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Asst Prof Preetha Madhukumar

Asst Prof Preetha Madhukumar

MBBS, M Med (Surgery), FRCS, FAMS

Senior Consultant

National Cancer Centre Singapore

Specialty: Surgery & Surgical Oncology

Clinical Interest: Breast, Breast Surgery

Conditions Treated by this Doctor:
Breast Cancer.

Clinical Appointments

  • Senior Consultant SingHealth Duke-NUS Breast Centre
  • Senior Consultant Breast Surgery Singapore General HospitalSingapore General Hospital
  • Senior Consultant Division of Surgery & Surgical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore

Academic Appointments

  • Assistant Professor
  • Senior Clinical Lecturer


Dr Madhukumar is a Senior Consultant surgeon in Singhealth Duke-NUS Breast Centre under Division of Surgical Oncology. She obtained her MBBS and Master of Surgery degree from India. She obtained FRCS from Royal College of surgeons, Glasgow in 1998. She started working in Singapore from 1999 and obtained her FAMS and specialist accreditation in Surgery in 2004. 

Since then she was working in Department of General Surgery, Singapore General Hospital (SGH) before joining National Cancer Centre Singapore, Department of Surgical Oncology. Her main interest is in breast cancer surgery including screening and detection, surgical management and follow up. She is also senior consultant in the trauma service under Division of General Surgery, SGH. Apart from the clinical interest she is very active in the educational field. She is a pioneer fellow of AMEI. She is actively involved in teaching medical students, residents, fellows and allied health professionals. 

She is also actively involved in breast cancer research activities.


  • FAMS; Academy of Medicine, Singapore, 2004 
  • FRCS; Royal College of Surgeons, Glasgow, 1998 
  • MS (General Surgery); Government Medical College, Trivandrum, Kerala University, 1993 
  • M.B,B.S; Government Medical College, Trivandrum, Kerala University, 1990

Professional Appointments and Committee Memberships

  • Chairperson Infection Control Committee , National Cancer Centre, Singapore


  • Care Excellence award, NCCS 2011 
  • Service with a Heart Award, SGH 2011 
  • NUS YLLSoM Clinical Faculty Scheme; Dean’s Award, NUS 2010/11 
  • Outstanding Faculty for Advocacy (Surgery) Faculty Appreciation Award, Duke-NUS 2011

Research Interests


  1. Chan CHT, Munusamy P, Loke SY, Koh GL, Yang AZY, Law HY, Yoon CS, Wong CY, Yong WS, Wong NS, Ng RCH, Ong KW, Madhukumar P, Oey CL, Ho GH, Tan PH, Tan MH, Ang P, Yan YS, Lee ASG. Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese. Oncotarget. 2018 Jan 31; 9(16): 12796-12804. doi: 10.18632/oncotarget.24374. eCollection 2018 Feb 27.
  2. W. Q. Lee, V. K. M. Tan, H. M. C. Choo, J. Ong, R. Krishnapriya, S. Khong, M. Tan, Y. R. Sim, B. K. Tan, P. Madhukumar, W. S. Yong and K. W. Ong. Factors influencing patient decision-making between simple-mastectomy and surgical alternatives.  Wiley Online Library. DOI: 10.1002/bjs5.50105. 21 August 2018        
  3. Ng YY, Tan VK, Pek WS, Chang JH, Sim Y, Ong KW, Yong WS, Madhukumar P, Wong CY, Ong YS, Tan BK, Tan BKT. Surgical and oncological safety of nipple-sparing mastectomy in an Asian population. Breast Cancer. Breast Cancer. 2019 Mar; 26(2): 165-171. doi: 10.1007/s12282-018-0908-y. Epub 2018 Sep 14.       
  4. Sim Y, Tan VKM, Sidek NAB, Chia DKA, Tan BKT, Madhukumar P, Yong WS, Wong CY, Ong KW.  Bilateral breast cancers in an Asian population, and a comparison between synchronous and metachronous tumours. ANZ J Surg. 2018 Oct; 88(10): 982-987. doi: 10/1111/ans.14773. Epub 2018 Aug 23.   
  5. Sim Y, Ng GXP, Ng CCY, Rajasegaran V, Wong SF, Liu W, Guan P, Nagarajan S, Ng WY, Thike AA, Lim JCT, Nasir NDB, Tan VK, Madhukumar P, Yong WS, Wong CY, Tan BKT, Ong KW, The BT, Tan PH. A Novel Genomic Panel as an Adjunctive Diagnostic Tool for the Characterization and Profiling of Breast Fibroepithelial Lesions (Manuscript). BMC Medical Genomics (Open) Oct 2019
  6. Hamzah JLB, Tan BKT, Tan VK, Madhukumar P, Lim SZ, Sim Y, Yong WS, Lee ZJ, Ong KW. A pilot study comparing Sentimag/Sienna versus standard modality for sentinel lymph node identification in patients with breast cancer. The Breast Journal Oct 2019 DOI: 10.1111/tbj.13660
  7. Nasir NDM , Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VK, Wong CY, Yong WS, Ho GH, Ong KW. International Fibroepithelial Consortium, Patrick Tan P, The BT, Tan PH. Genomic characterisation of breast fibroepithelial lesions in an international cohort. Journal of Pathology DOI: 10.1002/path.5333
  8. Loke SY, P Munusamy, Koh GL, Chan CHT, P Madhukumar, Thung JL, Tan BKT, Ong KW, Yong WS, Sim Y, Oey CL, Lim SZ, Chan PMY, Ho JTS, Khoo JBK, Wong JSL, Thng CH, Chong BK, Tan EY, Tan VKM, Lee ASG. A circulating miRNA signature for stratification of breast lesions among women with abnormal screening mammograms (Manuscript). MDPI Cancers 2019
  9. Tay THC, Ng WY, Ong KW, Wong CY, Tan BKT, Yong WS, Madhukumar P, Tan VKM, Lim SZ, Sim Y. Impact of hormonal status on ductal carcinoma in situ of the breast: Outcome and prognostic factors. Breast J. 2020; 26: 937– 945.
  10. Wong FY, Wong RX, Zhou S, Ong WS, Pek PP, Yap YS, Tan BKT, Ngeow JYY, Tan VKM, Sim Y, Tan SM, Lim SH, Madhukumar P, Tan TJY, Loh KWJ, Ong MEH, Wong TH, Joint Breast. Effects of housing value and medical subsidy on treatment and outcomes of breast cancer patients in Singapore: A retrospective cohort study. Lancet. 2020 Dec 8; 6(100065). doi:
  11. CCY Ng,D Nasir, BN Loke, TKY Tay, AA Thike, V Rajasegaran, W Liu, JY Lee, P Guan, AH Lim, KTE  C, MA Gudi, P Madhukumar, BKT Tan, VKM Tan, CY Wong, WS Yong, GH Ho, KW Ong, International Fibroepithelial Consortium,  GWC Yip, BH Bay, P Tan, BT Teh, PH Tan. Genetic differences between benign phyllodes tumors and fibroadenomas revealed through targeted next generation sequencing. Modern Pathology.
  12. Lim SZ, Kusumawidjaja G, Mohd Ishak HM, Tan BKT, Tan SY, Hamzah JL, Madhukumar P, Yong WS, Wong CY, Sim Y, Lim GH, Lim SH, Tan SM, Wong FY, Tan VKM. Outcomes of Stage I and II Breast Cancer with Nodal Micrometastases Treated with Mastectomy without Axillary Therapy Breast Cancer Res Treat. 2021 Oct;189(3):837-843. doi: 10.1007/s10549-021-06341-1. Epub 2021 Aug 3.
  13. Loo SY, Toh LP, Xie WH, Pathak E, Tan W, Ma S, Lee MY, Shatishwaran S, Yeo JZZ, Yuan J, Ho YY, Peh EKL, Muniandy M, Torta F, Chan J, Tan TJ, Sim Y, Tan V, Tan B, Madhukumar P, Yong WS, Ong KW, Wong CY, Tan PH, Yap YS, Deng LW, Dent R, Foo R, Wenk MR, Lee SC, Ho YS, Lim EH, Tam WL. Fatty acid oxidation is a druggable gateway regulating cellular plasticity for driving metastasis in breast cancer. Sci Adv. 2021 Oct 8;7(41):eabh2443. doi: 10.1126/sciadv.abh2443. Epub 2021 Oct 6.
  14. Sim Y, Lim C, Phyu N, Tan KTB, Chew LST, Wong CY, Madhukumar P, Yong WS, Lim SZ, Hamzah JLB, Tan SY, Chay WY, Wong FY, Tan PH and Tan VKM. The Impact of Statin Use and Breast Cancer Recurrence - A Retrospective Study in Singapore. Front. Oncol. 12:835320. doi: 10.3389/fonc.2022.835320
  15. Tan HQ, Ong HH, Arjunan MK, Tan TJ, Tan RYC, Lee GSX, Lim EH, Ng R, Yeo RMC, Lim LFWT, Zhang Z, Yang CSH, Wong RX, Ooi GSK, Leong LCH, Tan SM, Madhukumar P, Sim Y, Tan VKM, Yeong J, Wong FY, Cai Y, Nei WL, JBCR, Ai3. Multi‑center evaluation of artificial intelligent imaging and clinical models for predicting neoadjuvant chemotherapy response in breast cancer.  Breast Cancer Research and Treatment

Research Trials

  • SLN biopsy after neo adjuvant chemotherapy: Surgical trial 
  • A multi-center, randomized, double-blinded, parallel group, placebo controlled trial to evaluate the efficacy and safety of activated recombinant factor VII (rFVII/NovoSeven/Niastase) in severely injured trauma patients with bleeding refractory to standard treatment