PRINCIPAL INVESTIGATOR/
LABORATORY |
INTERNATIONAL COLLABORATORS |
RESEARCH CENTRE |
PROJECT TITLE |
PROF HUI KAM MAN
Bek Chai Heah Laboratory of Cancer Genomics |
Prof H Kim Lyerly |
Duke Comprehensive Cancer Centre, USA |
Hepatocellular Carcinoma |
| Prof Walter Gunzburg |
Research Institute of Virology and Biomedicine, University of Veterinary Medicine; Vienna, Austria |
| Prof Farzin Farzaneh |
The Rayne Institute, King’s College, UK |
Gene therapy of cancer |
| |
DR PAULA LAM
Laboratory of Cancer Gene Therapy |
Prof Xandra Breakefield |
Harvard Medical School, Massachusetts General Hospital-East, USA |
Generation and characterization of chimeric viral vectors gene therapy for pre-clinical studies. |
| A/Prof Fraefel C |
University of Zurich, Switzerland |
Characterization of pYEBac102 recombinants |
| Prof Abhijit Guha |
University of Toronto, Hospital for Sick Children |
Towards a better understanding of human gliomas |
| Dr Bakhos A Tannous |
Harvard Medical School, Massachusetts General Hospital-East, USA |
|
PROF MALCOLM PATERSON
Laboratory of Genome Maintenance
|
Dr Sibghat-Ullah Lari |
Department of Biological and Medical Research, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia |
Initiation of strand incision at a G:T mismatch in model DNA by human cells: Characterization of a novel ATP-dependent pathway |
| Dr Futwan A Al-Mohanna |
Triggering the calcium transient by non-ionizing (far UV) radiation |
| Dr Razmik Mirzayans |
Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada |
Characterization of the prostaglandin E2-activated signaling pathway mediating the correction of RDS in ataxia telangiectasia fibroblasts |
| Dr Brian J Druker |
Oregon Cancer Institute, Oregon Health Sciences University, Portland, Oregon, USA |
Phosphoproteomic Identification of human tumor signalling susbtrates in vitro and in vivo: comparison
with quiescent cells and normal tissues |
| Dr A Price |
Department of Oncology, University of Edinburgh, UK |
Radiobiological accuracy & uncertainty |
| Dr NACS Wong |
| Dr H Monahan |
Department of Pathology, University of Edinburgh, UK |
| Dr DJ Harrison |
|
A/PROF HUYNH THE HUNG
Laboratory of Molecular Endocrinology |
Dr Samuel Freedman |
Lady Davis Institute for Medical Research, McGill University, Canada |
Hormonal aspect of breast cancer |
| Dr Michael Pollak |
Breast Cancer Prevention Centre, McGill University, Canada |
Anti-estrogens in breast cancer treatment and preventation |
| Dr Gerald Batist |
Translational Research Centre, McGill University, Canada |
Chemo-preventation of breast and liver cancers |
| Dr Laurence Panasci |
Department of Medicine, McGill University, Canada |
Uses of SarCNU in the treatment of Hepatocellular Carcinoma |
| Dr Mostafa Elhilali |
McGill University, Canada |
IGF systems in bladder hypertrophy and bladder cancer |
| Dr Van Tan |
Binh Dan Hospital, Viet Nam |
Hepatitis B and C infection and liver cancer in Vietnam |
| Dr Khin Maung Win |
Yangon General Hospital, Myanmar |
Insulin-like growth factor binding prolteins in HCC |
|
A/PROF PATRICK TAN
Laboratory of Molecular Genomics |
Dr Phillippe Broet |
University of Paris |
Genomics of Lung Cancer |
| Dr Sophie Camilleri-Broët |
| Dr Heike Grabsch |
University of Leeds, UK |
Molecular Genomics of Upper GI Cancers |
| |
A/PROF KANAGA SABAPATHY
Laboratory of Molecular Carcinogenesis |
Dr Roger Reddel |
Children’s Hospital Research Centre, Melbourne, Australia |
Effects of telomerase on the longetivity and senescence of mouse primary cells |
| Dr Maria Sibilia |
University of Vienna, Austria |
Regulation of differentiation and embryonic development by p53 |
| Dr Erwin Wagner |
Institute of Molecular Pathology, Vienna, Austria |
Role of p53 in ES cell differentiation |
| Role of JNKs in development, growth and apoptosis |
| Dr Yoichi Taya |
National Cancer Centre, Tokyo, Japan |
Analysis of phosphorylation status of p53 and its effects on p53 regulation |
| Dr Saturo Kyo |
Dept. of Obstetrics, University of Kobe, Japan |
Telomerase promoter regulated tumor therapy |
| Dr Axel Behrens |
University of Zurich, Switzerland & Imperial cancer Research Fund, UK |
Function of phosphorylation of c-Jun in T lymphocyte development and tumorigenesis |
| Dr Massimo Broggini |
University of Milan, Italy |
Studies on p53/p73 |
| Prof Alex Pintzas |
National Helenia Research Foundation, Athens, Greece |
Role of c-Jun/JNK in cellular signalling |
| Prof Robert Silverman |
Case Western Reserve University, Cleaveland, Ohio, USA |
Roles of JNK-induced apoptosis |
| Prof Stanley Cohen |
Stanford University, USA |
Identification of upstream activators of p53 |
| Dr Isabella Graef |
Beckmann Centre, Stanford University, USA |
Role of NF-AT in JNK mediated fucntions in T cells |
| Dr Moshe Yaniv |
Pasteur Institute, France |
Role of JNKs in regulation of p53/mdm2 & cell migration |
| Dr Jonathan Weitzman |
| Dr Fukunaga Rikiro |
Osaka University, Japan |
Genetic screen to identify JNK targets |
| Dr Karen Vousden |
Beatson Institute, Glasgow, UK |
Regulation of p73 |
| Dr Luzia Fischer |
Polish Academy of Sciences |
Role of p53 polymorphism in Caucasian population |
| Dr Rene Bernards |
Dutch Cancerer Institute (NKI) |
Role of DUBs in rgualtion of p73 and cJun stability |
| Dr Zhao Qi Wang |
IARC, Lyon, France |
Mouse models for p53 & human cancer |
|
DR GANESAN GOPALAN
Laboratory of Gene Structure
& Expression |
Dr Peter J Donovan |
University of California, Irvine, USA |
Generation of Aurora-A knockout mice |
| |
A/PROF KON OI LIAN
Laboratory of Applied Human Genetics |
Sir Roy Calne |
Cambridge University, UK |
Gene- & cell-based treatment of diabetes |
| Dr Tai-Tung Yip |
Ciphergen Biosystems Inc., USA |
Protein profiling of gastric fluid |
| Dr Sun Young Rha |
Yonsei Cancer Center, Seoul, Korea |
Spectral karyotyping of gastric cancer cells |
| Dr Fan Hong & Dr Guo Qiang |
The First People’s Hospital of Yunnan, China |
Gastric fluid cytology and protein profiling |
| Crusade Laboratories |
Glasgow, Scotland, UK |
Gene therapy vectors |
| Poetic Genetics, Inc. |
Burlingame, California, USA |
Site-specific recombination system |
|
PROF SOO KHEE CHEE & A/PROF MALINI OLIVO
Tan Chin Tuan Laboratory of Optical Imaging & Photodynamic Therapy |
Prof Martin Harris |
Melbourne University / Optiscan |
Endomicroscopy using fluorescent markers & 2-Photon Endoscopy |
| Prof Qian Peng |
Dept of Pathology, The Norwegian Radium Hospital, University of Oslo, Montebello, 0310 Oslo, Norway |
Photobiology |
| Prof Baumgartner |
Physicist, Laser Forschungslabor, Urologische Klinik der LMU, Marchioninistr. 23, D-81377
Munich, FRG |
Biophotonics instrumentation in cancer diagnosis |
| Prof Tayabba Hasan |
Wellman Labs of PhotoMedicine, Harvard Medical School, USA |
Photomedicine |
| Dr Manfred Haupt |
Haemato Science GmbH, Biotechnologiepark, 14943 Luckenwalde Germany |
Fotolon (chlorin e6) as a pharmaceutical agent |
| Prof Britton Chance |
University of Pennsylvania |
Biophotonics instrumentation in cancer diagnosis |
| Prof Steven Bown |
University College Hospital, London, UK & Ark Therapeutics, UK Plc |
Photodynamic therapy |
| Prof Sune Svanberg |
University of Lund, Sweden |
Biophotonics instrumentation in cancer diagnosis |
| Dr Othmar Dill |
Serapeutics, Germany |
PDT and Immunology |
| Prof Khin Maung Win |
Dept of Heptology, Yangon General Hospital, Myanmar |
AHCC01 |
| Prof Phillip Johnson |
Dept of Clinical Oncology, Chinese University of Hong Kong |
| A/Prof Thomas Leung |
| Dr Tjakra Wibawa Manuaba |
Dept of Surgery, School of Medicine, University
of Undayana, Bali, Indonesia |
| Dr Thiravud Khuhaprema |
National Cancer Institute, Bangkok, Thailand |
| Prof Haron Ahmad |
Dept of Surgery, University Kebangsaan
Malaysia, Kuala Lumpur, Malaysia |
| A/Prof Michael Findlay |
Wellington Regional Oncology Unit, Wellington |
| Dr Si-Hyun Bae |
St Vincent’s Hospital, Catholic University of Korea, South Korea |
| A/Prof Johnathan Cebon |
Austin and Repatriation Medical Centre, Melbourne, Australia |
|
A/PROF ANN LEE
Laboratory of Molecular Oncology |
Prof Joe Gray |
University of California, San Francisco, USA |
Array CGH analysis of Cancer |
| A/Prof Els Robanus-Maandag |
Centre for Human & Clinical Genetics, Leiden University Medical Centre (LUMC) |
| Prof Calvin Pang |
Dept of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong |
Mutational spectrum of BRCA 1 and BRCA2 genes in breast cancer |
| Dr Christina Rudduck-Sivaswaren |
Children’s Hospital at Westmead, Sydney |
FISH and array CGH analysis of cancer |
| Dr Nick Paton |
Clinical Trials Unit, Medical Research Council, UK |
Molecular analysis of Mycobacterium tuberculosis |
|
A/PROF CAROLINE LEE
Laboratory of Liver Cancer Functional Genomics |
Dr Kuan-Teh Jeang |
National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA |
Functional Genomics of HCC |
| Dr Linda Lee |
Johns Hopkins University School of Medicine, USA |
| Dr Michael Gottesman |
National Cancer Institute, National Institutes of Health, USA |
Genetics of ABC transporters |
| |
A/PROF LONDON LUCIEN OOI
Laboratory of Liver Cancer Functional Genomics |
Dr Llew Keltner |
LightSciences Corporation, USA |
LSC-OL004 - A phase 1/2 open-label study to evaluate safety and prelimninary evidence of LED in the treatment of subjects with inoperable HCC |
| Dr Jay Winship |
| Dr James Chen |
A Phase 3 Randomized Study to Evaluate Survival
of Patients Treated with Talaporfin Sodium (LS11)
and Interstitial Light Emitting Diodes (LED) as
Compared to the Standard of Care Therapies in
the Treatment of Unresectable Hepatocellular
Carcinoma (HCC) |
| Dr Sy-Shi Wang |
|
| Dr Stephen Barker |
University College Hospital, London, UK & Ark Therapeutics, UK Plc |
Trial on EO-impregnated wound dressings |
|
DR MAC HO MENG FATT
Laboratory of Oncoproteomics |
Dr Robert H Brown Jr |
Massachusetts General Hospital-East, Harvard Medical School, USA |
Proteomic Analysis of Dysferlinopathy |
| Dr Gregory A Cox |
The Jackson Laboratory, USA |
| Dr Hart GW Lidov |
Children’s Hospital, Harvard Medical School, USA |
| Prof Anthony P Monaco |
The Wellcome Trust Centre, Oxford, UK |
Neuroacanthocytosis syndromes |
| Dr Soohee Lee |
New York Blood Center, NY, USA |
| Dr Colvin Redman |
| Dr Adrian Danek |
Munich, Germany |
| Dr Heike Grabsch |
Leeds University, UK |
Proteomic Approaches for Biomarker Discovery in
Gastric Cancer |
| |
DR BALRAM CHOWBAY
Laboratory of Clinical Pharmacology |
Dr Alex Sparreboom |
National Institutes of Health, USA |
Pharmacokinetics & pharmacogenetics in cancer Laboratory of Clinical
therapy |
| Dr Howard McLeod |
Washington University in St Louis School of Medicine, USA |
Pharmacogenetics in cancer patients |
| Dr Etienne Chatelut |
Institute Claudius Regaud, France |
Pharmacokinetics |
| Dr Zhou Shufeng |
Queensland Univ of Technology |
Pharmacokinetics & pharmacogenetics in cancer
therapy |
|
DR JOSEPH WEE
Head, Division of Clinical Trials & Epidemiological Sciences |
Dr Winnie Yeo |
Dept of Clinical Oncology, Chinese University of Hong Kong |
A Phase I /II study of PXD101 in patients with unresectable hepatocellular carcinoma with pharmacokinetic and pharmacodynamic evaluation |
| Dr Anthony Chan |
| Dr Alex Chang |
Johns Hopkins Singapore Int Med Centre |
| Dr Tony Mok |
Dept of Clinical Oncology, Chinese University of Hong Kong |
| Dr Benny Zee |
| Dr Hyun Cheol Chung |
Division of Haematology-Oncology, Yonsei Cancer
Centre, Yonsei University College of Medicine. |
| Dr Pun Hui |
Dept of Clinical Oncology, Chinese University of
Hong Kong |
| Dr Lisa Horvath |
Sydney Cancer Centre, Royal Prince Alfred Hospital |
| Dr Hei Cheul Jeung |
Yonsei Metastasis Research, Yonsei Cancer Centre |
| Dr Brigette Ma |
Dept of Clinical Oncology, Chinese University of
Hong Kong |
| Dr Michael Millward |
School of Medicine and Pharmacology,
University of Western Australia, Sir Charles
Gairdner Hospital |
| Dr Michael Boyer |
Sydney Cancer Centre, Royal Prince Alfred Hospital |
| Dr Sun Young Rha |
Division of Haematology-Oncology, Yonsei Cancer
Centre, Yonsei University College of Medicine |
| Dr Jae Kjung Roh |
Division of Haematology-Oncology, Yonsei Cancer Centre, Yonsei University
College of Medicine |
| Dr Qian Tao |
Cancer Epigenetics Lab, Dept of Clinical Oncology, Chinese University Of Hong Kong |
| Dr Simon Chung Ho Yu |
Dept of Diagnostic Radiology and Organ
Imaging, Chinese University of Hong Kong |
| Dr Ka-Fai To |
Dept of Anatomical and Cellular Pathology, Chinese University of Hong Kong |
| Dr Brigette Ma |
Dept of Clinical Oncology, Chinese University of Hong Kong |
A phase II study of triapine and gemcitabine as second-line treatment of advanced non-small cell lung cancer in patients who had prior gemcitabine with evaluation of the effect of triapine on gemcitabine pharmacokinetics and cellular uptake in peripheral mononuclear cells |
| Dr Tony Mok |
| Dr Michael Boyer |
Sydney Cancer Centre, Royal Prince Alfred Hospital |
| Dr Anthony Chan |
Dept of Clinical Oncology, Chinese University of Hong Kong |
| Dr Alex Chang |
Johns Hopkins Singapore Int Med Centre |
| Dr Stephan Clarke |
Sydney Cancer Centre, Royal Prince Alfred Hospital |
| Dr KC Lam |
Dept of Clinical Oncology, Chinese University of
Hong Kong |
| Dr Ann D King |
Dept of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong |
| Dr Anil T Ahuja |
| Dr Benny Zee |
Dept of Clinical Oncology, Chinese University of
Hong Kong |
| Dr Richard Ambinder |
Sidney Kimmel Comprehensive Cancer Centre at Johns Hopkins Cancer Research, Baltimore |
A Phase I trial of 5- Azacitidine and Suberoylanilide hydroxamic acid in patients with Metastatic or Locally Recurrent Nasopharyngeal Carcinoma and Nasal NK-T cell Lymphoma |
| Dr Anthony Chan |
Dept of Clinical Oncology, Chinese University of Hong Kong |
| Dr Alex Chang |
Johns Hopkins Singapore Int Med Centre |
| Dr Brigette Ma |
Dept of Clinical Oncology, Chinese University of Hong Kong |
| Dr Edwin Hui |
| Dr Qian Tao |
Cancer Epigenetics Lab, Dept of Clinical
Oncology, Chinese University Of Hong Kong |
| Dr Steve Gore |
Sidney Kimmel Comprehensive Cancer Centre at Johns Hopkins Cancer Research, Baltimore |
| Dr Michael Carducci |
| Dr Elizabeth Garrett-Mayer |
Johns Hopkins School of Medicine, Dept of
Oncology, Division of Biostatistics, Baltimore |
|
DR TAN SAY BENG
Senior Biostatistician
|
Dr Steven Julious |
University of Sheffield, UK |
Early phase clinical trials |
| Prof Mike Campbell |
Clinical Trial Designs |
| Prof Peter Fayers |
University of Aberdeen, UK |
Quality of Life Studies |
|
DR GAO FEI
Biostatistician |
Prof David Machin |
United Kingdom Children’s Cancer Study Group, University of Leicester, UK |
Double-peaked mortality risk following mastectomy for breast cancer in Singaporean women: Confirmation of findings from other
regions |
| Prof David Machin |
Kernel smoothing methods |
| Prof David Machin |
Seasonality of lymphomes |
| Prof David Machin |
On the evidence for seasonal variation in the onset
of acute lymphoblastic leukaemia (ALL) |
| Dr Rubert Jakes |
Department of Public Health and Primary Care, University of Cambridge, UK |
Follow-up of the Singapore Breast Screening Project: Efficacy, Disease Progression and Mammographic Density |
| Dr Cheung Yin Bun |
London School of Hygiene and Tropical Medicine, University of London, UK |
Quality of Life research |
| Prof Mini Yu |
Norris Comprehensive Cancer Center, University of Southern California, USA |
Dietary and Genetic Determinants of Mammographic Density |
| |
MS HEE SIEW WAN
Biostatistician |
Prof David Machin |
United Kingdom Children’s Cancer Study Group, University of Leicester, UK |
Phase II oncology trials with time-to-event endpoints |
| |
DR HA TAM CAM
Epidemiologist |
Prof David Machin |
University of Leicester, UK |
Oral Lichen Planus and Squamous Cell Carcinoma |
| Dr Nguyen Ky-Anh |
Biochemistry and Molecular Biology, University
of Georgia, Georgia, USA |