Clin Assoc Prof Tuan Kit Loong Jeffrey

MBBS (Singapore), MSc (UK), FRCR (Clinical Oncology) (UK), FAMS

Senior Consultant, Research Director

National Cancer Centre Singapore

Specialty: Radiation Oncology

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About

Education and Training

Professional Appointments and Committee Memberships

Awards

Research Interests

Research Trials

Publications

Conditions Treated By This Doctor

Bladder Cancer Cervical Cancer Kidney Cancer Ovarian Cancer Prostate Cancer Testicular Cancer Uterine Cancer

Clinical Interests

Gynae-Oncology, Uro-Oncology

Clinical Appointments

Senior Consultant, Research Director
Head, Department of Gastrointestinal Hepato-pancreato-biliary and Urology

Radiation Oncology

Visiting Consultant

Urology

Visiting Consultant

KK Gynaecological Cancer Centre

Academic Appointments

Clinical Associate Professor

Oncology Academic Clinical Programme

About

Dr. Jeffrey Tuan is Head and Senior Consultant Radiation Oncologist of the Department of Gastrointestinal Hepato-Pancreato-Biliary and Urology and Research Director in the Division of Radiation Oncology at the National Cancer Centre Singapore. His clinical interests are in managing patients with Urological and Gyne-cological cancers using advanced radiation therapy techniques such as Intensity Modulated Volumetric Arc Radiotherapy, Stereotactic Body Radiotherapy (SBRT) and LDR/HDR Brachytherapy. His current research interests are in intra-fractional tumor tracking, focal therapy in prostate cancer and identifying potential bi-omarkers in radiation sensitivity. He holds a concurrent appointment as a Clinical Associate Professor within the Oncology Academic Clinical Program in Duke – National University Singapore (Duke-NUS) and Clinical Teacher of the Nanyang Technological University Lee Kong Chian (NTU LKC) School of Medicine. He spent four years training and pursuing academic research in both the United Kingdom and Italy in the fields of Clinical Oncology and Particle Beam Therapy. More recently as the Technical Lead, he is actively involved in the planning and setting up of the new Proton Beam Therapy Centre co-located at the new National Cancer Centre Singapore to be ready in 2022-3.

Education and Training

MSc (University of London) 2009
FRCR Royal College of Radiologists, UK 2009
MBBS (National University of Singapore) 2000

Professional Appointments and Committee Memberships

Member, Singapore Cancer Society (SCS) Prostate Survivorship Advisory Board
Chairman, 2021 SCS prostate cancer awareness month (PCAM)

Awards

HMDP to Royal Marsden Hospital London UK for clinical oncology 2007-2009
EU Marie Curie Fellow in particle therapy, PARTNER network, Fondazione CNAO, Pavia Italy 2010-2012

Research Interests

Brachytherapy in prostate and gynecological cancers
Hypo fractionated radiotherapy and stereotactic body radiotherapy (SBRT)
Rectal spacer to reduce radiation proctitis and cost effectiveness analysis (CEA)
Proton Beam Therapy
Artificial Intelligence (AI) based auto segmentation and auto contouring of prostate and dominant intra prostatic lesions (DIL)
Trans perineal Ultrasound imaging of the prostate for localization and tracking
Trigger imaging and fiducials for prostate tracking
ADT related cardiotoxicity in prostate cancer

Research Trials

Outcomes Research in cancer care
Stereotactic body radiotherapy (SBRT) in prostate cancer
Low dose rate (LDR) brachytherapy in prostate cancer
High dose rate (HDR) brachytherapy in prostate cancer
Feasibility of dominant prostatic lesion (DIL) boosting/dose escalation with proton beam therapy

Publications

Tan JSH, Teh JYH, Tan LLY, Tan SXF, Li YQ, Tan TWK, Wang MLC, Kanesvaran R, Ong EHW, Tay KJ, Lee LS, Tuan JKL, Tan DYH, Chua MLK. Efficacy, toxicity, and \quality-of-life outcomes of ultrahypofractionated radiotherapy in patients with localized prostate cancer: A single-arm phase 2 trial from Asia. Asia Pac J Clin Oncol. 2021 Dec 14. doi: 10.1111/ajco.13742. Epub ahead of print. PMID:34908240.
Ong A, Knight K, Panettieri V, Dimmock M, Tuan JKL, Tan HQ, Master Z, Wright C. Application of an automated dose accumulation workflow in high-risk prostate cancer - validation and dose-volume analysis between planned and delivered dose. Med Dosim. 2021 Nov 2:S0958-3947(21)00084-4. doi: 10.1016/j.meddos.2021.09.004.Epub ahead of print. PMID: 34740517.
Tan YG, Quek SZH, Huang HH, Ho HSS, Yuen JSP, Tay KJ, Tuan JKL, Chen K. Serum testosterone levels and testosterone 'bounce' phenomenon predict response to novel anti-androgen therapies in castration-resistant prostate cancer. Urol Oncol. 2021 Dec;39(12):829.e9-829.e17. doi: 10.1016/j.urolonc.2021.04.009. Epub 2021 May 20. PMID: 34023195.
Wong SMM, Sin SY, Lim LH, Nurul Tassha BMA, Lin J, Melissa K, Koh WY, Ho F, Quah DSC, Sommat K, Tuan JKL, Wong FY, Ng WL, Yeo RMC, Soong YL, Wang MLC. The implementation of an advanced practice radiation therapy (APRT) program in Singapore. Tech Innov Patient Support Radiat Oncol. 2021 Mar 18;17:63-70. doi: 10.1016/j.tipsro.2021.02.002. PMID: 34007909; PMCID: PMC8111035.
Tey J, Ho F, Koh WY, Chia D, Ooi KH, Tuan JKL, Vellayappan B, Soon YY.Palliative radiotherapy for bladder cancer: a systematic review and meta-analysis. Acta Oncol. 2021 May;60(5):635-644. doi: 10.1080/0284186X.2021.1880025. Epub 2021 Feb 16. PMID: 33591843.
Kiljunen T, Akram S, Niemelä J, Löyttyniemi E, Seppälä J, Heikkilä J,Vuolukka K, Kääriäinen OS, Heikkilä VP, Lehtiö K, Nikkinen J, Gershkevitsh E, Borkvel A, Adamson M, Zolotuhhin D, Kolk K, Pang EPP, Tuan JKL, Master Z, Chua MLK, Joensuu T, Kononen J, Myllykangas M, Riener M, Mokka M, Keyriläinen J. A Deep Learning-Based Automated CT Segmentation of Prostate Cancer Anatomy for Radiation Therapy Planning-A Retrospective Multicenter Study. Diagnostics (Basel). 2020 Nov 17;10(11):959. doi: 10.3390/diagnostics10110959. PMID:33212793; PMCID: PMC7697786.
Ong A, Knight K, Panettieri V, Dimmock M, Tuan JKL, Tan HQ, Master Z, Wright C. Development of an automated radiotherapy dose accumulation workflow for locally advanced high-risk prostate cancer - A technical report. J Med Radiat Sci. 2021 Jun;68(2):203-210. doi: 10.1002/jmrs.442. Epub 2020 Oct 15. PMID: 33058720; PMCID: PMC8168070.
Pang EPP, Knight K, Leung RW, Wang MLC, Chan JWS, Low GK, Seah IKL, Atan MAB, Chai JYH, Ng GC, Yang TC, Tuan JKL. Technical considerations for positioning and placement of a transperineal ultrasound probe during prostate radiotherapy. J Med Radiat Sci. 2021 Jun;68(2):196-202. doi: 10.1002/jmrs.439. Epub 2020 Oct 5. PMID: 33017863; PMCID: PMC8168066.
Ng KYY, Zhou S, Tan SH, Ishak NDB, Goh ZZS, Chua ZY, Chia JMX, Chew EL, Shwe T, Mok JKY, Leong SS, Lo JSY, Ang ZLT, Leow JL, Lam CWJ, Kwek JW, Dent R, Tuan J, Lim ST, Hwang WYK, Griva K, Ngeow J. Understanding the Psychological Impact of COVID-19 Pandemic on Patients With Cancer, Their Caregivers, and Health Care Workers in Singapore. JCO Glob Oncol. 2020 Oct;6:1494-1509. doi: 10.1200/GO.20.00374. PMID: 33017179; PMCID: PMC7640379.
Tan BF, Tuan JKL, Yap SP, Ho SZ, Wang MLC. Managing the COVID-19 Pandemic as a National Radiation Oncology Centre in Singapore. Clin Oncol (R Coll Radiol). 2020 Jul;32(7):e155-e159. doi: 10.1016/j.clon.2020.04.006. Epub 2020 Apr 23.PMID: 32359846; PMCID: PMC7177121.
Tey J, Ho S, Choo BA, Ho F, Yap SP, Tuan JKL, Leong CN, Cheo T, Sommat K, Wang MLC. Navigating the challenges of the COVID-19 outbreak: Perspectives from the radiation oncology service in Singapore. Radiother Oncol.2020 Jul;148:189-193. doi: 10.1016/j.radonc.2020.03.030. Epub 2020 Mar 31. PMID: 32342873; PMCID: PMC7118656.
Pang EPP, Knight K, Park SY, Lian W, Master Z, Baird M, Chan JWX, Wang MLC, Tan TWK, Chua MLK, Chua ET, Looi WS, Nei WL, Tuan JKL. Duration-dependent margins for prostate radiotherapy-a practical motion mitigation strategy. Strahlenther Onkol. 2020 Jul;196(7):657-663. doi: 10.1007/s00066-019-01558-y.Epub 2020 Jan 13. PMID: 31932995.
Tan JSH, Goh CXY, Koh YS, Li Y, Tuan JKL, Chua ET, Tan TWK, Wang MLC, Lee LS, Tay KJ, Kanesvaran R, Toh CK, Tong AKT, Lam WWC, Chua MLK. <sup>68</sup>Gallium-labelled PSMA-PET/CT as a diagnostic and clinical decision-making tool in Asian prostate cancer patients following prostatectomy. Cancer Biol Med. 2019 Feb;16(1):157-166. doi: 10.20892/j.issn.2095-3941.2018.0288. PMID: 31119056; PMCID: PMC6528443.
Ong ALK, Ang KW, Master Z, Wong SMM, Tuan JKL. Intensity-modulated radiotherapy for whole pelvis irradiation in prostate cancer: A dosimetric andplan robustness study between photons and protons. Tech Innov Patient Support Radiat Oncol. 2018 Apr 3;6:11-19. doi: 10.1016/j.tipsro.2018.02.001. PMID: 32095573; PMCID: PMC7033791.
Pang EPP, Knight K, Fan Q, Tan SXF, Ang KW, Master Z, Mui WH, Leung RW, Baird M, Tuan JKL. Analysis of intra-fraction prostate motion and derivation ofduration-dependent margins for radiotherapy using real-time 4D ultrasound. Phys Imaging Radiat Oncol. 2018 Mar 28;5:102-107. doi: 10.1016/j.phro.2018.03.008. PMID: 33458378; PMCID: PMC7807728.