Sabrina Ngaserin, Grace Kusumawidjaja, Faith Leong, Benita Kiat Tee Tan, Sim Yirong

Breast conserving surgery versus mastectomy: Long-term efficacy for primary operable in-situ and early-stage invasive breast cancers

Abstract Disclosures
Abstract:
Early breast cancer is often treated with index surgery, followed by subsequent loco-regional radiation and adjuvant systemic therapy, as indicated. In-situ breast cancer is often treated with loco-regional strategies. Early breast cancer is often treated with index surgery, followed by subsequent loco-regional radiation and adjuvant systemic therapy, as indicated. Randomised trials from patient’s recruited from the 1980s previously indicated that breast conserving surgery (BCS) in eligible patients was at least as effective as mastectomy in terms of local tumour control, recurrence free survival, and overall survival. Local failures consistent with new primaries had been strongly associated with BCS, whereas true recurrence predominated after mastectomy. However, more recent observational studies, population-based registry studies, and updates with extended follow up intervals, have indicated that breast-conserving surgery plus radiotherapy compared to mastectomy in early breast cancer has in fact showed improved 105 to 20 year overall and relative survival, and diversities in radiotherapy did not appear to explain the observed survival differences. This begs the critical question – Is it still appropriate to offer women with conservable early breast cancers the choice of mastectomy? We aim to contribute to the understanding of long-term local tumour control and final survival outcomes.

We aim to study disease free survival and overall survival after breast-conserving surgery compared with mastectomy in women from Singapore.

Joint Breast Cancer Registry Singapore