Sabrina Ngaserin, Faith Leong, Benita Kiat Tee Tan, Sim Yirong

A study to evaluate clinical-radiological-pathological concordance in patients with invasive lobular carcinoma of the breast.

Abstract Disclosures
Introduction:
Historically, invasive lobular carcinoma (ILC) of the breast has been recognised to be imaging-diffuse or occult on mammography and ultrasonography, with a propensity for multifocality, multicentricity and bilaterality. The use of breast MRI has been widely purported to improve diagnostic accuracy, however the extensive or blanket use of MRI has become a subject for debate as several recent studies have questioned its additional value in surgical (and radiation therapy) planning, as well as its relevance towards optimising disease and survival outcomes. 
 
Several questions of research interest include: 
1. Does breast MRI add value to the diagnostic workup and accuracy in ILC? 
2. Does breast MRI significantly affect surgical management when BCS can be considered? 
3. The effect of the use of breast MRI on local recurrence, disease-free and overall survival in our breast cancer patients.

Methods:
The study will review data from SingHealth Duke-NUS Breast Centre. Inclusion criteria includes patients with histologically-diagnosed invasive lobular carcinoma. Data will include patient characteristics [age, gender, ethnicity, marital status, family history of cancer], cancer characteristics [unifocal/multifocal/multicentric, laterality (unilateral/bilateral), histology (ILC, mixed IDC-ILC), grade, hormone receptor status, HER2 receptor status, subtype, stage], and surgical treatment rendered. In particular, we seek to review the rate of primary and bilateral mastectomies, surgical margins in BCS, rate of completion mastectomy in primary BCS, and false-positive rates on final histology.

Aim:
We aim to contribute to the community's understanding of the use of breast MRI and surgical decision making in patients with ILC.

Joint Breast Cancer Registry Singapore