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Dr Chan Yong Sheng Jason from National Cancer Centre Singapore

Dr Chan Jason Yong Sheng

MBBS, MRCP (UK), M MED (Internal Medicine)

Associate Consultant

National Cancer Centre Singapore

Specialty: Medical Oncology

Sub-specialties: Lymphoma, Sarcoma, Skin & Melanoma

Conditions Treated by this Doctor:
Lymphoma, Melanoma, Sarcoma, Skin Cancer.

Clinical Appointments

  • Associate Consultant SingHealth Duke-NUS Blood Cancer Centre
  • Associate Consultant Division of Medical Oncology National Cancer Centre SingaporeNational Cancer Centre Singapore


Dr Jason Chan is currently an Associate Consultant at the Division of Medical Oncology, National Cancer Centre Singapore. He completed his medical oncology speciality training at the National Cancer Centre Singapore and has special interests in the treatment of soft tissue sarcomas and lymphomas. He is a member of the Singapore Society of Oncology (SSO), American Society of Clinical Oncology (ASCO), European Society of Medical Oncology (ESMO) and American Association for Cancer Research (AACR).

He is actively involved in graduate medical education and is a core faculty member of the Medical Oncology Senior Residency Program as well as clinical lecturer at the Yong Loo Lin School of Medicine, National University of Singapore.

His current research interests are on the molecular pathobiology of soft tissue sarcomas and lymphomas. He has contributed to published work on the molecular understanding of liposarcomas (JCO 2013) as well as breast fibroepithelial tumors (Nature Genetics 2015). Recently, he is exploring novel translational applications by studying the molecular pathogenesis of virus-associated soft tissue sarcomas and lymphomas.


  • MMED, Internal Medicine (Singapore) 2012 
  • MRCP (UK) 2012
  • MBBS National University of Singapore 2008 

Professional Appointments and Committee Memberships

  • Associate Consultant, Division of Medical Oncology, National Cancer Centre Singapore 2017 – Present Core 
  • Faculty Member, Medical Oncology Senior Residency Program 2017 – Present


  • SingHealth RiSE Outstanding Resident Award, 2017 
  • SingHealth Duke-NUS Research Day Appreciation Award - Bunsen Burner Award, 2017 
  • Nurturing Clinician Scientist Scheme, SingHealth Duke-NUS Academic Medical Centre, 2017
  • National University of Singapore Dean's Award for Teaching Excellence, 2016 
  • SingHealth RiSE Outstanding Resident Award, 2016 
  • Junior Pitch For Funds Award, SingHealth Internal Medicine Academic Clinical Program, 2014 
  • SingHealth RiSE Award for Outstanding Performance for In-Training/Intermediate Exams, 2013 
  • SingHealth Internal Medicine Residency Research Symposium Best Oral Presentation Award, 2013 
  • Frontiers in Cancer Science Conference Best Poster Award (co-author), 2009 
  • National Healthcare Group Annual Scientific Meeting Best Oral Presentation Award (Merit), 2009 
  • National Healthcare Group International Conference Award, 2009 
  • National University of Singapore Outstanding Undergraduate Researcher Prize, 2008 
  • National University of Singapore Outstanding Undergraduate Researcher Prize, 2007 
  • Jane Prize in Paediatrics, 2007
  • Elsevier Health Sciences Award, 2007

Publications and Research Trials

  • Elevated preoperative peripheral blood neutrophil-to-lymphocyte ratio to predict clinical outcome in patients with localized soft tissue sarcoma. Chan JY, Zewen Zhang, Winston Chew, Grace Fangmin Tan, Chloe Liwen Lim, Lingyue Zhou, Wei Lin Goh, Sathiyamoorthy Selvarajan, Kesavan Sittampalam, Francis Chin, Jonathan Teh, Mann Hong Tan, Khee Chee Soo, Melissa Teo , Mohamad Farid, Richard Quek. J Clin Oncol 35, 2017 (suppl; abstr 11049) 
  • Genomic landscapes of breast fibroepithelial tumors. Tan J, Ong CK, Lim WK, Ng C, Thike AA, Ng LM, Rajasegaran V, Myint SS, Nagarajan S, Thangaraju S, Dey S, Nasir ND, Wijaya GC, Lim JQ, Huang D, Li Z, Wong BW, Chan JY, McPherson JR, Cutcutache I, Poore G, Tay ST, Tan WJ, Putti TC, Ahmad BS, Iau P, Chan CW, Tang A, Yong WS, Madhukumar P, Ho GH, Tan VKM, Wong CY, Hartman M, Ong KW, Tan KT, Rozen SG, Tan P, Tan PT, Teh BT. Nature Genetics 2015 Nov;47(11):1341-5. 
  • Predictive molecular biomarkers to guide clinical decision making in kidney cancer: current progress and future challenges. Chan JY, Choudhury Y, Tan MH. Expert Review of Molecular Diagnostics 2015 May;15(5):631-46. 
  • Dedifferentiated liposarcoma with unusual Kaposiform morphology and whorl formation masquerading a Kaposi sarcoma: Diagnostically challenging case confirmed by cytogenetic and TP53 mutation analyses. Subramaniam MM, Chan JY, Leow PC, Venkateswaran K, Nathan S, Soong R, Kwok V. Journal of Clinical Oncology 2013 Mar 1;31(7):e101-5 
  • On Genetic Information Uncertainty and the Mutator Phenotype in Cancer. Chan JY. Biosystems Apr-Jun 2012; 108(1-3):28–33 
  • A Clinical Overview of Centrosome Amplification in Human Cancers. Chan JY. International Journal of Biological Sciences 2011 Oct; 7(8):1122-44 
  • Spontaneous and 5-fluorouracil-Evoked Centrosome Amplification Lowers Threshold to Resveratrol-Evoked Apoptosis in Colon Cancer Cells. Lee SC, Chan JY, Pervaiz S. Cancer Letters 2010 Feb; 288(1):36-41 
  • Molecular pathology of RUNX3 in human carcinogenesis. Subramaniam MM, Chan JY, Yeoh KG, Quek T, Ito K, Salto-Tellez M. BBA - Reviews on Cancer 2009 Dec;1796(2):315-31 
  • RUNX3 Inactivation in Colorectal Polyps Arising Through Different Pathways of Colonic Carcinogenesis. Subramaniam MM, Chan JY, Soong R, Ito K, Yeoh KG, Wong R, Guenther T, Will O, Chen CL, Kumarasingue MP, Ito Y, Salto-Tellez M. American Journal of Gastroenterology 2009 Feb;104(2):426-36 
  • Resveratrol Displays Converse Dose-Related Effects on 5-fluorouracil-Evoked Colon Cancer Cell Apoptosis: The Roles of Caspase-6 and p53. Chan JY, Phoo MS, Clement MV, Pervaiz S, Lee SC. Cancer Biology & Therapy 2008 Aug;7(8):1305-12

Research Trials