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Prof Lam Su Ping Carolyn

Prof Lam Su Ping Carolyn

​MBBS, PhD, MRCP, MS, FACC, FAMS, FESC

Senior Consultant

National Heart Centre Singapore

Specialty: Cardiology

Sub-specialties: Heart Failure

Conditions Treated by this Doctor:
Cardiovascular Disease, Heart Failure, Women’s Heart Disease.

Clinical Appointments

  • Senior Consultant Department of Cardiology National Heart Centre SingaporeNational Heart Centre Singapore
  • Director of Women’s Heart Health National Heart Centre SingaporeNational Heart Centre Singapore

Academic Appointments

  • Research EXCO SingHealth Duke-NUS Cardiovascular Sciences Academic Clinical Programme

Profile

Professor Carolyn Lam is a Senior Consultant from the Department of Cardiology and Director of Women's Heart Health at the National Heart Centre Singapore, having pioneered the first Women’s Heart Clinic in Singapore.  Academically, she serves as a tenured Full Professor at the Duke-National University of Singapore, having also graduated from the Standford Executive Programme in 2015, and obtained a PhD at the University Medical Centre Groningen, the Netherlands in 2016. In the field of MedTech, Prof Lam is co-founder of Us2.ai, an award-wining startup dedicated to the automation of the fight against heart disease by applying artificial intelligence to echocardiography (ultrasound of the heart).

Prof Lam is a world-renowned specialist in heart failure (particularly heart failure with preserved ejection fraction [HFpEF]). Her work in the PARAGON-HF and EMPEROR-Preserved trials led to the first FDA-approved treatment for HFpEF and the first robustly positive clinical outcomes trial in HFpEF to-date, respectively. She leads several multinational global and regional clinical trials, and has received numerous prestigious awards and global recognition for her work. Her recent appointments on the 2021 European Society of Cardiology Heart Failure Guidelines Task Force, and as International Honorary Fellow of the Heart Failure Society of America 2021, attest to her contributions in both cardiology and research fields.

Prof Lam is a proud recipient of the National Medical Research Council (NMRC) Senior Investigator Clinician Scientist Award in 2020, and served as the Founding Programme Lead of A*STaR’s Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT) and Principal Investigator of ASIAN-HF (a multinational study across 11 Asian countries). In 2019, She initiated the Asian Diabetes Outcomes Prevention Trial (ADOPT), an ongoing trial involving 5 countries and aimed at reducing the cardiovascular adverse outcomes of diabetes in Asian patients.

She has published with over 350 articles in major high impact journals including New England Journal of Medicine, Journal of the American Medical Association (JAMA), Lancet, Circulation, and European Heart Journal; and has been recognised as a World Expert by Expertscape’s PubMed-based algorithms (top 0.1% of scholars writing about Heart Failure over the past 10 years; Heart Failure: Worldwide - Expertscape.com). Besides being an Associate Editor for Circulation (top Cardiology Journal) and European Journal of Heart Failure, she is also the lead author of the chapter on HFpEF for Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine, 12th Edition - the award-winning textbook trusted by generations of cardiologists for the latest, most reliable guidance in the field.

Prof Lam serves as a consultant on several global advisory boards for cardiovascular disease, as a member of the Executive Committees of global heart failure trials, and as an Associate Editor for Circulation and the European Journal of Heart Failure. Finally, she is heard weekly on the global podcast "Circulation On The Run" and seen regularly on television as the Resident Doctor of the health programme "Body and Soul" by MediaCorp Singapore.

Education

  • Royal College of Physicians of Edinburgh Fellow of the Royal College of Physicians (FRCP), 2018​
  • University of Groningen, NLD PhD, 2016
  • Stanford Graduate School of Business, Stanford Executive Programme, 2015
  • Framingham Heart Study, MA, US, Fellowship (Clinical & Genetic Epidemiology), 2010
  • Mayo Clinic, Rochester MN, US, Master of Biomedical Science, 2009
  • Mayo Clinic, Rochester MN, US, Fellowship (Heart Failure & Advanced Cardiology), 2009
  • Ministry of Health, Singapore Specialist Accreditation (Cardiology), 2005
  • National University of Singapore, Bachelor of Medicine and Bachelor of Surgery (MBBS), 1998

Professional Appointments and Committee Memberships

Professional Appointments

  • 2022-23  Content Expert, Clinical Teacher and Clinical Practice Facilitator, Lee Kong Chian School of Medicine
  • 2021-present  Scientific Lead of Imaging – Echo and Theme Principal Investigator HFpEF and Women’s Health and Heart Muscle Disease, National Heart Research Institute Singapore (NHRIS)
  • 2020-present  Principal Lead of Clinical Trials & Trials Network, National Heart Research Institute Singapore (NHRIS)
  • 2020  Degree of Doctor Philosophiae causa, University of Oslo
  • 2019  SingHealth Investigational Medicine Unit Executive Committee, EXCO member
  • 2019  Adjunct Teaching Faculty Member, Lee Kong Chian School of Medicine
  • 2019  Conjoint Professor, University of New South Wales

Committee Memberships

  • 2021-2026  Member, National Clinical Trials Strategy Committee, Ministry of Health & National Medical Research Council
  • 2021-Present Scientific Expert, Global Data Collaborative for Cardiovascular Population Health, Microsoft and Novartis Foundation
  • 2021 European Society of Cardiology Heart Failure Guidelines Task Force
  • 2021 Co-Chair, Roadmap for Digital Health in Cardiology, World Heart Federation (WHF)
  • 2020-Present  Member, ESC Global Affairs Committee
  • 2018, 2020-2023  Full Member, Committee of the Education & Management Division on Clinical Applications of Cardiac Bio-Markers (C-CB) for International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)
  • 2019  Member, Global Health Programme Committee Group, European Society of Cardiology
  • 2019  Asia Pacific Representative, World Heart Federation Science Committee
  • 2019  Worldwide CardioDiabetes Board (Member), Worldwide Diabetes Foundation
  • 2019  NHLBI Atrial Fibrillation Working Group, NIH/NHLBI
  • 2016-2018  Local Review Panel Member, Clinician Scientist-Individual Research Grant, National Medical Research Council
  • 2018-2020  Member, Global Affairs Committee, European Society of Cardiology
  • 2018-2020  HFpEF Committee Member, Heart Failure Association, European Society of Cardiology
  • 2018  Member, Global Health Programme Committee Group, European Society of Cardiology
  • 2018  Co-Chair, International HF Working Group, American College of Cardiology (ACC)
  • 2017  Scientifc Advisor, Clinical Trials Coordinating Centre, SingHealth
  • 2017  Affiliate Member, SingHealth Duke-NUS Institute of Precision Medicine (PRISM)
  • 2017  Member, Lancet Commission on Cardiovascular Disease in Women
  • 2014, 2017  Clinician Scientist-Individual Research Grant (CS-IRG) Local Review Panel Member, National Medical Research Council Member
  • 2017  Member, International Federation of Clinical Chemistry & Laboratoy Medicine (IFCC) Task Force
  • 2016  HFpEF Committee Member, Heart Failure Association, European Society of Cardiology
  • 2016  Committee Member – Strategic Thrust #3 "Strenthen Collaborations", SingHealth Duke-NUS Research
  • 2015  Fellow, Academy of Medicine Singapore
  • 2015  Working Group for Heart Failure Outcomes, International Consortium for Health Outcomes Measurement
  • 2015  Writing Group, Consensus Document for the Diagnosis of HFpEF, Heart Failure Association, European Soceity of Cardiology
  • 2015  Workgroup, Clinical Practice Guidelines on Heart Failure, Ministry of Health
  • 2015  National Lead, European Atherosclerosis Society Familial Hypercholesterolemia Studies Collaboration
  • 2015  Member, Research Training Review Panel, Ministry of Health SAB Research Committee
  • 2014  Fellow, ASEAN Federation of Cardiology
  • 2014  Chairperson, Asia Pacific Association of Women's Cardiovascular Disease
  • 2013  Board Member, Singapore Heart Foundation
  • 2012  Member, Singapore Cardiac Society
  • 2012  Fellow, European Society of Cardiology
  • 2012  Fellow, American College of Cardiology
  • 2010  Faculty Member, Faculty of 1000 Medicine
  • 2001  Member, Royal College of Physicians

Awards

  • 2022 Experscape Expert in Obesity
  • 2021 Clarivate’s Highly Cited Researcher 2021 in the category of Clinical Medicine
    https://recognition.webofscience.com/awards/highly-cited/2021/
  • 2021 Recognized as a World Expert by Expertscape’s PubMed-based algorithms
    - Top 0.1% of scholars writing about Heart Failure over the past 10 years
    - Heart Failure: Worldwide - Expertscape.com
  • 2021 International Honorary Fellow of the Heart Failure Society of America 2021
  • 2020  Lee Foundation 2020 (ADOPT research) – Received S$2.28M - 'Arresting Heart Disease in Diabetics' under the Singhealth Duke NUS Cardiovascular Sciences Academic Clinical Programme
  • 2020  2nd prize for SingHealth Duke-NUS Research Team Award 2020 - "Asian neTwork for Translation Research and Cardiovascular Trials (ATTRaCT)"
  • 2019  Paul Dudley White International Scholar Award – To Recognize the Authors with the Highest Ranked Abstract from New Zealand at Scientific Sessions 2019    
  • 2019  National Medical Research Council Clinician Scientist Award (Senior Investigator Category) 
  • 2019  A*STAR Awards 2019: Borderless Award (awarded to ATTRaCT program; PI/ program director: Carolyn Lam SP)
  • 2019  GCEO – Outstanding Clinical Researcher Award
  • 2019  Bronte-Stewart Memorial Lectureship at the University of Glasgow
  • 2018  Singapore Health Quality Award 2018 – Outstanding & Commendable service for the period of April 2016 to March 2017, 2018
  • 2017  ESC Grants to attend Women Transforming Leadership Programme at Oxford University   
  • 2017  LEAP Award – EXCELLENCE (For 'Honours' Grade) for ACP Mentor
  • 2015  Rosalind Franklin Fellowship Award
  • 2014  Junior Chamber International (JCI) Ten Outstanding Young Persons of the World for 2014 Singapore Honouree Winner for Medical Innovation
  • 2013  National Medical Research Council Clinician Scientist Award (Senior Investigator category)
  • 2013  Singapore Women's Weekly Great Women Of Our Times (Winner)
  • 2012  L'Oreal Women In Science
  • 2012  InterAcademy Medical Panel Young Physician Leader (World Health Summit, Berlin)
  • 2012  Investigational Medicine Unit Bridging Fund Award
  • 2010  National Medical Research Council Clinician Scientist Award (Investigator category)
  • 2010  European Society of Cardiology Moderated Poster Award Winner
  • 2009  Evans Department of Medicine Research Days, Boston University School of Medicine, (3rd Prize for Clinical/Patient Based Research)
  • 2008  American Heart Association Women in Cardiology Trainee Award for Excellence
  • 2006  Jay N Cohn New Investigator Clinical/ Integrative Physiology Award Competition (First prize)
  • 2005  Liew Weng Chee Scholarship
  • 2004  China Medical Board Scholarship
  • 2004  Singapore Cardiac Society Young Investigator Award (First prize)
  • 2003  Society of Internal Medicine, San Diego (Finalist), 4th Annual International Poster Competition, American College of Physicians/ American
  • 2000  Society of Infectious Disease (Singapore) Award for the 7th Western Pacific Congress of Chemotherapy and Infectious Diseases
  • 1997-1998  Yeoh Khuan Joo Gold Medal (Surgery)
  • 1997-1998  Singapore Medical Association Bronze Medal
  • 1997-1998  Faculty of Medicine Dean's List Award
  • 1996-1997  Faculty of Medicine Dean's List Award 
  • 1995-1996  Medical Alumni Association Bronze Medal 
  • 1994-1996  Faculty of Medicine Dean's List Award 

Research Interests

  • Heart Failure
  • Clinical Trials
  • Echocardiography
  • Hemodynamics
  • Biomarkers
  • Sex Differences
  • Epidemiology

Publications

  • Jasper Tromp, Wouter Ouwerkerk, Tiew-Hwa K. Teng, John G. F. Cleland, Sahiddah Bamadha,  Christiane E. Angermann, Ulf Dahlstrom, Wan Ting Tay, Kenneth Dickstein, Georg Ertl, Mahmoud Hassanein, Sergio V. Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Sean P Collins, Gerasimos Filippatos, Carolyn SP Lam. Global Disparities in Prescription of Guideline-Recommended Drugs for Heart Failure with Reduced Ejection.  European Heart Journal.  Feb 2022.  JIF: 22.673
  • Carolyn SP Lam. How to incorporate sex and gender into the design of cardiovascular clinical trials. Circulation. 2022 Feb 15;145(7):499-501. doi: 10.1161/CIRCULATIONAHA.121.058771. JIF: 23.603
  • Subodh Verma, Nitish K Dhingra, Javed Butler, Stefan D Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L Januzzi, Carolyn SP Lam, Naveed Sattar, Barbara Peil, Matias Nordaby, Martina Brueckmann, Stuart JPocock, Faiez Zannad Milton Packer. Empagliflozin in the treatment of heart failure with reduced ejection fraction in addition to background therapies and therapeutic combinations (EMPEROR-Reduced): a post-hoc analysis of a randomised, double-blind trial. Lancet Diabetes & Endocrinology. 2021 Nov 30;S2213-8587(21)00292-8. doi: 10.1016/S2213-8587(21)00292-8. Online ahead of print. JIF: 25.340
  • Birgit Vogel, Monica Acevedo, Yolande Appelman, C Noel Bairey Merz, Alaide Chieffo, Gemma A Figtree, Mayra Guerrero, Vijay Kunadian, Carolyn SP Lam, Angela H E M Maas, Anastasia S Mihailidou, Agnieszka Olszanecka, Jeanne E Poole, Clara Saldarriaga, Jacqueline Saw, Liesl Zühlke, Roxana Mehran. The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030. The Lancet. 2021 Jun 19;397(10292):2385-2438. doi: 10.1016/S0140-6736(21)00684-X. Epub 2021 May 16. JIF: 60.392
  • Carolyn SP Lam, Chinthanie Ramasundarahettige, Kelley R.H. Bran ch,Naveed Sattar, Julio Rosenstock, Richard Pratley, Stefano Del Prato, Renato D. Lopes, Elisabeth Niemoeller, Nardev S. Khurmi, Seungjae Baek, Hertzel C. Gerstein. Efpeglenatide and Clinical Outcomes with and without Concomitant Sodium-Glucose Co-Transporter-2 Inhibition Use in Type 2 Diabetes: Exploratory Analysis of the AMPLITUDE-O Trial. Circulation. November 2021. JIF: 23.603
  • Carolyn SP Lam, João Pedro Ferreira, Egon Pfarr4, David Sim, Hiroyuki Tsutsui, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Stuart J. Pocock, Naveed Sattar, Subodh Verma, Martina Brueckmann, Janet Schnee, Daniel Cotton, Faiez Zannad, Milton Packer. Regional and Ethnic Influences on the Response to Empagliflozin in Patients With Heart Failure and a Reduced Ejection Fraction: the EMPEROR-Reduced trial. European Heart Journal. May 2021. JIF: 22.673
  • Carolyn SP Lam, Greg D Gamble, Lieng H Ling, David Sim, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P Ng, Vicky A Cameron, Katrina Poppe, Mayanna Lund, Gerry Devlin, Richard Troughton, A. Mark Richards*, Robert N Doughty *(*Co-senior authors); Mortality Associated With Heart Failure With Preserved Versus Reduced Ejection Fracton In A Prospective International Multi-Ethnic Cohort Study. European Heart Journal. 2018 May 21;39(20):1770-1780. doi: 10.1093/eurheartj/ehy005. JIF: 22.673
  • Subodh Verma, Nitish K. Dhingra, Javed Butler, Stefan D. Anker, Joao Pedro Ferreira, Gerasimos Filippatos, James L. Januzzi, Carolyn SP Lam, Naveed Sattar, Barbara Peil, Matias Nordaby, Martina Brueckmann, Stuart J. Pocock, Faiez Zannad, and Milton Packer for the EMPEROR-Reduced Trial Committees and Investigators. Efficacy and Safety of Empagliflozin According to Doses and Combinations of Other Treatments for Heart Failure: A Post Hoc Analysis of the EMPEROR-Reduced Randomized Trial. The Lancet Diabetes & Endocrinology. November 2021. JIF: 25.340
  • Jasper Tromp, Milton Packer, Carolyn SP Lam. The diverging role of epicardial adipose tissue in heart failure with reduced and preserved ejection fraction: not all fat is created equal. European Journal of Heart Failure. 2021 Oct 16. doi: 10.1002/ejhf.2363. JIF: 11.627
  • Carolyn SP Lam, Hillary Mulder, Yuri Lopatin, Jose B Vazquez-Tanus, David Siu, Justin Ezekowitz, Burkert Pieske, Christopher M O'Connor, Lothar Roessig, Mahesh J Patel, Kevin J Anstrom, Adrian F Hernandez, Paul W Armstrong, VICTORIA Study Group. Blood Pressure and Safety Events With Vericiguat in the VICTORIA Trial. Journal of the American Heart Association. 2021 Nov 6;e021094. doi: 10.1161/JAHA.121.021094. Epub 2021 Nov 6. JIF: 4.605
  • Jasper Tromp, Wouter Ouwerkerk, Dirk J. van Veldhuisen, Hans L. Hillege, A. Mark Richards, Peter van der Meer, Inder S. Anand, Carolyn SP Lam (co-corresponding author), Adriaan A. Voors. A Systematic Review and Network-Meta-Analysis of Pharmacological Treatment of Heart Failure with Reduced Ejection Fraction. JACC Heart Failure September 2021. JIF: 8.750
  • S.D. Anker, J. Butler, G. Filippatos, J.P. Ferreira, E. Bocchi, M. Böhm, H.-P. Brunner–La Rocca, D.-J. Choi, V. Chopra, E. Chuquiure-Valenzuela, N. Giannetti, J.E. Gomez-Mesa, S. Janssens, J.L. Januzzi, J.R. Gonzalez-Juanatey, B. Merkely, S.J. Nicholls, S.V. Perrone, I.L. Piña, P. Ponikowski, M. Senni, D. Sim, J. Spinar, I. Squire, S. Taddei, H. Tsutsui, S. Verma, D. Vinereanu, J. Zhang, P. Carson, Carolyn SP Lam, N. Marx, C. Zeller, N. Sattar, W. Jamal, S. Schnaidt, J.M. Schnee, M. Brueckmann, S.J. Pocock, F. Zannad, and M. Packer, for the EMPEROR-Preserved Trial Investigators. Empagliflozin in Heart Failure with a Preserved Ejection Fraction. The New England Journal of Medicine. August 2021. JIF: 74.699
  • Wan Ting Tay, Tiew-Hwa Katherine Teng, Oliver Simon, Wouter Ouwerkerk, Jasper Tromp, Robert N Doughty, Mark Richards, Chung-Lieh Hung, Yan Qin, Than Aung, Inder Anand, Carolyn SP Lam. Readmissions, death and its associated predictors in heart failure with preserved versus reduced ejection fraction. Journal of the American Heart Association. 2021 Nov 16;10(22):e021414. doi: 10.1161/JAHA.121.021414. Epub 2021 Oct 20. JIF: 4.605
  • Hertzel C. Gerstein, Naveed Sattar, Julio Rosenstock, Chinthanie Ramasundarahettige, Richard Pratley, Renato D. Lopes, Carolyn SP Lam, Nardev S. Khurmi, Laura Heenan, Stefano Del Prato, Leanne Dyal, Kelley Branch.  Efpeglenatide, Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes. June 2021.  New England Journal of Medicine. doi:10.1056/NEJMoa2108269 JIF: 74.699
  • Shih-Chieh Chien, Chanchal Chandramouli, Chi-In Lo, Chao-Feng Lin, Kuo-Tzu Sung, Wen-Hung Huang, Yau-Huei Lai, Chun-Ho Yun, Cheng-Huang Su, Hung-I Yeh, Ta-Chuan Hung, Chung-Lieh Hung, Carolyn SP Lam. Associations of obesity and malnutrition with cardiac remodelling and cardiovascular outcomes in Asian adults: A cohort study (Short title: Double burden of obesity and malnutrition on cardiac outcomes in Asians). PLOS Medicine. May 2021. JIF: 10.500
  • Carolyn SP Lam, Scott D. Solomon. Nomenclature in Heart Failure: Heart Failure with Reduced, Mildly Reduced and Normal Ejection Fraction. Journal of the American College of Cardiology. April 2021. JIF: 18.639
  • Martin Cowie and Carolyn SP Lam.  Remote monitoring and digital health tools in cardiovascular disease management.  Nature Reviews Cardiology. 6 April 2021. https://doi.org/10.1038/s41569-021-00548-x. JIF: 20.260
  • Jasper Tromp, Jennifer A. Bryant, Xuanyi Jin, Gijs van Woerden, Salma Asali, Han Yiying, Oi Wah Liew, Jenny Chong Pek Ching, Fazlur Jaufeerally, Seet Yoong Loh, David Sim, Sheldon Lee, Dinna Soon, Wan Ting Tay, Milton Packer, Dirk J. van Veldhuisen, Calvin Chin, A Mark Richards, Carolyn SP Lam. Epicardial fat in heart failure with reduced versus preserved ejection fraction.  European Journal of Heart Failure. 16 March 2021. doi:10.1002/ejhf.2156. JIF: 11.627
  • Carolyn SP Lam, Robert Wood, Muthiah Vaduganathan, Hector Bueno, Alex Chin, Gabriela Luporini Saraiva, Elisabeth Sörstadius, Theo Tritton, Joseph Thomas, Lei Qin. Contemporary economic burden in a real-world heart failure population with Commercial and Medicare Supplemental Plans. Clinical Cardiology. 11 March 2021. https://doi.org/10.1002/clc.23585 JIF: 2.248  
  • Carolyn SP Lam, Avraham Karasik, Cheli Melzer-Cohen,,Matthew A. Cavender, Shun Kohsaka, Anna Norhammar, Marcus Thuresson, Hungta Chen, Eric Wittbrodt, Peter Fenici, Mikhail Kosiborod on behalf of the CVD-REAL Investigators and Study Group. Association of SGLT2 inhibitors with outcomes in Type 2 diabetes with reduced and preserved left ventricular ejection fraction — Analysis from the CVD-REAL 2 Study. Diabetes, Obesity and Metabolism. February 2021. https://doi.org/10.1111/dom.14356 JIF: 5.9
  • Jasper Tromp, Brian L. Claggett, Jiankang Liu, Alice M. Jackson, Pardeep S. Jhund, Lars Kober, Jiri Widimsky, Sergey Boytsov, Vijay Chopra, Inder S. Anand, Junbo Ge, Chen-Huan Chen, Aldo P. Maggioni, Felipe Martinez, Milton Packer, Marc A. Pfeffer, Burkert Pieske, Margaret M. Redfield, Jean L. Rouleau, Dirk J. Van Veldhuisen, Faiez Zannad, Michael R. Zile, Adel R. Rizkala, Akiko Inubushi-Molessa, Martin P. Lefkowitz, Victor C. Shi, John J.V. McMurray, Scott D. Solomon, Carolyn SP Lam on behalf of the PARAGON-HF Investigator.  Global Differences in Heart Failure in Preserved Ejection Fraction: the PARAGON-HF trial.  Circulation: Heart Failure. February 2021. JIF: 5.420
  • Jasper Tromp*, Samantha M.A. Paniagua*, Emily S. Lau, Norrina B. Allen, Michael J. Blaha, Ron Gansevoort, Hans Hillege, Douglas E. Lee, Daniel Levy, Vasan S. Ramachandran, Pim van der Harst, Wiek van Gilst, Martin G. Larson, Sanjiv J. Shah*, Rudolf A. de Boer*, Carolyn SP Lam*#, Jennifer E. Ho*#.  Age-dependent Associations of Risk Factors with Heart Failure.  British Medical Journal February 2021. JIF: 30.223 *these authors contributed equally #co-last author
  • THK Teng, WT Tay, AM Richards, TSM Chew, I Anand, W Ouwerkerk, C Chandramouli, W Huang, C Lawson, UT Kadam, J Yap, SL Lim, C-L Hung, MR MacDonald, SY Loh, W Shimizu, J Tromp, Carolyn SP Lam. Socioeconomic status and outcomes in heart failure with reduced ejection fraction from Asia. Circulation: Cardiovascular Quality and Outcomes. 24 March 2021. doi: 10.1161/CIRCOUTCOMES.120.006962. JIF: 5.07
  • Chorh Chuan Tan, Carolyn SP Lam, David B. Matchar, Yoong Kang Zee, John E.L. Wong.  Singapore’s Healthcare System: Key features, Challenges and Shifts.  The Lancet. 2021 Sep 18;398(10305):1091-1104. doi: 10.1016/S0140-6736(21)00252-X. Epub 2021 Sep 2. JIF: 60.392
  • Kanako Teramoto, Jasper Tromp, Carolyn SP Lam.  Heart Failure or Heart Success? Cardiovascular Research Onlife. https://doi.org/10.1093/cvr/cvab022 13 February 2021.  JIF: 8.68
  • Janice Y Chyou, Wan Ting Tay, Inder S Anand, Tiew-Hwa Katherine Teng, Jonathan JL Yap, Michael R MacDonald, Vijay Chopra, Seet Yoong Loh, Wataru Shimizu, Imran Zainal Abidin, ASIAN-HF Investigators, A Mark Richards, Javed Butler, Carolyn SP Lam. Electroanatomic Ratios and Mortality in Patients with Heart Failure: Insights from the Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF) Registry. J Am Heart Assoc January 2021 JIF: 4.66
  • Carolyn SP Lam, Adriaan A. Voors, Piotr Ponikowski, John J.V. McMurray, Scott D. Solomon. Time to rename the Middle Child of Heart Failure: Heart Failure with Mildly Reduced Ejection Fraction.  European Heart Journal 2020 Jul 1;41(25):2353-2355. doi: 10.1093/eurheartj/ehaa158. JIF: 22.637
  • Carolyn SP Lam, Anna Giczewska, Karen Sliwa, Frank Edelmann, Jens Refsgaard, Edimar Bocchi, Justin A. Ezekowitz, Adrian F. Hernandez, Christopher M. O’Connor, Lothar Roessig, Mahesh J. Patel, Burkert Pieske, Kevin J. Anstrom, Paul W. Armstrong, on behalf of the VICTORIA Study Group. Clinical Outcomes and Response to Vericiguat According to Index Heart Failure Event: Insights from the VICTORIA Trial. JAMA Cardiol. 2021 Jun 1;6(6):706-712. doi: 10.1001/jamacardio.2020.6455. JIF: 12.794
  • Sanjiv Shah, Sandra Sanders-van Wijk, Jasper Tromp, Lauren Beussink-Nelson, Camilla Hage, Sara Svedlun, Antti Saraste, Stanley Swat, Cynthia Sanchez, Joyce Njoroge, Ru-San tan, Maria Fermer, L-Ming Gan, Lars Lund, Carolyn SP Lam. Proteomic Evaluation of the Comorbidity-Inflammation Paradigm in Heart Failure with Preserved Ejection Fraction: Results from the PROMIS-HFpEF Study. Circulation. October 2020. https://doi.org/10.1161/CIRCULATIONAHA.120.045810 JIF: 23.603
  • Paul W Armstrong, Carolyn SP Lam, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Christopher M O'Connor, Burkert Pieske, Piotr Ponikowski, Sanjiv J Shah, Scott D Solomon, Adriaan A Voors, Lilin She, Vanja Vlajnic, Francine Carvalho, Luke Bamber, Robert O Blaustein, Lothar Roessig, Javed Butler on behalf of the 9 VITALITY-HFpEF Study Group. Effect of Vericiguat versus Placebo on Quality of Life in Patients with Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial. JAMA. 2020. JIF: 45.540
  • Weiting Huang, Tiew-Hwa Katherine Teng, Wan Ting Tay, A, Mark Richards, Claire A. Lawson, Inder Anand, Carolyn SP Lam. Patient-Reported Outcomes in Heart Failure with Preserved versus Reduced Ejection Fraction: Focus on Physical Independence. ESC Heart Failure. 2020 Aug 30. doi: 10.1002/ehf2.12950. JIF: 3.902
  • Shun Kohsaka, Carolyn SP Lam, Dae Jung Kim, Matthew A Cavender, Anna Norhammar, Marit E Jørgensen, Kare I Birkeland, Reinhard W Holl, Josep Franch-Nadal, Navdeep Tangri, Jonathan E Shaw, Jenni Ilomäki, Avraham Karasik, Su-Yen Goh, Chern-En Chiang, Marcus Thuresson, Hungta Chen, Eric Wittbrodt, John Bodegård, Filip Surmont, Peter Fenici, Mikhail Kosiborod, CVD-REAL 2 Investigators and Study Group. Risk of cardiovascular events and death associated with initiation of SGLT2 inhibitors compared with DPP-4 inhibitors: an analysis from the CVD-REAL 2 multinational cohort study. Lancet Diabetes Endocrinol. 2020 Jul;8(7):606-615. doi: 10.1016/S2213-8587(20)30130-3. JIF: 25.340
  • Paul W Armstrong, Burkert Pieske, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Javed Butler, Carolyn SP Lam, Piotr Ponikowski, Adriaan A Voors, Gang Jia, Steven E McNulty, Mahesh J Patel, Lotar Roessig, Joerg Koglin, Christopher M O'Connor, VICTORIA Study Group. Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. New England Journal of Medicine. 2020 May 14;382(20):1883-1893. Epub 2020 Mar 28. doi: 10.1056/NEJMoa1915928. JIF: 74.699
  • Jasper Tromp, Sahiddah Bamadhaj, John G F Cleland, Christiane E Angermann, Ulf Dahlstrom, Wouter Ouwerkerk, Wan Ting Tay, Kenneth Dickstein, George Ertl, Mahmoud Hassanein, Sergio V Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Carolyn SP Lam, Gerasimos Filippatos, Sean P Collins. Post-discharge prognosis of patients admitted to hospital for heart failure by world region, and national level of income and income disparity (REPORT-HF): a cohort study. Lancet Global Health. 2020 Mar;8(3):e411-e422. doi: 10.1016/S2214-109X(20)30004-8. JIF: 21.597
  • Jennifer E. Ho; Margaret M. Redfield; Gregory D. Lewis; Walter J. Paulus; Carolyn SP Lam. Deliberating the Diagnostic Dilemma of HFpEF. Circulation. 2020. JIF: 23.603
  • Sana AI-Khatib, Emelia Benjamin, Christine M Albert, Alvaro Alonso, Cynthia Chauhan, Peng-Sheng Chen, Anne B Curtis, Patrice Desvigne-Nickens, Jennifer E Ho, Carolyn SP Lam, Mark S Link, Kristen K Patton, Margaret M Redfield, Michiel Rienstra, Yves Rosenberg, Renate Schnabel, John A Spertus, Lynne Warner Stevenson, Mellanie True Hills, Adriaan A Voors, Lawton S Cooper, Alan S Go. Advancing Research on the Complex Interrelations between Atrial fibrillation and Heart Failure: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop. URL: https://circ-submit.aha-journals.org. Circulation. 2020 Jun 9;141(23):1915-1926. doi:10.1161/CIRCULATIONAHA.119.045204. JIF: 23.603
  • Gillian Stein, Tiew-Hwa K Teng, Wan T Tay, A Mark Richards, Robert Doughty, YanHong Dong, David Sim, Poh S D Yeo, Fazlur Jaufeerally, Gerard Leong, Dinna Soon, Lieng H Ling, Carolyn SP Lam. Ethnic Differences in Quality of Life and its Association with Survival in Patients with Heart Failure. Clinical Cardiology. 2020 Sep;43(9);976-985. doi:10.1002/clc.23394. Epub 2020 Jun 20. JIF: 2.248
  • Stefan D Anker, Javed Butler, Muhammad Shahzeb Khan, William T Abraham, Johann Bauersachs, Edimar Bocchi, Biykem Bozkurt, Eugene Braunwald, Vijay K Chopra, John G Cleland, Justin Ezekowitz, Gerasimos Filippatos, Tim Friede, Adrian F Hernandez, Carolyn SP Lam, JoAnn Lindenfeld, John J V McMurray, Mandeep Mehra, Marco Metra, Milton Packer, Burkert Pieske, Stuart J Pocock, Piotr Ponikowski, Giuseppe M C Rosano, John R Teerlink, Hiroyuki Tsutsui, Dirk J Van Veldhuisen, Subodh Verma, Adriaan A Voors, Janet Wittes, Faiez Zannad, Jian Zhang, Petar Seferovic, Andrew J S Coats. Conducting Clinical Trials in Heart Failure During (and After) the COVID-19 Pandemic: An Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). European Heart Journal. 2020 Jun 7;41(22):2109-2117. doi: 10/1093/eurheartj/egaa461. JIF: 22.673
  • Wouter Ouwerkerk, Tiew-Hwa K Teng, Jasper Tromp, Wan Ting Tay, John G Cleland, Dirk J van Veldhuisen, Kenneth Dickstein, Leong L Ng, Chim C Lang, Stefan D Anker, Faiez Zannad, Chung-Lieh Hung, Jitendra P S Sawhney, Ajay Naik, Wataru Shimizu, Nobuhisa Hagiwara, Gurpreet Singh Wander, Inder Anand, A Mark Richards, Adriaan A Voors, Carolyn SP Lam. Effects of combined renin-angiotensin-aldsterone system inhibitor and beta-blocker treatment on outcomes in heart failure with reduced ejection fraction: insights from BIOSTAT-CHF and ASIAN-HF registries. European Journal of Heart Failure. 2020 Jun 25. doi: 10.1002/ejhf.1869. JIF: 11.627
  • Wouter Ouwerkerk, Jasper Tromp, Xuanyi Jin, Fazlur Jaufeerally, Poh Shuan Daniel Yeo, Kui Toh Gerard Leong, Hean Yee Ong, Lieng Hsi Ling, Seet Yoong Loh, David Sim, Sheldon Lee, Dinna Soon, Calvin Chin, A. Mark Richards, and Carolyn SP Lam. Heart failure with preserved ejection fraction diagnostic scores in an Asian population. doi:10.1002/ejhf.1851. European Journal of Heart Failure. 2020 May 6. doi: 10.1002/ejhf.1851. JIF: 11.627
  • Wouter Ouwerkerk, Jasper Tromp, Xuanyi Jin, Fazlur Jaufeerally, Poh Shuan Daniel Yeo, Kui Toh Gerard Leong, Hean Yee Ong, Lieng Hsi Ling, Seet Yoong Loh, David Sim, Sheldon Lee, Dinna Soon, Calvin Chin, A. Mark Richards, Carolyn SP Lam. HFpEF diagnostic scores in an Asian population. European Journal of Heart Failure. 2020. JIF: 11.627
  • Shun Kohsaka, Carolyn SP Lam, Dae Jung Kim, Matthew A Cavender, Anna Norhammar, Marit E Jørgensen, Kåre I Birkeland, Reinhard W Holl, Josep Franch-Nadal, Navdeep Tangri, Jonathan E Shaw, Jenni Ilomäki, Avraham Karasik, Su-Yen Goh, Chern-En Chiang, Marcus Thuresson, Hungta Chen, Eric Wittbrodt, Johan Bodegård, Filip Surmont, Peter Fenici, Mikhail Kosiborod on behalf of the CVD-REAL Investigators and Study Group. Lower Risk of Cardiovascular Events and Death Associated with Initiation of SGLT-2 Inhibitors in Comparison with DPP-4 Inhibitors – Analysis from CVD-REAL 2, an observational, comparative effectiveness international, collaborative cohort study. The Lancet Diabetes & Endocrinology. 2020. JIF: 25.340
  • Paul W Armstrong,  Burkert Pieske, Kvin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Javed Butler, Carolyn SP Lam, Piotr Ponikowski, Adriaan A Voors, Gang Jia, Steven E McNulty, Mahesh J Patel, Lothar Roessig, Joerg Koglin, Christopher M O'Connor, VICTORIA Study Group. Vericiguat in Patients with Heart Failure with Reduced Ejection Fraction. New England Journal of Medicine. 2020 May 14;382(20);1883-1893. doi: 10.1056/NEJMoa1915928. Epub 2020 Mar 28. JIF: 74.699
  • Eugene SJ Tan, Vera Goh, Bernadet T. Santema, Wan Ting Taye, Tiew-Hwa Katherine, Jonathan Yap, Jasper Tromp, Chung-Lieh Hung, Vijay Chopra, Inder Anand, Michael R. MacDonald, Lieng Hsi Ling, Isabelle C. Van Gelder, Michiel Rienstra, Adriaan A. Voors, A. Mark Richards, Carolyn SP Lam. Ethnic differences in atrial fibrillation among patients with heart failure in Asia. ESC Heart Failure. 2020 Aug;7(4);1419-1429. doi: 10.1002/ehf2.12696. Epub 2020 May 8. JIF: 3.902
  • Carolyn SP Lam, Adriaan A Voors, Ponikowski Piotr, John J V McMurray, Scott D Solomon. Time to rename the Middle Child of Heart Failure: Heart Failure with Mildly Reduced Ejection Fraction. European Heart Journal. 2020 Jul 1;41(25)2353-2355. doi: 10.1093/eurheartj/ehaa158.  JIF: 22.673
  • Justina Motiejūnaitė, Eiichi Akiyama, Alain Cohen-Solal, Aldo Pietro Maggioni, Christian Muellerh, Dong-Ju Choi, Aušra Kavoliūnienė, Jelena Čelutkienė, Jiri Parenica, Johan Lassus, Katsuya Kajimoto, Naoki Sato, Òscar Miró, W. Frank Peacock, Yuya Matsue, Adrian Voors, Carolyn SP Lam, Justin A. Ezekowitz, Ali Ahmed, Greg C. Fonarowv, Etienne Gayat, Vera Regitz-Zagrosek and Alexandre Mebazaa, on behalf of the GREAT (Global Research on Acute Conditions Team) Network. Gender-related Differences in Long-term outcome in Patients with Acute Heart Failure from different geographic regions. European Heart Journal. 2020. JIF: 22.637
  • Shijun Xia, Xin Du, Lizhu Guo, Jing Du, Clare Arnott, Carolyn SP Lam, Mark D Huffman, Hisatomi Arima, Yiqiang Yuan, Yang Zheng, Shulin Wu, Xuefeng Guang, Xianhui Zhou, Hongbo Lin, Xiaoshu Cheng, Craig S Anderson, Jianzeng Dong, Changsheng Ma. Sex differences in primary and secondary prevention of cardiovascular disease in China. Circulation. 2020 Feb 18;141(7);530-539. doi: 10.1161/CIRCULATIONAHA.119.043731. Epub 2020 Feb 17. JIF: 23.603
  • Milton Packer, Carolyn SP Lam, Lars H. Lund, Margaret M. Redfield. Interdependence of Atrial Fibrillation and Heart Failure with a Preserved Ejection Fraction Reflects a Common Underlying Atrial and Ventricular Myopathy. Circulation. 2020 Jan 7:141:4-6. doi:10.1161/CIRCULATIONAHA.119.042996. Epub 2019 Dec 30. JIF: 23.603
  • Gerasimos Filippatos, Christiane E Angermann, John G F Cleland, Carolyn SP Lam, Ulf Dahlstrom, Kenneth Dickstein, Gero Ertl, Magmoud Hassanein, Kimberly W Hart,  Christopher J Lindsell, Sergio V Perrone, Tadhg Guerin, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Sean P Collins. Global Differences in Characteristics, Precipitants and Initial Management of Patients Presenting with Acute Heart Failure. JAMA Cardiology. 2020 Apr 1;5(4);401-410. doi: 10.1001/jamacardio.2019.5108. JIF: 21.597
  • Xurui Jin, Chanchal Chandramouli, Brooke Allocco, Enying Gong, Carolyn SP Lam, Lijing L Yan. Women's Participation in Cardiovascular Clinical Trials from 2010 to 2017. Circulation. 2020 Feb 18;141(7):540-548. doi: 10.1161/CIRCULATIONAHA.119.043594. Epub 2020 Feb 17. JIF: 23.603
  • John V McMurray, Alice M Jackson, Carolyn SP Lam, Margaret M Redfield, Inder S Anand, Junbo Ge, Martin P Lefkowitz, Aldo P Maggioni, Felipe Martinez, Milton Packer, Marc A Pfeffer, Burkert Pieske, Adel R Rizkala, Shalini V Sabrarwal, Amil M Shah, Sanjiv V Shah, Victor C Shi, Dirk J Veldhuisen, Faiez Zannad, Michael R Zile, Maja Cikes, Eva Goncalvesova, Tzvetana Katova, Annamaria Kosztin, Malgorzata Lelonek, Nancy Sweitzer, Orly Vardeny, Brian Claggett, Pardeep S Jhund, Scott D Solomon. Effects of sacubitril-valsartan, versus valsartian, in women compared to men with heart failure and preserved ejection fraction: Insights from PARAGON-HF. Circulation. 2020 Feb 4;141(5):338-351. doi: 10:1161/CIRCULATIONAHA.119.044491. Epub 2019 Oct 12. JIF: 23.603
  • Carolyn SP Lam, Chanchal Chandramouli, Vineeta Ahooja, Subodh Verma. SGLT-2 Inhibitors in Heart Failure: Current Management, Unmet Needs, and Therapeutic Prospects. Journal of the American Heart Association. 2019 Oct 15:8(20):e013389. doi: 10.1161/JAHA.119.013389. Epub 2019 Oct 12. JIF: 4.45
  • Tiew-Hwa Katherine Teng, Lauren Cooper, Wan Ting Tay, Nancy Luo, Abhinav Sharma, David Whellan, Inder Anand, Ileana L. Pina, Jasper Tromp, A Mark Richards, William Kraus, Christopher M O' Connor, Robert J Mentz, Carolyn SP Lam. Association between body surface area and prescribed doses of guideline-directed medications among international patients with heart failure and reduced ejection fraction. European Journal of Heart Failure. 2020 Apr;22(4);754-758. doi: 10.1002/ejhf.1648. Epub 2019 Dec 18. JIF: 11.627
  • Scott D Solomon, John J V McMurray, Inder S Anand, Junbo Ge, Carolyn SP Lam, Aldo P Maggioni, Felipe Martinez, Milton Packer, Marc A. Pfeffer, Burkert Pieske, Margaret M Redfield, , Jean L Rouleau, Dirk J van Veldhuisen, Faiez Zannad, Michael R Zile, Akshay S Desai, Brian Claggett, Pardeep S Jhund, Sergey A Boytsov, Josep Comin-Colet, John Cleland, Hans-Dirk Duengen, Eva Goncalvesova, Tzvetana Katova, Jose F Kerr Saraiva, Małgorzata Lelonek, Bela Merkely, Michele Senni, Sanjiv J Shah, Jingmin Zhou, Adel R Rizkala, Jianjian Gong, Victor C Shi, Martin P Lefkowitz. PARAGON-HF Investigators and Committees. Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. The New England Journal of Medicine. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655. Epub 2019 Sep 1. JIF: 74.699
  • Degang Wu, Jinzhuang Dou, Xiaoran Chai, Claire Bellis, Andreas Wilm, Chih Chuan Shih, Wendy Wei Jia Soon, Nicolas Bertin, Clarabelle Bitong Lin, Chiea Chuen Khor, Michael DeGiorgio, , Shanshan Cheng, Li Bao, Neerja Karnani, Sonia Davila, Patrick Tan, Asim Shabbir, Angela Moh, Eng-King Tan, Jia Nee Foo, Liuh Ling Goh, Khai Pang Leong, Roger S.Y. Foo, Carolyn SP Lam, Arthur Mark Richards, Ching-Yu Cheng, Tin Aung, Tien Yin Wong, Huck Hui Ng, Jianjun Liu, and Chaolong Wang. Large-scale whole-genome sequencing of three diverse Asian populations in Singapore. Cell. 2019 Oct 17;179(3):736-749.e15. doi: 10.1016/j.cell.2019.09.019. JIF: 38.637
  • Jasper Tromp, Camilla Hage, Wouter Ouwerkerk, Sandra Sanders-van Wijk, Sara Svedlund, Antti Saraste, Ulrika Ljung Faxén, Maria Lagerstrom Fermer, Li-ming Gan, Lars H Lund, Sanjiv J Shah, Carolyn SP Lam. Biomarker Correlates of Coronary Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction. Circulation. 2019 Oct 15; 140(16):1359-1361. doi: 10.1161/CIRCULATIONAHA.119.042569. Epub 2019 Oct 14. JIF: 23.603
  • Jonathan Yap, Wan Ting Tay, Tiew-Hwa Katherine Teng, Inder Anand, A Mark Richards, Lieng Hsi Ling, Michael R MacDonald, Chanchal Chandramouli, Jasper Tromp, Bambang B Siswanto, Michael Zile, John McMurray, Carolyn SP Lam. Association of Diabetes on Cardiac Remodelling, Quality of Life and Clinical Outcomes in Heart Failure with Reduced and Preserved Ejection Fraction. Journal of the American Heart Association. 2019 Sep 3;8(17):e013114. Doi: 10.1161/JAHA.119.013114. Epub 2019 Aug 21. JIF: 4.45
  • Bernadet T Santema, Wouter Ouwerkerk, Jasper Tromp, Iziah E Sama, Alice Ravera, Vera Regitz-Zagrosek, Hans Hillege, Nilesh J Samani, Faiez Zannad, Kenneth Dickstein, Chim C Lang, John G Cleland, Jozine M Ter Maaten, Marco Metra, Stefan D Anker, Pim van der Harst, Prof. Leong L Ng, Peter van der Meer, Dirk J van Veldhuisen, Sven Meyer, Carolyn SP Lam, ASIAN-HF investigators, Adriaan A Voors. Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational cohort study. Lancet. 2019 Oct 5;394(10205);1254-1263. doi: 10.1016/S0140-6736(19)31792-1. Epub 2019 Aug 22. JIF: 60.392
  • Mandeep R Mehra, Muthiah Vaduganathan, Min Fu, João Pedro Ferreira, Stefan D Anker, John GF Cleland, Carolyn SP Lam, Dirk J van Veldhuisen, William M Byra, Theodore E Spiro, Hsiaowei Deng, Faiez Zannad, Barry Greenberg. A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial. European Heart Journal. 2019 Nov 21;40(44):3593-3602. doi:10.1093/eutheartj/ehz427. JIF: 22.673
  • Jasper Tromp, Shir Lynn Lim, Wan Ting Tay, Tiew-Hwa Katherine Teng, Chanchal Chandramouli, WouterOuwerkerk, Gupreet SWander, Jitendra PS Sawhney, JonathanYap, Michael R MacDonald, Lieng His Ling, Naveed Sattar, John JV McMurray, A Mark Richards, InderAnand, Carolyn SP Lam, ASIAN-HF investigators. Microvascular disease in patients with Diabetes with heart failure and reduced ejection versus preserved ejection fraction. Diabetes Care. 2019 Sep;42(9):1792-1799. doi: 10/2337/dc18-2515. Epub 2019 July 10. JIF: 15.3
  • Eugene S J Tan, Wan Ting Tay, Tiew-Hwa Katherine Teng, David Sim, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze Pin Ng, Katrina Poppe, Mayanna Lund, Gerard Devlin, Richard Troughton, Lieng Hsi Ling, Arthur Mark Richards, Robert N Doughty, Carolyn SP Lam. Ethnic Differences in Atrial Fibrillation in Patients with Heart Failure from Asia-Pacific Heart. Heart. 2019 Jun; 105 (11): 842-847. doi: 10.1136/heartjnl-2018-314977. Epub 2019 Jan 19. JIF: 5.420
  • Yvonne May Fen Chia, Tiew-Hwa K Teng, Wan T Tay, Inder Anand, Michael R MacDonald, Jonathan Yap, Chanchal Chandramouli, A Mark Richards, Jasper Tromp, Wouter Ouwerkerk, Lieng Hsi Ling, Carolyn SP Lam, ASIAN-HF investigators. Prescription patterns of anti-diabetic medications and clinical outcomes in Asian patients with heart failure and diabetes mellitus. European Journal of Heart Failure. 2019 May;21(5):685-688. doi: 10.1002/ejhf.1467. Epub 2019 Apr 29. JIF: 11.627
  • Jonathan Yap, Shaw Yang Chia, Fang Yi Lim, John C Allen, Louis Teo, David Sim, Yun Yun Go, Fazlur Rehma Jaufeerally, Mattew Seow, Bernard Kwok, Reginald Liew, Carolyn SP Lam. The Singapore Heart Failure Risk Score: Prediction of survival in Southeast Asian patients hospitalised with heart failure. ANNALS of the Academy of Medicine Singapore. 2019 Mar;48(3):86-94. JIF:  1.533
  • Jasper Tromp, Michael R MacDonald, Wan Ting Tay, Tiew-Hwa K. Teng, Chung-Lieh Hung, Calambur Narasimhan, Wataru Shimizu, Ling Hsi Ling, Tze Pin Ng, Jonathan Yap, John J V McMurray, Michael R Zile, A Mark Richards, Inder S Anand, Carolyn SP Lam. Heart Failure with Preserved Ejection Fraction in the Young. Circulation. 2018 Dec 11;138(24):2763-2773. doi.10.1161/CIRCULATIONAHA.118.034720. JIF: 23.603
  • Yun Yun Go, Reinhard Sellmair, John C Allen Jr, Anders Sahlén, Heerajnarain Bulluck, David Sim, Fazlur R Jaufeerally, Michael R MacDonald, Zhan Yun Lim, Ping Chai, Seet Yoong Loh, Jonathan Yap, Carolyn SP Lam. Defining a 'frequent admitter' phenotype among patients with repeat heart failure admissions. European Journal of Heart Failure. 2019 Mar;21(3):311-318. doi: 10.1002/ejhf.1348. Epub 2018 Dec 13. JIF: 11.627
  • Jasper Tromp, Tiew-Hwa Teng, Wan Ting Tay, Chung Lieh Hung, Calambur Narasimhan, Wataru Shimizu, Sang Weon Park, Houng Bang Liew, Tachapong Ngarmukos, Eugene B Reyes, Bambang Siswanto, Checuk-Man Yu, Shu Zhang, Jonathan Yap, Michael MacDonald, Lieng Hsi Ling, Kirsten Leineweber, A Mark Richards, Michael R Zile, Inder S Anand, Carolyn SP Lam, ASIAN-HF Investigators. Heart Failure with Preserved Ejection Fraction in Asia. European Journal of Heart Failure. 2019 Jan;21(1):23-36. doi: 10.1002/ejhf.1227. Epub 2018 Aug 16. JIF: 11.627
  • Bernadet T Santema, Mariëlle Kloosterman, Isabelle C Van Gelder, Ify Mordi, Chim C Lang, Carolyn SP Lam, Stefan D Anker, John G Cleland, Kenneth Dickstein, Gerasimos Filippatos, Pim van der Harst, Hans L Hillege, Jozine M Ter Maaten, Marco Metra, Leong L Ng, Piotr Ponikowski, Nilesh J Samani, Dirk J Van Veldhuisen, Aeilko H Zwinderman, Faiez Zannad, Kevin Damman, Peter van der Meer, Michiel Rienstra, Adriaan A Voors. Comparing biomarker profiles of patients with heart failure: atrial fibrillation vs. sinus rhythm and reduced versus preserved ejection fraction. European Heart Journal. 2018 Nov 14;39(43):3867-3875. doi: 10.1093/eurheartj/ehy421. JIF: 22.673
  • Faiez Zannad, Stefan D Anker, William M Byra, John G F Cleland, Min Fu, Mihai Gheorghiade, Carolyn SP Lam, Mandeep R Mehra, James D Neaton, Christopher C Nessel, Theodore E Spiro, Dirk J van Veldhuisen, Barry Greenberg, COMMANDER HF Investigators. Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease. New England Journal of Medicine. 2018 Oct 4;379(14):1332-1342. doi: 10.1056/NEJMoa1808848. Epub 2018 Aug 27. JIF: 74.699
  • Carolyn SP Lam, Wolfram Doehner, Josep Comin-Colet, IRON CORE Group. Iron deficiency in chronic heart failure: Case-based practical guidance. ESC Heart Failure. 2018 Oct;5(5):764-771. doi: 10.1002/ehf2.12333. Epub 2018 Aug 2. JIF: 3.902
  • Sanjiv J Shah, Carolyn SP Lam, Sara Svedlund, Antti Saraste, Camilla Hage, Ru-San Tan, Lauren Beussink-Nelson, Maria Lagerstrom Fermer, Malin A Broberg, Li-Ming Gan, Lars H Lund. Prevalence and Correlates of Coronary Microvascular Dysfunction in Heart Failure with Preserved Ejection Fraction: PROMIS-HFpEF.  European Heart Journal. 2018 Oct 1;39(37):3439-3450. doi: 10.1093/eurheartj/ehy531. JIF: 22.673
  • Lauren B Cooper, Jonathan Yap, Wan Ting Tay, Tiew-Hwa K Teng, Michael MacDonald, Inder S Anand, Abhinav Sharma, Christopher M O'Connor, William E Kraus, Robert J Mentz, Carolyn SP Lam, HF-ACTION and ASIAN-HF investigators. Multi-Ethnic Comparisons of Diabetes in Heart Failure with Reduced Ejection Fraction: Insights from the HF-ACTION Trial and the ASIAN-HF Registry. European Journal of Heart Failure. 2018 Sep;20(9):1281-1289. doi: 10.1002/ejhf.1223. Epub 2018 Jun 26. JIF: 11.627
  • Tiew-Hwa K Teng, Jasper Tromp, Wan Ting Tay, Inder Anand, Wouter Ouwerkerk, Vijay Chopra, Gurpreet S Wander, Jonathan Jl Yap, Michael R MacDonald, Chang Fen Xu, Yvonne Mf Chia, Wataru Shimizu, ASIAN-HF investigators, A Mark Richards, Adriaan Voors, Carolyn SP Lam. Prescribing patterns of evidence-based heart failure pharmacotherapy and outcomes in the ASIAN-HF registry: a cohort study. Lancet Global Health. 2018 Sep;6(9):e1008-e1018. doi:10.1016/S2214-109X(18)30306-1. JIF: 21.597
  • Jiun-Lu Lin, Kuo-Tzu Sung, Cheng-Huang Su, Tzu-Hsun Chou, Chi-In Lo, Jui-Peng Tsai, Shun-Chuan Chang, Yau-Huei Lai, Kuang-Chun Hu, Chia-Yuan Liu, Chun-Ho Yun, Chung-Lieh Hung, Hung-I Yeh, MD, Carolyn SP Lam. Cardiac Structural Remodeling, Longitudinal Systolic Strain and Torsional Mechanics in Lean and Non-lean Dysglycemic Chinese Adults. Circulation: Cardiovascular Imaging. 2018 May;11(5):e007047. doi: 10.1161/CIRCIMAGING.117.007047. JIF 4.780
  • Vera J Goh, Jasper Tromp, Tiew-Hwa K. Teng, Wan Ting Tay, Peter Van Der Meer, Lieng Hsi Ling, Bambang B Siswanto, Chung-Lieh Hung, Wataru Shimizu, Shu Zhang, Calambur Narasimhan, Cheuk Man Yu, Sang Weon Park, Tachapong Ngarmukos, Houng Bang Liew, Eugenio Reyes, Jonathan Yap, Michael Macdonald, A Mark Richards, Inder Anand, Carolyn SP Lam. Prevalence, clinical correlates and outcomes of anaemia in multiethnic Asian patients with heart failure with reduced ejection fraction. ESC Heart Failure. 2018 Aug;5(4)570-578. doi: 10.1002/ehf2.12279. Epub 2018 Mar 31. JIF: 3.902
  • Carolyn SP Lam, Greg D Gamble, Lieng H Ling, David Sim, Kui Toh Gerard Leong, Poh Shuan Daniel Yeo, Hean Yee Ong, Fazlur Jaufeerally, Tze P Ng, Vicky A Cameron, Katrina Poppe, Mayanna Lund, Gerry Devlin, Richard Troughton, A Mark Richards*, Robert N Doughty *(*Co-senior authors). Mortality Associated with Heart Failure with Preserved Versus Reduced Ejection Fracton In A Prospective International Multi-Ethnic Cohort Study. European Heart Journal. 2018 May 21;39(20):1770-1780. doi: 10.1093/eurheartj/ehy005. JIF: 22.673
  • Tee Joo Yeo, Poh Shuan Daniel Yeo, Farid Abdul Hadi, Timothy Cushway, Kim Yee Lee, Fang Fang Yin, Anne Ching, Ruili Li, Seet Yoong Loh, Shir Lynn Lim, Raymond Ching-Chiew Wong, Bee Choo Tai, Arthur Mark Richards, Carolyn SP Lam. Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF). ESC Heart Failure. 2018 Apr;5(2):344-353. doi: 10.1002/ehf2.12250. Epub 2018 Jan 18. JIF: 3.902
  • Yun Yun Go, Tadafumi Sugimoto, Heerajnarain Bulluck, Sanchalika Acharyya, John Carson Allen, Shaw Yang Chia, Fazlur Rehman Jauferally, David Sim, Tiong Keng Lim, Reginald Liew, Carolyn SP Lam. Age and ejection fraction modify the impact of atrial fibrillation on acute heart failure outcomes. European Journal of Heart Failure. 2018 Apr;20(4):821-822. doi: 10.1002/ejhf.1075. Epub 2017 Nov 16. JIF: 11.627
  • Jasper Tromp, Wan Ting Tay, Wouter Ouwerkerk, Tiew-Hwa Katherine Teng, Jonathan Yap, Michael R MacDonald, Kirsten Leineweber, John J V McMurray, Michael R Zile, Inder S Anand, Carolyn S P Lam, ASIAN-HF authors. Multimorbidity in patients with heart failure from 11 Asian regions: A prospective cohort study using the ASIAN-HF registry. PLOS Medicine. 2018 March 27;15(3):e1002541. doi: 10.1371/journal.pmed.1002541. eCollection 2018 Mar. JIF: 10.500
  • Thomas M Gorter, Joost P van Melle, Michiel Rienstra, Barry A Borlaug, Yoran M Hummel, Isabelle C van Gelder, Elke S Hoendermis Adriaan A Voors, Dirk J van Veldhuisen, Carolyn SP Lam. Right Heart Dysfunction in Heart Failure with Preserved Ejection Fraction: The Impact of Atrial Fibrillation. Journal of Cardiac Failure. 2018 Mar;24(3):177-185. doi: 10.1016/j-cardfail.2017.11.005. Epub 2017 Nov 29. JIF: 3.942.
  • Jasper Tromp, A Mark Richards, Wan Ting Tay, Tiew-Hwa K Teng, Poh Suan, Daniel Yeo, David Sim, Fazlur Jaufeerally, Gerard Leong, Hean Yee Ong, Lieng Hsi Ling, Dirk J van Veldhuisen, Tiny Jaarsma, Adriaan A Voors, Peter van der Meer, Rudolf de Boer*, Carolyn SP Lam* (*corresponding author). NT-proBNP and Prognosis in Caucasian versus Asian Patients with Heart Failure. Short title: Ethnicity and NT-proBNP in Heart Failure. ESC Heart Failure. 2017. JIF: 3.902
  • Chung-Lieh Hung, Szu-Hua Pan, Chia-Li Han, Ching-Wei Chang, Yuan-Ling Hsu, Cheng-Huang Su, Shou-Chuan Shih, Yu-Jun Lai,  Jen-Shiu Chiang Chiau, Hung-I Yeh, Chia-Yuan Liu, Hung-chang Lee, Carolyn SP Lam. Membrane Proteomics of Impaired Energetics and Cytoskeletal Disorganization in Elderly Diet-Induced Diabetic Mice. Journal of Proteome Research. 2017 Oct 6;16(10):3504-3513. doi: 10.1021/acs.jprotemome.7b00148. Epub 2017 Sep 13. JIF: 4.268
  • Carolyn SP Lam, Karen Barry, Amit Khera. Medical Podcasting and Circulation On the Run: Why, How and What Now. Circulation. 2017 Aug 8;136(6):513-515. doi: 10.1161/CIRCULATIONAHA.117.029760. JIF: 23.603
  • Yau-Huei Lai, Ming-En Liu, Cheng-Huang Su, Chun-Ho Yun, Chia-Yuan Liu, Charles Jia-Yin Hou, Kuang-Chun Hu, Chung-Lieh Hung, Hung-I Yeh, Carolyn SP Lam. Obesity-Related Changes In Cardiac Structure And Function Among Asian Men And Women. Journal of the American College of Cardiology. 2017 Jun 13;69(23)2876-2878. doi: 10.1016/j.jacc.2017.04.016. JIF: 18.639
  • Chih-Hsuan Yen, Kuang-Te Wang, Ping-Ying Lee, Chuan-Chuan Liu, Ya-Ching Hsieh, Jen-Yuan Kuo, Bernard E. Bulwer, Chung-Lieh Hung, Shun-Chuan Chang, Shou-Chuan Shih, Kuang-Chun Hu, Hung-I Yeh, Carolyn SP Lam. Gender-Differences in the Associations between Circulating Creatine Kinase, Blood Pressure, Body Mass and Non-Alcoholic Fatty Liver Disease in Asymptomatic Asians. PLOS ONE. 2017 Jun 30;12(6):e0179898. doi: 10.1371/journal.pone.0179898. eCollection 2017. JIF: 2.740
  • Carolyn SP Lam, Scott D Solomon. Fussing Over The Middle Child: Heart Failure With Mid-Range Ejection Fraction. Circulation. 2017 Apr 4;135(14):1279-1280. doi: 10.1161/CIRCULATIONAHA.117.027324. JIF: 23.603
  • Burkert Pieske, Aldo Maggioni, Carolyn SP Lam, Elisabeth Pieske-Kraigher, Gerasimos Filippatos, Javed Butler, Piotr Ponikowski, Sanjiv J. Shah, Scott D. Solomon, Andrea-Viviana Scalise, Katharina Mueller, Lothar Roessig, Mihai Gheorghiade. Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study. European Heart Journal. 2017 Apr 14;38(15):1119-1127. doi: 10.1093/eurheartj/ehw593. JIF: 22.673
  • Carolyn SP Lam, Michiel Rienstra, Wan Ting Tay, Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rudolf A de Boer, Isabelle C Van Gelder, Dirk J van Veldhuisen, , Adriaan A Voors, Elke S Hoendermis. Atrial Fibrillation in Heart Failure with Preserved Ejection Fraction: Association with Exercise Capacity, Left Ventricular Filling Pressures, Natriuretic Peptides, and Left Atrial Volume. JACC Heart Failure. 2017 Feb;5(2);92-98. doi: 10.1016/j.jchf.2016.10.005. Epub 2016 Dec 21. JIF: 8.750
  • Carolyn SP Lam, Tiew-Hwa Katherine Teng, Wan Ting Tay, Inder Anand, Shu Zhang, Wataru Shimizu, Calambur Narasimhan, Sang Weon Park, Cheuk-Man Yu, Tachapong Ngarmukos, Razali Omar, Eugene B Reyes, Bambang B Siswanto, Chung-Lieh Hung, Lieng H Ling, Jonathan Yap, Michael MacDonald, A Mark Richards. Regional and ethnic differences among patients with heart failure in Asia: the asian sudden cardiac death in heart failure registry. European Heart Journal. 2016 Nov 1; 37(41):3141-3153. doi: 10.1093/eurheartj/ehw331. Epub 2016 Aug 7. JIF: 22.673
  • Lijing L Yan, Heng Jiang, Carolyn SP Lam. Random Plasma Glucose Levels and Cardiovascular Risk. JAMA Cardiology. 2016 Oct 1;1(7):823-824. doi: 10.1001/jamacardio.2016.1802. JIF: 12.794
  • Crystel M Gijsberts, Lina Benson, Ulf Dahlström, David Sim, Daniel P S Yeo, Hean Yee Ong, Fazlur Jaufeerally, Gerard K T Leong, Lieng H Ling, A Mark Richards, Dominique P V de Klejin, Lars H Lund, Carolyn SP Lam. Ethnic differences in the association of QRS duration with ejection fraction and outcome in heart failure. Heart. 2016 Sep 15;102(18);1462-71. doi: 10.1136/heartjnl-2015-309212. Epub 2016 Jul 11. JIF: 5.420
  • Jonathan Yap, Ai Zhen Jin, Shwe Zin Nyunt, Tze Pin Ng, A Mark Richards, Carolyn SP Lam. Longitudinal Community-Based Study of QT Interval and Mortality in Southeast Asians. PLoS One. 2016 May 5;11(5) e0154901. doi: 10.1371/journal.pone.0154901. eCollection 2016. JIF: 2.740
  • Carolyn SP Lam, Lars H Lund. Microvascular endothelial dysfunction in heart failure with preserved ejection fraction. Heart. 2016 Feb 15; 102(4):257-9. doi: 10.1136/heartjnl-2015-308852. JIF: 5.420
  • Michelle M Y Chan, Rajalakshmi Santhanakrishnan, Jenny PC Chong, Zhaojin Chen, Bee Choo Tai, Oi Wah Liew, Tze Pin Ng, Lieng H Ling, David Sim, Kui Toh G Leong, Poh Shuan Daniel Yeo, Hean-Yee Ong, Fazlur Jaufeerally, Raymond Ching-Chiew Wong, Chai Ping, Adrian F Low, Arthur Mark Richards, Carolyn SP Lam. Growth Differentiation Factor 15 in Heart Failure with Preserved versus Reduced Ejection Fraction. European Journal of Heart Failure. 2016 Jan; 18(1):81-8. JIF: 11.627

Research Trials

  • 2022   Baseline and repeat NT-proBNP in patients with Heart Failure
  • 2021  Arresting Heart Disease in Diabetics, SingHealth Duke NUS Cardiovascular Sciences Academic Clinical Programme
  • 2020-2024  Asian Diabetes Outcomes Prevention Trial (ADOPT), NMRC CTG-ICT
  • 2019-2023  Cardiovascular Clinical Trials in Asia: Asian Diabetes Outcomes Prevention Trial (ADOPT), NMRC Clinician Scientist Award
  • 2019-2023  Cardiovascular Clinical Trials in Asia: Asian Diabetes Outcomes Prevention Trial (ADOPT), Roche Diagnostics
  • 2019-2023  Early Phase Experimental Cardiovascular Trial Unit, Bayer
  • 2017-2018  eKo.ai, A*Star
  • 2017-2018  Asian Sudden Cardiac Death in Heart Failure 2 (ASIAN-HF2 study), Bayer
  • 2015-2018  Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF study), Bayer
  • 2015-2017  Asian Diabetes Outcomes Registry (ADORE)
  • 2015  Metabolomic Profiling In Heart Failure With Preserved Vs Reduced Ejection Fraction
  • 2015-2017  Coronary Flow Reserve in Heart Failure with Preserved Ejection Fraction (CFR-HFpEF)
  • 2015-pre  Programme Lead of the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), A*Star BMRC
  • 2014-2019  NMRC Clinician Scientist Award: Clinical Trials in Heart Failure
  • 2014-2017  Toll-like receptor 2 as a therapeutic target in heart failure
  • 2014-2016  Randomised, controlled pilot study to assess the role of IV ferric carboxymaltose in Asian patients with HF
  • 2014-2019  REnal SymPathECTomy in Heart Failure (RESPECT-HF) Study
  • 2014  Electrocardiographic Parameters in Asian Versus Western Adults
  • 2013-2018  Theme 1 of National Medical Research Council Centre Grant
  • 2013  A randomized, double-blind, crossover study to assess the effects of LCZ696 and valsartan in Asian patients with salt-sensitive hypertension
  • 2011-2016  Asian Sudden Cardiac Death in Heart Failure (ASIAN-HF study), Boston Scientific
  • 2010-2012  Outcome in Patients with Heart Failure with a Preserved Left Ventricular Ejection Fraction (the “PEOPLE” study)
  • 2010-2013  Prospective compArison of ARNI with ARB on Management Of heart failUre with preserved ejectioN fraction “PARAMOUNT”, Novartis
  • 2009-2012  Biomarkers and Management of Cardiovascular Disease: Singapore, Heart Failure Outcomes and Phenotypes (the “SHOP” study)