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Assoc Prof Yong Wei Sean

Assoc Prof Yong Wei Sean

MBBS, FRCS (Gen Surg)(Glas), FRCS (Gen Surg)(Ed), FAMS

Senior Consultant

National Cancer Centre Singapore

Specialty: Surgery & Surgical Oncology, General Surgery

Sub-specialties: Breast, Surgical Oncology, Breast Surgery

Conditions Treated by this Doctor:
Breast Cancer.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Breast Centre
  • Senior Consultant Breast Surgery Singapore General HospitalSingapore General Hospital
  • Senior Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore
  • Deputy Chairman, Surgical Oncology, National Cancer Centre Singapore

Academic Appointments

  • Clinical Associate Professor at Duke-NUS Medical School


​Dr Yong Wei Sean graduated from NUS and subsequently trained in general surgery, obtaining FRCS in 1997. He developed a special interest in breast surgical oncology and did a fellowship in Toronto, Canada in 2002/03.

Dr Yong is currently practicing breast and general surgery, performing diagnostic breast biopsies, therapeutic breast cancer surgery including skin sparing mastectomy and sentinel lymph node biopsy. He also has interest in sentinel node biopsy for melanoma.


  • MBBS
  • FRCS (Gen Surg)(Glas)
  • FRCS (Gen Surg)(Ed)
  • FAMS

Professional Appointments and Committee Memberships

  • Senior Consultant, Surgical Oncology, NCCS
  • Visiting Consultant, General Surgery, SGH
  • Adjunct Associate Professor, NUS Yong Loo Lin School of Medicine
  • Clinical Associate Professor, Duke-NUS Medical School


(A) Academic / Clinical Awards

2021 Long Service Medal (NCCS)

Singapore Health Quality Service Awards 2020

Dean’s Award for Teaching Excellence in AY2018/2019

2018 Singapore Health Quality Service Awards 2018, Star Award

2016 NUS Special Recognition Award: Role Model to Medical Graduating
Class of 2016

2014 Long Service Award (NCCS) – 20 years
Best Tutor for Surgery (SGH)
NUS Certificate of Award: Best Tutor for Surgery (SGH)
Service With a Heart Award (SGH)
Singapore Medical Journal: 2008 Recognition Award for Reviewing with Distinction 

Excellent Service Award (GOLD)
2007/ 2008
Dean’s Award for Teaching Excellence for Academic Year (NUS)
Singapore Medical Journal: 2007 Recognition Award for Reviewing with Distinction
HealthCare Humanity Award
Sir James Fraser Travelling Fellowship (RCS Edinburgh)
Minister for Health Award, Tsunami Relief, Indonesia
HMDP (Ministry of Health)
ASEAN scholar
(B) Others

AM Lead 3rd Cohort 2017/18

HaPEE 4 modules (2016 – 2018)

Research Interests

  • Sentinel lymph node biopsy in breast cancer
  • Melanoma


​1.    Y Ng, V Tan, Wan SP, J Chang, Sim YR, Ong KW, Yong WS, P Madhukumar, Wong CY, Ong YS, Tan BK, B Tan. Surgical and oncological safety of nipple-sparing mastectomy in an Asian population. Breast Cancer. Breast Cancer 2018 Sep 14.

2.    Sim Y, Tan VKM, Sidek NAB, Chia DKA, Tan BKT, Madhukumar P., Yong WS, Ong KW. Bilateral breast cancers in an Asian population, and a comparison between synchronous and metachronous tumours. ANZ J Surg 2018 Oct; 88(10): 982 – 987

3.    Hamzah JLB, Tan BKT, Tan VK, Madhukumar P, Lim SZ, Sim Y, Yong WS, Lee ZJ, Ong KW. A pilot study comparing Sentimag/Sienna versus standard modality for sentinel lymph node identification in patients with breast cancer. The Breast Journal Oct 2019 DOI: 10.1111/tbj.13660

4.    Nasir NDM , Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VK, Wong CY, Yong WS, Ho GH, Ong KW. Genomic characterisation of breast fibroepithelial lesions in an international cohort. International Fibroepithelial Consortium, Patrick Tan P, The BT, Tan PH. Journal of Pathology DOI: 10.1002/path.5333

5.    Loke SY, P Munusamy, Koh GL, Chan CHT, P Madhukumar, Thung JL, Tan BKT, Ong KW, Yong WS, Sim Y, Oey CL, Lim SZ, Chan PMY, Ho JTS, Khoo JBK, Wong JSL, Thng CH, Chong BK, Tan EY, Tan VKM, Lee ASG. A circulating miRNA signature for stratification of breast lesions among women with abnormal screening mammograms (Manuscript). MDPI Cancers 2019

6.    Impact of hormonal status on ductal carcinoma in situ of the breast: Outcome and prognostic factors. Tay THC, Ng WY, Ong KW, Wong CY, Tan BKT, Yong WS, Madhukumar P, Tan VKM, Lim SZ, Sim Y Breast J. 2020; 26: 937– 945.

7.    Hamzah JL, Tan BKT, Tan VKM, Preetha M, Lim SZ, Sim YR, Yong WS, Lee ZJ, Ong KW. A Pilot Study Comparing Sentimag/Sienna Versus Standard Modality for Sentinel Lymph Node Identification in Patients With Breast Cancer. Breast J. 2020 May; 26(5): 1074-1077 doi: 10.1111/tbj 13660

8.    CCY Ng,D Nasir, BN Loke, TKY Tay, AA Thike, V Rajasegaran, W Liu, JY Lee, P Guan, AH Lim, KTE  C, MA Gudi, P Madhukumar, BKT Tan, VKM Tan, CY Wong, WS Yong, GH Ho, KW Ong, International Fibroepithelial Consortium,  GWC Yip, BH Bay, P Tan, BT Teh, PH Tan. Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing.  Modern Pathology.

9.    Lim SZ, Kusumawidjaja G, Mohd Ishak HM, Tan BKT, Tan SY, Hamzah JL, Madhukumar P, Yong WS, Wong CY, Sim Y, Lim GH, Lim SH, Tan SM, Wong FY, Tan VKM. Outcomes of Stage I and II Breast Cancer with Nodal Micrometastases Treated with Mastectomy without Axillary Therapy. Breast Cancer Res Treat. 2021 Oct;189(3):837-843. doi: 10.1007/s10549-021-06341-1. Epub 2021 Aug 3.

10.  Choo PZQ, Loh AHL, Selvarajan S, Tan PH, Tan VKM, Yong WS, Leong LCH. Breast-related extranodal Rosai-Dorfman disease presenting as subcutaneous masses with thick hyperechoic rim, with review of the literature. Breast J. 2021 Aug 31. doi: 10.1111/tbj.14286. Epub ahead of print.

11.  Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, Yeo JZZ, Yuan J, Ho YY, Peh EKL, Muniandy M, Torta F, Chan J, Tan TJ, Sim Y, Tan V, Tan B, Madhukumar P, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH, Tam WL. Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Sci Adv. 2021 Oct 8;7(41):eabh2443. doi: 10.1126/sciadv.abh2443. Epub 2021 Oct 6.

12.  Chiam M, Ho CY, Quah E, Chua KZY, Ng CWH, Lim EG, Tan JRM, Wong RSM, Ong YT, Soong YL, Kwek JW, Yong WS, Loh KWJ, Lim C, Mason S, Krishna LKR. Changing self-concept in the time of COVID-19: a close look at physician reflections on social media. Philos Ethics Humanit Med. 2022 Jan 26;17(1):1. doi: 10.1186/s13010-021-00113-x. PMID: 35078488; PMCID: PMC8789479.

13.  Bong TSH, Tan JKT, Ho JTS, Tan PH, Lau WS, Tan TM, Wong JSL, Tan VKM, Tan BKT, Madhukumar P, Yong WS, Lim SZ, Wong CY, Ong KW, Sim Y. Atypical Ductal Hyperplasia of the Breast on Core Needle Biopsy: Risk of Malignant Upgrade on Surgical Excision. J Breast Cancer. 2022 Feb;25(1):37-48. doi: 10.4048/jbc.2022.25.e7. PMID: 35199500; PMCID: PMC8876544.

14.  Lim JT, Koh JJE, Ho PJ, Liu J, Lim SH, Tan EY, Tan BKT, Tan VKM, Tan SM, Yong WS, Hartman M, Chen C. Impact of Subsidy on the Use of Personalized Medicine in Breast Cancer. Value Health Reg Issues. 2022 Jan 29;29:108-115. doi: 10.1016/j.vhri.2021.10.002. Epub ahead of print.

15.  Sim Y, Lim C, Phyu N, Tan KTB, Chew LST, Wong CY, Madhukumar P, Yong WS, Lim SZ, Hamzah JLB, Tan SY, Chay WY, Wong FY, Tan PH and Tan VKM. The Impact of Statin Use and Breast Cancer Recurrence - A Retrospective Study in Singapore. Front. Oncol. 12:835320. doi: 10.3389/fonc.2022.835320

Research Trials