Profile
Dr Dawn Chong is a Senior Consultant Medical Oncologist at the Division of Medical Oncology, National Cancer Centre Singapore (NCCS) and specializes in gastrointestinal cancers.
Dr Chong received the Singhealth Health Manpower Development Plan (HMDP) Fellowship award and completed a fellowship in clinical and translational cancer epidemiology at the Massachusetts General Hospital. She also received the National Medical Research Council (NMRC) Research Training Fellowship and obtained a degree in Master of Public Health at the Harvard T.H. Chan School of Public Health.
Dr Chong's research focuses on cancer epidemiology, with the aim of critical analyses of epidemiologic exposures with clinical and genetic information to elucidate novel biomarkers that can be used to risk stratify patients and guide treatment decisions. She was awarded the NMRC Transition Award for her research on metabolites in colorectal cancer. She has published in many high impact journals including JAMA Oncology and Lancet Oncology.
Dr Chong is an Assistant Professor of the Duke-NUS Graduate Medical School and a clinical lecturer of the Yong Loo Lin Medical School. She has been actively involved in the training of undergraduates and young clinicians.
Education
- MPH, Harvard T.H. Chan School of Public Health
- Specialist in Medical Oncology, Ministry of Health Specialist Accreditation Board
- MRCP, Royal College of Physicians, Glasgow (UK)
- M.B.B.S, National University of Singapore
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Professional Appointments and Committee Memberships
- Honorary Treasurer, Singapore Society of Oncology (SSO)
- Member, Singapore Medical Association (SMA)
- Member, Academic Medicine Education Institute (AMEI)
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Awards
- National Medical Research Council Transition Award 2018
- National Medical Research Council New Investigator Grant 2015
- National Medical Research Council Research Training Fellowship Award 2015
- Singhealth Health Manpower Development Plan Fellowship Award 2013
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Research Interests
- Cancer Epidemiology
- Colorectal Cancer
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Publications
- Seow-En I, Chok AY, Matchar DB, Yoon S, Chong DQ, Tan EK. Long-term quality of life, sexual health and gastrointestinal function following colorectal cancer resection in an Asian cohort. Colorectal Dis. 2021 Sep;23(9):2348-2360. doi: 10.1111/codi.15768.
- Yang GM, Zhou S, Xu Z, Goh SS, Zhu X, Chong DQ, Tan DS, Kanesvaran R, Yee AC, Neo PS, Cheung YB. Comparing the effect of a consult model versus an integrated palliative care and medical oncology co-rounding model on health care utilization in an acute hospital - an open-label stepped-wedge cluster-randomized trial. Palliat Med. 2021 Sep;35(8):1578-1589. doi: 10.1177/02692163211022957.
- Simon TG, Kim MN, Luo X, Liu X, Yang W, Ma Y, Chong DQ, Fuchs CS, Stampfer M, Giovannucci EL, Chan AT, Zhang X. Adiposity, Adulthood Weight Change, and Risk of Incident Hepatocellular Carcinoma. Cancer Prev Res (Phila). 2021 Oct;14(10):945-954. doi: 10.1158/1940-6207.CAPR-20-0549. Epub 2021 Jul 15.
- Zhu G, Guo YA, Ho D, Poon P, Poh ZW, Wong PM, Gan A, Chang MM, Kleftogiannis D, Lau YT, Tay B, Lim WJ, Chua C, Tan TJ, Koo SL, Chong DQ, Yap YS, Tan I, Ng S, Skanderup AJ. Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden. Nat Commun. 2021 Apr 13;12(1):2229. doi: 10.1038/s41467-021-22463-y.
- Yang W, Sui J, Ma Y, Simon TG, Chong D, Meyerhardt JA, Willett WC, Giovannucci EL, Chan AT, Zhang X. A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women. Int J Cancer. 2020 Mar 1;146(5):1241-1249. doi: 10.1002/ijc.32423.
- Petrick JL, McMenamin ÚC, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Simon TG, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Robien K, Purdue MP, Poynter JN, Palmer JR, Lu Y, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Graubard BI, Giovannucci E, Gaziano JM, Gapstur SM, Freedman ND, Florio AA, Chong DQ, Chen Y, Chan AT, Buring JE, Freeman LEB, Bea JW, Cardwell CR, Campbell PT, McGlynn KA. Exogenous hormone use, reproductive factors and risk of intrahepatic cholangiocarcinoma among women: results from cohort studies in the Liver Cancer Pooling Project and the UK Biobank. Br J Cancer. 2020 Jul;123(2):316-324. doi: 10.1038/s41416-020-0835-5.
- Simon TG, Kim MN, Luo X, Yang W, Ma Y, Chong DQ, Fuchs CS, Meyerhardt JA, Corey KE, Chung RT, Stampfer M, Zhang X, Giovannucci EL, Chan AT. Physical Activity Compared to Adiposity and Risk of Liver-Related Mortality: Results from Two Prospective, Nationwide Cohorts. J Hepatol. 2020 Jun;72(6):1062-1069. doi: 10.1016/j.jhep.2019.12.022.
- Petrick JL, Florio AA, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Van Den Eeden SK, Stanczyk FZ, Simon TG, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Purdue MP, Palmer JR, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Guillemette C, Graubard BI, Giovannucci E, Gaziano JM, Gapster SM, Freedman ND, Engel LS, Chong DQ, Chen Y, Chan AT, Caron P, Buring JE, Bradwin G, Beane Freeman LE, Campbell PT, McGlynn KA. Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Liver Cancer Among Postmenopausal Women. Hepatology. 2020 Aug;72(2):535-547. doi: 10.1002/hep.31057.
- Florio AA, Campbell PT, Zhang X, Zeleniuch-Jacquotte A, Wactawski-Wende J, Smith-Warner SA, Sinha R, Simon TG, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Robien K, Renehan AG, Purdue MP, Poynter JN, Palmer JR, Newton CC, Lu Y, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Kirsh VA, Hofmann JN, Graubard BI, Giovannucci E, Gaziano JM, Gapstur SM, Freedman ND, Demuth J, Chong DQ, Chan AT, Buring JE, Bradshaw PT, Beane Freeman LE, McGlynn KA, Petrick JL. Abdominal and gluteofemoral size and risk of liver cancer: The liver cancer pooling project. Int J Cancer. 2020 Aug 1;147(3):675-685. doi: 10.1002/ijc.32760.
- Lam JYC, Choo SP, Tai DW, Tan IBH, Tham CK, Koo WH, Ong SYK, Ang SF, Chua CWL, Chong DQ, Teo PTH, Lee CJZ, Ee SCE, Ng MCH. What is the value of third-line chemotherapy in advanced gastroesophageal cancer? A 5-year retrospective analysis at a single center.
Asia Pac J Clin Oncol. 2020 Feb;16(1):23-27. doi: 10.1111/ajco.13285. - Yang W, Sui J, Ma Y, Simon TG, Chong D, Meyerhardt JA, Willett WC, Giovannucci EL, Chan AT, Zhang X. A prospective study of dairy product intake and the risk of hepatocellular carcinoma in U.S. men and women. Int J Cancer. 2020 Mar 1;146(5):1241-1249. doi: 10.1002/ijc.32423.
- Yang W, Ma Y, Liu Y, Smith-Warner SA, Simon TG, Chong DQ, Qi Q, Meyerhardt JA, Giovannucci EL, Chan AT, Zhang X. Association of Intake of Whole Grains and Dietary Fiber With Risk of Hepatocellular Carcinoma in US Adults. JAMA Oncol. 2019 Jun 1;5(6):879-886. doi: 10.1001/jamaoncol.2018.7159.
- Simon TG, Ma Y, Ludvigsson JF, Chong DQ, Giovannucci EL, Fuchs CS, Meyerhardt JA, Corey KE, Chung RT, Zhang X, Chan AT. Association Between Aspirin Use and Risk of Hepatocellular Carcinoma. JAMA Oncol. 2018 Dec 1;4(12):1683-1690. doi: 10.1001/jamaoncol.2018.4154. Erratum in: JAMA Oncol. 2019 Apr 1;5(4):579.
- Ma Y, Yang W, Simon TG, Smith-Warner SA, Fung TT, Sui J, Chong D, VoPham T, Meyerhardt JA, Wen D, Giovannucci EL, Chan AT, Zhang X. Dietary patterns and risk of hepatocellular carcinoma among US men and women. Hepatology. 2018 Dec 1. doi: 10.1002/hep.30362.
- Petrick JL, Thistle JE, Zeleniuch-Jacquotte A, Zhang X, Wactawski-Wende J, Van Dyke AL, Stampfer MJ, Sinha R, Sesso HD, Schairer C, Rosenberg L, Rohan TE, Robien K, Purdue MP, Poynter JN, Palmer JR, Newton CC, Linet MS, Liao LM, Lee IM, Koshiol J, Kitahara CM, Hofmann JN, Graubard BI, Giovannucci E, Gaziano JM, Gapstur SM, Freedman ND, Chong DQ, Chan AT, Buring JE, Beane Freeman L, Campbell PT, McGlynn KA. Body Mass Index, Diabetes and Intrahepatic Cholangiocarcinoma Risk: The Liver Cancer Pooling Project and Meta-analysis. Am J Gastroenterol. 2018 Oct;113(10):1494-1505. doi: 10.1038/s41395-018-0207-4.
- Chong DQ, Banbury BL, Phipps AI, Hua X, Kocarnik J, Peters U, Berndt SI, Huang WY, Potter JD, Slattery ML, White E, Campbell PT, Harrison T, Newcomb PA, Chan AT. Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies. Cancer Med. 2018 Mar 26.
- Petrick JL, Campbell PT, Koshiol J, Thistle JE, Andreotti G, Beane-Freeman LE, Buring JE, Chan AT, Chong DQ, Doody MM, Gapstur SM, Gaziano JM, Giovannucci E, Graubard BI, Lee IM, Liao LM, Linet MS, Palmer JR, Poynter JN, Purdue MP, Robien K, Rosenberg L, Schairer C, Sesso HD, Sinha R, Stampfer MJ, Stefanick M, Wactawski-Wende J, Zhang X, Zeleniuch-Jacquotte A, Freedman ND, McGlynn KA. Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project. Br J Cancer. 2018 Mar 9.
- Simon TG, King LY, Chong DQ, Nguyen LH, Ma Y, VoPham T, Giovannucci EL, Fuchs CS, Meyerhardt JA, Corey KE, Khalili H, Chung RT, Zhang X, Chan AT. Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies. Hepatology. 2018 May;67(5):1797-1806. doi: 10.1002/hep.29660.
- Nimptsch K, Song M, Aleksandrova K, Katsoulis M, Freisling H, Jenab M, Gunter MJ, Tsilidis KK, Weiderpass E, Bueno-De-Mesquita HB, Chong DQ, Jensen MK, Wu C, Overvad K, Kühn T, Barrdahl M, Melander O, Jirström K, Peeters PH, Sieri S, Panico S, Cross AJ, Riboli E, Van Guelpen B, Myte R, Huerta JM, Rodriguez-Barranco M, Quirós JR, Dorronsoro M, Tjønneland A, Olsen A, Travis R, Boutron-Ruault MC, Carbonnel F, Severi G, Bonet C, Palli D, Janke J, Lee YA, Boeing H, Giovannucci EL, Ogino S, Fuchs CS, Rimm E, Wu K, Chan AT, Pischon T. Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies. Eur J Epidemiol. 2017 May;32(5):419-430.
- Kocarnik JM, Chan AT, Slattery ML, Potter JD, Meyerhardt J, Phipps A, Nan H, Harrison T, Rohan TE, Qi L, Hou L, Caan B, Kroenke CH, Strickler H, Hayes RB, Schoen RE, Chong DQ, White E, Berndt SI, Peters U, Newcomb PA. Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage- specific associations.Int J Cancer. 2016 Sep 1;139(5):1065-72.
- Chong DQ, Manalo M, Imperial M, Teo P, Yong G, Ng M, Tan IB, Choo SP, Chua C.Safety and efficacy of aflibercept in combination with fluorouracil, leucovorin and irinotecan in the treatment of Asian patients with metastatic colorectal cancer. Asia Pac J Clin Oncol. 2016 Sep;12(3):275-83.
- Campbell PT, Newton CC, Freedman ND, Koshiol J, Alavanja MC, Beane Freeman LE, Buring JE, Chan AT, Chong DQ, Datta M, Gaudet MM, Gaziano JM, Giovannucci EL, Graubard BI, Hollenbeck AR, King L, Lee IM, Linet MS, Palmer JR, Petrick JL, Poynter JN, Purdue MP, Robien K, Rosenberg L, Sahasrabuddhe VV, Schairer C, Sesso HD, Sigurdson AJ, Stevens VL, Wactawski-Wende J, Zeleniuch-Jacquotte A, Renehan AG, McGlynn KA. Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults. Cancer Res. 2016 Oct 15;76(20):6076-6083.
- Kocarnik JM, Chan AT, Slattery ML, Potter J, Meyerhardt J, Phipps A, Nan H, Harrison T, Rohan TE, Qi L, Hou L, Caan B, Kroenke CH, Strickler H, Hayes RB, Schoen RE, Chong DQ, White M, Berndt S, Peters U, Newcomb PA. Relationship of pre-diagnostic body mass index with survival after colorectal cancer: Stage-specific associations. Int J Cancer. 2016 Apr 28. doi: 10.1002/ijc.30163.
- Chong DQ, Manalo M, Imperial M, Teo P, Yong G, Ng M, Tan IB, Choo SP, Chua C. Safety and efficacy of aflibercept in combination with fluorouracil, leucovorin and irinotecan in the treatment of Asian patients with metastatic colorectal cancer. Asia Pac J Clin Oncol. 2016 Apr 14. doi: 10.1111/ajco.12496
- Petrick JL, Sahasrabuddhe VV, Chan AT, Alavanja MC, Beane-Freeman LE, Buring JE, Chen J, Chong DQ, Freedman ND, Fuchs CS, Gaziano JM, Giovannucci E, Graubard BI, Hollenbeck AR, Hou L, Jacobs EJ, King LY, Koshiol J, Lee IM, Linet MS, Palmer JR, Purdue MP, Rosenberg L, Schairer C, Sesso HD, Sigurdson AJ, Wactawski-Wende J, Zeleniuch-Jacquotte A, Campbell PT, McGlynn KA. NSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project. Cancer Prev Res (Phila). 2015 Dec;8(12):1156-62
- Chong DQ, Mehta RS, Song M, Kedrin D, Meyerhardt JA, Ng K, Wu K, Fuchs CS, Giovannucci EL, Ogino S, Chan AT. Prediagnostic Plasma Adiponectin and Survival among Patients with Colorectal Cancer. Cancer Prev Res (Phila). 2015 Dec;8(12):1138-45.
- Petrick JL, Freedman ND, Graubard BI, Sahasrabuddhe VV, Lai GY, Alavanja MC, Beane-Freeman LE, Boggs DA, Buring JE, Chan AT, Chong DQ, Fuchs CS, Gapstur SM, Gaziano JM, Giovannucci EL, Hollenbeck AR, King LY, Koshiol J, Lee IM, Linet MS, Palmer JR, Poynter JN, Purdue MP, Robien K, Schairer C, Sesso HD, Sigurdson AJ, Zeleniuch-Jacquotte A, Wactawski-Wende J, Campbell PT, McGlynn KA. Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project. Cancer Epidemiol Biomarkers Prev. 2015 Sep;24(9):1398-406.
- Mehta RS, Chong DQ, Song M, Meyerhardt JA, Ng K, Nishihara R, Qian Z, Morikawa T, Wu K, Giovannucci EL, Fuchs CS, Ogino S, Chan AT. Association Between Plasma Levels of Macrophage Inhibitory Cytokine-1 Before Diagnosis of Colorectal Cancer and Mortality. Gastroenterology. 2015 Sep;149(3):614-22.
- Goyal L, Govindan A, Sheth RA, Nardi V, Blaszkowsky LS, Faris JE, Clark JW, Ryan DP, Kwak EL, Allen JN, Murphy JE, Saha SK, Hong TS, Wo JY, Ferrone CR, Tanabe KK, Chong DQ, Deshpande V, Borger DR, Iafrate AJ, Bardeesy N, Zheng H, Zhu AX. Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma. Oncologist. 2015 Sep;20(9):1019-27.
- Chong DQ, Toh XY, Ho IA, Sia KC, Newman JP, Yulyana Y, Ng WH, Lai SH, Ho MM, Dinesh N, Tham CK, Lam PY. Combined treatment of Nimotuzumab and rapamycin is effective against temozolomide-resistant human gliomas regardless of the EGFR mutation status. BMC Cancer. 2015 Apr 11;15:255.
- Foo AS, Lim C, Chong DQ, Tan DY, Tham CK. Primary intracranial germ cell tumours: experience of a single South-East Asian institution. J Clin Neurosci. 2014 Oct;21(10):1761-6.
- Chuan Aaron FS, Dawn CQ, Kenneth CT, Hoe NW, Yen SS, Chee Kian T. Primary human chorionic gonadotropin secreting germinoma of the corpus callosum. Surg Neurol Int. 2013 Oct 8;4:137.
- Tham CK, See SJ, Tan SH, Lim KH, Ng WH, Thomas J, Chong DQ, Chua ET. Combined temozolomide and radiation as an initial treatment for anaplastic glioma. Asia Pac J Clin Oncol. 2013 Sep;9(3):220-5.
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Research Trials
- A Randomized Phase 3 Study of MRTX849 in Combination with Cetuximab Versus Chemotherapy in Patients with Advanced Colorectal Cancer with KRAS G12C Mutation with Disease Progression On or After Standard First-Line Therapy (Principal Investigator)
- Diet-derived metabolites and the risk of colorectal cancer: a nested case-control study in a population-based cohort, the Singapore Chinese Health Study (NMRC TA)
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