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Clin Asst Prof Chay Wen Yee

MBBS, M Med (Internal Med), MRCP (UK), FAMS

Senior Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology

Sub-specialties: Breast, Gynae-Oncology

Conditions Treated by this Doctor:
Breast Cancer , Gynaecological Cancers, Ovarian Cancer, Uterine Cancer.

Clinical Appointments

  • Senior Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Visiting Consultant KK Gynaecological Cancer Centre KK Women's and Children's HospitalKK Women's and Children's Hospital

Academic Appointments

  • Clinical Asst Professor SingHealth Duke-NUS Oncology Academic Clinical Programme
  • Adjunct Clinical Instructor


Dr Wen-Yee Chay is a Senior Consultant in the Department of Medical Oncology at National Cancer Centre Singapore, and Visiting Consultant at KK Women’s and Children’s Hospital. She obtained her undergraduate medical degree from the National University of Singapore, and is a Member of the Academy of Medicne, Singapore. 
After completing her postgraduate specialist training in Medical Oncology in Singapore, Dr Chay has been practising in Singapore since 2011, focusing mainly on gynecological cancers and breast cancer. Her research interests include identification of potential biomarkers in the ovarian cancer and she is involved in several ongoing clinical trials. Dr Chay plays an active role in both undergraduate and post graduate education. She is an Adjunct Clinical Instructor with Yong Loo Lin School of Medicine, National University of Singapore and is also a member of the core faculty for Singhealth Senior Oncology Residency Programme.
As the Co-chair of Patient Support at NCCS, Dr Chay also participates actively in various patient support groups’ activities and programs.


  • MBBS
  • MRCP (UK)
  • M.Med ( Int Med)
  • FAMS

Professional Appointments and Committee Memberships

  • Co-chair, Patient Support Programme, NCCS 2013-current 
  • Member - Singapore Medical Association May 2005 - current 
  • Member - Singapore Society of Oncology March 2010 - current 
  • Member - Academy of Medicine Singapore July 2012- current 


  • SingHealth Best Medical Officer Award 2008 
  • FY 2014 Health Manpower Development Plan ( HMDP ) Clinical Fellowship in Comprehensive Gynaecology Oncology, BC Cancer Agency, Vancouver, Canada

Research Interests


  • Chay WY, McCluggage WG, Lee CH, Köbel M, Irving J, Millar J, Gilks CB, Tinker AV. Outcomes of Incidental Fallopian Tube High-Grade Serous Carcinoma and Serous Tubal Intraepithelial Carcinoma in Women at Low Risk of Hereditary Breast and Ovarian Cancer. Int J Gynecol Cancer. 2016 Mar;26(3):431-6. doi: 10.1097/IGC.0000000000000639 
  • Tan HS, Tan MH, Chow KY, Chay WY, Lim WY.Reproductive factors and lung cancer risk among women in the Singapore Breast Cancer Screening Project. Lung Cancer. 2015 Dec;90(3):499-508. doi: 10.1016/j.lungcan.2015.10.003. Epub 2015 Oct 8. 
  • Gay GM, Lim JS, Chay WY, Chow KY, Tan MH, Lim WY. Reproductive factors, adiposity, breastfeeding and their associations with ovarian cancer in an Asian cohort. Cancer Causes Control. 2015 Nov;26(11):1561-73. doi: 10.1007/s10552-015-0649-6. Epub 2015 Sep 5. 
  • Lee CP, Choi H, Soo KC, Tan MH, Chay WY, Chia KS, Liu J, Li J, Hartman M. Mammographic Breast Density and Common Genetic Variants in Breast Cancer Risk Prediction. PloS one. 2015 Sep 24;10(9):e0136650.  
  • Chay WY, Horlings HM, Tinker AV, Gelmon KA, Gilks CB. Low grade serous carcinoma of the peritoneum in a BRCA1 carrier previously diagnosed with a "low-grade serous tubal intra-epithelial carcinoma" (STIC) on risk reducing surgery. Gynecol Oncol Rep. 2015 Mar 28;12:72-4. doi: 10.1016/j.gore.2015.03.007. eCollection 2015 Apr. 
  • Cheung YT, Foo YL, Shwe M, Tan YP, Fan G, Yong WS, Madhukumar P, Ooi WS, Chay WY, Dent RA, Ang SF, Lo SK, Yap YS, Ng R, Chan A. Minimal clinically important difference ( MCID ) for functional assessment of cancer therapy: cognitive function ( FACT-Cog) in breast cancer patients. J Clin Epidemiol. 2014 Jul;67(7):811-20. doi: 10.1016/j.jclinepi.2013.12.011. Epub 2014 Mar 18. 
  • Li Xinyun, Chew Sung-Hock, Chay Wen-Yee, Lim-Tan Soo-Kim, Goh Liang-Kee. Optimizing Ventana chromogenic dual in-situ hybridization for mucinous epithelial ovarian cancer. BMC research notes. 2013 Dec 1;6(1):1-9. 
  • Chay WY, Chew SH, Ong WS, Busmanis I, Li X, Thung S, Ngo L, Lim SL, Lim YK, Chia YN, Koh E, Pang C, Soh LT, Wang J, Ho TH, Tay SK, Lim-Tan SK, Lim KH, Chia JW, Goh LK. HER2 amplification and clinicopathological characteristics in a large Asian cohort of rare mucinous ovarian cancer. PLoS One. 2013 April 19:8(4) e61565.
  • I Cima, WY Chay, FS Iliescu, WM Phyo, KH Lim, C IIiescu, MH Tan. Label-free isolation of circulating tumor cells in microfluidic devices : Current research and perspectives. Biomicrofluidics. 01/2013; 7(1): 011810. DOI: 10.1063 
  • Cheung YT, Shwe M, Chui WK, Chay WY, Ang SF, Dent RA, Yap YS, Lo SK, N RC, Chan A. Effects of chemotherapy and psychosocial distress on perceived cognitive disturbances in Asian breast cancer patients. Ann Pharmacother. 2012 Dec :46(12): 1645-55

Research Trials

  • Collection of Tissue for - Molecular Analysis, Immune Analysis and the generation of tumour lysates and cell lines for Gynaecologic Malignancies