava A, Nagarajan N, Hillmer AM, Tang CL, Chua C, Teh BT, Rozen S, Tan P. High-depth sequencing of over 750 genes supports linear progression of primary tumors and metastases in most patients with liver-limited metastatic colorectal cancer. Genome Biology 2015 Feb 12;16:32 
  • Lei Z, Tan IB, Das K, Deng N, Zouridis H, Pattison S, Chua C, Feng Z, Guan YK, Ooi CH, Ivanova T, Zhang S, Lee M, Wu J, Ngo A, Manesh S, Tan E, Teh BT, So JB, Goh LK, Boussioutas A, Lim TK, Flotow H, Tan P, Rozen SG. Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil. Gastroenterology. 2013 Sep;145(3):554-65. 
  • Ku G*, Tan IB*, Yau T, Boku N, Laohavinij S, Cheng AL, Kang YK, de Lima Lopes G Jr (2012) Management of colon cancer: resource-stratified guidelines 2012 Lancet Oncol 13(11):e470-81 (co-first) 
  • Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, Tan SH, Wu J, Lee MH, Ooi CH, Rha SY, Wong WK, Boussioutas A, Yeoh KG, So J, Yong WP, Tsuburaya A, Grabsch H, Toh HC, Rozen S, Cheong JH, Noh SH, Wan WK, Ajani JA, Lee JS, Tellez MS, Tan P. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy. Gastroenterology. 2011 Aug;141(2):476-85, 485.e1-11. 
  • Tan IB, Cutcutach I, Zhi Jiang Zang, Iqbal J, Yap SF, Hwang W, Lim WT, Rozen S, Tan EH, Tan P. Fanconi's Anemia in Adulthood: Chemoradiation-Induced Bone Marrow Failure and a Novel FANCA Mutation Identified by Targeted Deep Sequencing. J Clin Oncol April 2011

Research Trials

  • A Phase III Study of oral BBI-608 +/- 5-Fluorouracil, Leucovorin, Irinotecan (FOLFIRI) in Adult Patients with Previously Treated Metastatic Colorectal Cancer (Site Principal Investigator) 
  • Customizable circulating tumor nucleic acid assays to monitor disease burden, detect known drug resistance mutations and identify novel drug resistance mutations in patients with metastatic gastrointestinal cancers (NMRC CSA)Patient-primary tumor specific circulating tumor Nucleic acids (pps-ctNAs) as personalized surveillance biomarkers for early detection of recurrent colorectal cancer (NMRC IRG)
  • Identifying genetic dependencies and therapeutic vulnerabilities of metastasis in patient-derived colorectal cancer models (NMRC IRG) 
  • Development of a platform to bridge genomic information with phenotypic information for healthcare and healthcare research (NMRC IAF Cat 1)