Skip Ribbon Commands
Skip to main content

Cancer Genomics Laboratory

​Research head:​A/Prof Caroline G. LEE
​Research team:

Dr. Lee Jin LIM 

Yong Zher KOH 

Jun Yan LOH 

Ashley LIM Jun Wei 

Tyniana Carissa Tera 

Laura GOH Shih Hui

There are three major focus in the Liver Cancer Functional Genomics Laboratory. The first is to understand the role of chronic inflammation in tumorigenesis for the development of intervention strategies. Our laboratory has identified FAT10 as a molecule that plays an important role in Hepatocellular Carcinoma and other cancers associated with chronic inflammation. We seek to further elucidate its role in modulating inflammation and metabolism during tumorigenesis and metastasis to facilitate the development of strategies targeting this molecule. 

The second major focus of the laboratory is to elucidate the role of various non-coding RNAs (including circular RNA, microRNAs and long noncoding RNAs) in hepatocellular carcinoma. Our laboratory has employed an integrative big data approach to identify clinically relevant networks of non-coding RNAs in the cancer pathway. We will characterise these networks of non-coding RNAs for their tumorigenic potential to identify novel molecular biomarkers that can be used to help detect liver cancer at an early stage more accurately, predict patient responses to specific treatments, and identify targets for therapy. 

The third major focus is in the field of Precision Medicine, where the laboratory aims to employ biologically meaning artificial intelligence (AI) and machine learning to better predict complex disease susceptibility, drug response and prognosis.

Selected publications:

  1. Ashley J.W. Lim, Lee Jin Lim, Brandon N. S. Ooi, Ee Tzun Koh, Justina Wei Lynn Tan, TTSH RA Study Group, Samuel S. Chong, Chiea Chuen Khor, Lisa Tucker-Kellogg, Khai Pang Leong, Caroline G. Lee*. (2022) Functional coding haplotypes and machine-learning feature elimination identifies predictors of Methotrexate Response in Rheumatoid Arthritis patients. EBioMedicine ( 
  2. Lee Jin Lim†, Ashley J.W. Lim†, Brandon N. S. Ooi , Justina Wei Lynn Tan, Ee Tzun Koh, TTSH Rheumatoid Arthritis Study Group, Samuel S. Chong, Chiea Chuen Khor, Lisa Tucker-Kellogg, Caroline G. Lee*, Khai Pang Leong*. (2022) Machine Learning using Genetic and Clinical Data Identifies a Signature that Robustly Predicts Methotrexate Response in Rheumatoid Arthritis. Rheumatology *co-corresponding authors. 
  3. Lee Jin Lim, Ashley Jun Wei Lim, Kevin K. Fong, Caroline G. Lee. Sentiments regarding COVID-19 Vaccination among Graduate Students in Singapore. Vaccines (2021) 9:1141-1156. 
  4. Jian Han , Thomas Thurnherr , Alexander Y.F. Chung , Brian K.P. Goh , Pierce K.H. Chow , Chung Yip Chan , Peng Chung Cheow , Ser Yee Lee , Tony K.H. Lim , Samuel S . Chong , London L.P.J. Ooi , Caroline G Lee *. Clinicopathological-associated regulatory network of deregulated circRNAs in hepatocellular carcinoma. Cancers (2021) 13, 2772. 
  5. Brandon N. S. Ooi, Raechell, Ariel F. Ying, Yong Zher Koh, Yu Jin, Sherman W. L. Yee, Justin H. S. Lee, Samuel S. Chong, Jack W. C. Tan, Jianjun Liu, Caroline G. Lee* and Chester L. Drum*. Robust performance of potentially functional SNPs in machine learning models for the prediction of atorvastatin-induced myalgia. Frontiers in Pharmacology (2021) 12:605764. doi: 10.3389/fphar.2021.605764 
  6. Lee Jin Lim, Lay Hiang Ling, Yu Pei Neo, Alexander Y.F. Chung, Brian K.P. Goh, Pierce K.H. Chow, Chung Yip Chan, Peng Chung Cheow, Ser Yee Lee, Tony K.H. Lim, Samuel S. Chong, London L.P.J.Ooi and Caroline G. Lee*. Highly deregulated lncRNA LOC is associated with overall worse prognosis in Hepatocellular Carcinoma patients. Journal of Cancer (2021) 12(11):3098-3113. doi:10.7150/jca.56340 
  7. Lee Jin Lim, Yu Jin, Henry Yang, Alexander Y.F. Chung, Brian K.P. Goh, Pierce K.H. Chow, Chung Yip Chan, William K. Blanks, Peng Chung Cheow, Ser Yee Lee, Tony K.H. Lim, Samuel S. Chong, London L.P.J.Ooi and Caroline G. Lee. Network of clinically-relevant lncRNAs-mRNAs associated with prognosis of Hepatocellular Carcinoma patients. Scientific Reports (2020) 10:11124 
  8. Maulana Bachtiar, Brandon Nick Sern Ooi, Jingbo Wang, Jin Yu, Tin Wee Tan, Samuel S. Chong, and Caroline G. L. Lee*. (2019) Towards Precision Medicine: Interrogating the Human Genome to Identify Drug Pathways Associated with Potentially Functional, Population-Differentiated Polymorphisms. The Pharmacogenomics Journal 1038/541397-019--0096-y. 
  9. Lee Jin Lim, Samuel Y.S. Wong, Feiyang Huang, Sheng Lim, Samuel Chong, London Lucien Ooi, Oi Lian Kon and Caroline G. Lee*. Roles and Regulation of Long non-coding RNAs in Hepatocellular Carcinoma. Cancer Research DOI: 10.1158/0008-5472.CAN-19-0255 (2019). 
  10. Lee Wai Yeow, Maulana Bachtiar, Chan Siew Choo, Cheryl and Caroline G Lee*. Comprehensive Review of Hepatitis B Virus-associated Hepatocellular Carcinoma Research through Text Mining and Big Data Analytics. Biol Rev Camb Philos Soc. 2019 Apr;94(2):353-367. doi: 10.1111/brv.12457. Epub 2018 
  11. Cheryl CHAN, Thomas THURNHERR, Jingbo WANG, Xavier GALLART-PALAU, Siu Kwan SZE, Steve ROZEN and Caroline G. LEE. Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. Molecular Oncology 2016 10(8):1183-1195 (2016) 
  12. Steven Setiawan Theng, Wei Wang, Way Champ Mah, Cheryl Chan, Jingli Zhuo, Yun Gao, Haina Qin, Liangzhong Lim, Samuel S. Chong, Jianxing Song and Caroline G.L. Lee*. Disruption of FAT10-MAD2 binding inhibits Tumor Progression Proc. Natl. Acad. Sci. U.S.A. 111(49):E5282-5291 (2014)