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Prof London Ooi

Prof Ooi Peng Jin

MBBS, FRCSEd(Gen Surg) (RCS, UK), FRCS (Gen Surg) (RCPS,Glasg), FAMS (Gen Surg)

Senior Consultant

Singapore General Hospital

Specialty: Surgery & Surgical Oncology, Hepato-pancreato-biliary and Transplant Surgery

Clinical Interest: Hepatobiliary and Pancreatic Surgery

Conditions Treated by this Doctor:
Gallstones, Hepato-Pancreato-Biliary Cancers, Liver Cancer, Liver Tumours, Pancreatic Cancer, Pancreatic Endocrine Tumours, Pancreatic Tumours.

Clinical Appointments

  • Senior Consultant Hepato-pancreato-biliary and Transplant Surgery Singapore General HospitalSingapore General Hospital
  • Visiting Consultant Department of General Surgery Sengkang General HospitalSengkang General Hospital
  • Senior Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore


​Prof Ooi is a senior surgical oncologist with specialisation in hepatobiliary and pancreatic (HPB) cancers. He started as a general surgeon with FRCSEd and FRCSG and exit certification in General Surgery before receiving advanced training in HPB surgery and liver transplantation as Senior Fellow in Australia. He was instrumental in establishing the combined HPB service at SGH and NCCS which now has become the Department of Hepato-pancreato-biliary and Transplant Surgery. He has a Doctorate in Medicine based on his work on liver cancer (HCC) and is involved extensively in various aspects of liver cancer research and clinical trials. He has trained many HPB surgeons in the region. He was also previously Chair of Surgery SGH, Deputy Director National Cancer Centre, inaugural Chair of Surgery ACP at SingHealth and founding Director SingHealth Transplant.


  • MBBS
  • FCSHK Hon
  • FRCSEd
  • FRCS(Glasg)
  • MD
  • Professor

Professional Appointments and Committee Memberships

  • Professor, SingHealth Duke-NUS Surgery Academic Clinical Programme, Duke-NUS Medical School
  • Chairman, TASC, MOH
  • Chief Examiner, General Surgery, MOH
  • Member, RAC, General Surgery, MOH


  • ​PB Desai Oration Gold Medal Lecturer at the 25th Anniversary of the Indian Association of Surgical Oncology, 2007
  • 3rd Yahya Cohen Gold Medal Lecturer of the Academy of Medicine Singapore, 1998
  • Who's Who in Medicine & Healthcare, 2000 - 2009
  • Overseas International Fellow Travelling Scholarship Lecture of Japan Surgical Society, 1994
  • Numerous Research Grant Awards and Service Quality Awards

Research Interests


  • Identification and validation of a novel gene signature associated with the recurrence of human hepatocellular carcinoma.  Wang SM, Ooi PJLL, Hui KM. AACR J Clin Cancer Res 13(21):6275-83, 200.
  • Cloning and identification of HDMCP: a novel liver-specific uncoupling protein that is downregulated in human hepatocellular carcinoma.  Tan MG, Ooi PJLL, Aw SE, Hui KM. J Biol Chem 279;45235-44, 2004.
  • Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers.  Lee CG, Ren J, Cheong IS, Ban KH, Ooi PJLL, Yong Tan S, Kan A, Nuchprayoon I, Jin R, Lee KH, Choti M, Lee LA. Oncogene 22(17):2592-603, 2003.
  • A possible role for insulin-like growth factor-binding protein 3 in human hepatocellular carcinoma.  Huynh H, Chow PKH, Ooi PJLL, Soo KC. Cell Growth Differ 13:115-22, 2002.
  • The role of "myofibroblast-like" cells in hepatocellular carcinoma.  Ooi PJLL. 3rd Yahya Cohen Lecture, Ann Acad Med Singapore 28:342-6, 1999.
  • Outcome of distal pancreatectomy for pancreatic adenocarcinoma.  Goh BK, Tan YM, Cheow PC, Chung YF, Chow KH, Wong WK, Ooi PJLL. Dig Surg 25:32-8, 2008.
  • Pancreatic cyst: a proposed management algorithm based on current evidence.  Goh BK, Tan YM, Chung YF, Chow KH, Cheow PC, Thng CH, Mesenas S, Wong WK, Ooi PJLL. Am J Surg 193:749-55, 2007.
  • Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations.  Jada SR, Shu XC, Yan LY, Xiang XQ, Suman L, Zhuo SF, Ooi PJLL, Chowbray B. Eur J Clin Pharmacol 63:555-63, 2007.
  • Signatures of recent positive selection at the ATP-binding cassette drug transporter superfamily gene loci.  Wang Z, Wang J, Tantoso E, Wang B, Tai AY, Ooi PJLL, Chong SS, Lee CG. Hum Mol Genet 16:1367-80, 2007.
  • A study into the risk of exacerbation of chronic hepatitis B after liver resection for hepatocellular carcinoma.  Thia TJ, Lui HF, Ooi PJLL, Chung YF, Chow PK, Cheow PC, Tan YM, Chow WC. Gastrointest Surg 11:612-8, 2007.
  • Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm.  Goh BK, Ooi PJLL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, Chung YF, Wong WK. Pancreatology 6:520-6, 2006.
  • Image-guided radiofrequency ablation of liver malignancies: experience at Singapore General Hospital.  Low SC, Lo RH, Lau TN, Ooi PJLL, Ho CK, Tan BS, Chung AY, Koo WH, Chow PK. Ann Acad Med Singapore 35:851-7, 2006.
  • Cystic lesions of the pancreas: an appraisal of an aggressive resectional policy adopted at a single institution during 15 years.  Goh BK, Tan YM, Cheow PC, Chung AY, Chow PK, Wong WK, Ooi PJLL. Am J Surg 192:148-54, 2006.
  • Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients.  Wang BS, Ren JW, Ooi PJLL, Chong SM, Lee CGL. Oncogene 1-10, 2005.
  • Systemic administration of naked DNA with targeting specificity to mammalian kidneys.  Wu X, Gao H, Pasupathy S, Tan PH, Ooi PJLL, Hui KM. Gene Therapy 12:477-86, 2005.
  • Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: implications for adjuvant use of kinase-inhibitory drugs.  Lim YP, Epstein R, Wong CY, Ooi PJLL. Clin Cancer Res 10:3980-7, 2004.
  • Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore.  Lee ASG, Ho GH, Oh PC, Balram C, Ooi PJLL, Lim TH, Wong CY, Hong GS. Human Mutation. 2003, #633.
  • Evidence that myofibroblast-like cells are the cellular source of capsular collagen in hepatocellular carcinoma.  Ooi PJLL, Crawford DHG, Gotley DC, Clouston AC, Strong RW, Gobe GC, Halliday JW, Bridle KR, Ramm GA. J Hepatol 26:798-807, 1997.
  • Human liver transplant perfusate: an abundant source of donor liver associated leucocytes.  Jonsson JR, Hogan PG, Balderson GA, Ooi PJLL, Lynch SV, Stong RW, Powell EE. Hepatology 26:1111-4, 1997.
  • Current status of surgery in the management of hepatocellular carcinoma.  Tan YM, Ooi PJLL. Cancer Rev: Asia-Pacific 1:211-6, 2003.

Research Trials