You are invited to the upcoming event by Dr Ying Gu, Principal Investigator, Deputy Director of BGI – Research, Beijing Genomics Institute.
Title: Understanding Biology through Spatiotemporal Omics
Abstract:
The current progresses of single-cell sequencing and spatiotemporal transcriptome enable scientists not only can discover the specific cell types in tissue, but also can detect the cell distribution in the spatial dimension. Taking advantages of a newly developed spatial-temporal transcriptomics approach—SpaTial Enhanced REsolution Omics-sequencing (Stereo-seq) by BGI-research, with the highest profiling resolution to data, we studied the cellular and molecular dynamics during organ regeneration process in Axolotl, an animal that can regenerate damaged appendages and multiple internal organs, including the brain. Employing Stereo-seq, we generated a group of spatial transcriptomic data of telencephalon sections that covered six developmental and seven injury-induced regenerative stages. We discovered a sub-population of progenitor cells may then proliferate to cover the wound area and subsequently replenish lost neurons. Interestingly, we also observed that regeneration of the axolotl telencephalon exhibited similar neurogenesis patterns to development, suggesting that brain regeneration partially recapitulates the development process. Our spatial transcriptomic data highlights the cellular and molecular features of the axolotl telecephalon during development and injury-induced regeneration.
Seminar Details:
Date: 13 March 2024 (Wednesday)
Time: 2:30pm – 3:30pm
Venue:
Amphitheatre, Level 2, Duke-NUS
Host:
Asst Prof Alfred Sun
Principal Investigator
Neuroscience & Behavioural Disorders Programme
Duke-NUS
All are welcome. No registration is required.
