You are invited to attend this seminar hosted by the Institute of Molecular and Cell Biology:
Date: Wednesday, 8 May 2024
Time: 11.00AM – 12.00PM
Venue: IMCB Seminar Room 03-46, Level 3 Proteos, Biopolis, Singapore 138673 (Physical)
Speaker: Prof Raphael Scharfmann, INSERM
Host: Dr Adrian Teo, IMCB
Pancreatic Endocrine Cell Development from Rodent to Human; A Business Trip
Abstract
I will discuss innovative assays that we developed and used during the past 25 years to dissect the regulation of functional pancreatic beta cell (the cells that produce and secrete insulin) mass, both in rodent and human. Specifically, I will focus on (i) assays based on the culture of fetal pancreases, to study beta cell development in rodent; (ii) assays based on transplantation and FACS to dissect pancreas development in human; (iii) assays to dissect the role of alpha cells (the cells that produce glucagon) in beta cell function; and (iv) innovative approaches to generate functional human beta cell lines and their study in patho-physiological conditions.
Biography
Raphael Scharfmann obtained his PhD in 1989 at University Paris VII, France. He next did a post doc at the Salk institute, La Jolla, CA (1989-1991) and obtained a permanent position at INSERM at the end of 1991. He obtained the prestigious Minkowski Award (for distinguished research in the field of Diabetes in Europe) (1999) and the Bettencourt Award (2012). He is currently Research Director at INSERM within the Cochin Institute, University Paris-Cité, France. He is one of the co-founders of EndoCells/Human Cell Design, a French biotech company. The major objective of his group is to develop innovative ways define signals regulating functional pancreatic endocrine cell mass in rodent and human.
ALL ARE WELCOME (No registration required).
