PRINCIPAL INVESTIGATOR/
LABORATORY |
LOCAL COLLABORATORS |
RESEARCH CENTRE |
PROJECT TITLE |
PROF HUI KAM MAN
Bek Chai Heah Laboratory of Cancer Genomics |
Dr Tay Kiang Hiong |
Dept of Diagnostic Radiology, SGH |
Rat as a model system for heart disease |
| Dr Linn Yeh Ching |
Dept of Haematology, SGH |
Immunotherapy of leukemia |
| Dr Chang Guo Ming |
Dept of Orthopaedic Surgery, SingHealth |
Stem cell research |
| Dr Christopher Goh |
Dept of Otolaryngology, SGH |
Nasopharyngeal cancer pathogenesis |
| A/Prof London Lucien Ooi |
Dept of Surgical Oncology, NCCS |
Hepatocellular pathogenesis |
| Dr Ho TH |
KK Women’s & Children’s Hospital |
Gene Expression of ovarian and cervical cancer |
| Dr John Low |
Dept of Radiation Oncology, NCCS |
Nasopharyngeal carcinoma |
| Dr Tan Eng Huat |
Dept of Medical Oncology, NCCS |
Lung Cancer |
| Dr Thomas Gong |
National Technological University |
Diagnostic Imaging |
| Dr Philip Eng |
Respiratory & Critical Care Medicine, SGH |
Lung Cancer |
| Dr Ann Hsu |
Lung cancer genetics |
| A/Prof Philip Cheang |
School of Materials Engineering, Nanyang Technological University |
Nanoparticles for gene delivery |
| |
DR PAULA LAM
Laboratory of Cancer Gene Therapy |
Dr Ng Wai Hoe |
Department of Neurosurgery, NNI |
Gene therapy of gliomas |
| Dr Winston Shim |
National Heart Centre |
Stem cell research |
|
DR GANESAN GOPALAN
Laboratory of Gene Structure & Expression |
Dr Balram Chowbay |
Lab of Clinical Pharmacology, NCCS |
Identification of functional polymorphisms in Aurora-A |
| Dr Ho Gay Hui |
Dept of Surgical Oncology, NCCS |
Epigenetic silencing of Ras-related and estrogenregulated
growth inhibitor (RERG) expression in breast cancer progression |
| |
PROF MALCOLM PATERSON
Laboratory of Genome Maintenance
|
Prof Barry Halliwell |
Office of Life Sciences, NUS |
Relationship between aberrant calcium signaling and state of chronic oxidative stress in ataxia telangiectasia cells |
| Dr Xiao Zhi Cheng |
Dept of Clinical Research, SGH |
Role of ATM protein kinase in learning and memory |
| A/Prof London Lucien Ooi |
Dept of Surgical Oncology, NCCS |
Phosphoproteomic Identification of human tumor signalling susbtrates in vitro and in vivo: comparison with quiescent cells and normal tissues |
| Dr Wong Chow Yin |
Dept of General Surgery, SGH |
| Dr Tan Puay Hoon |
Dept of General Pathology, SGH |
Use of phosphoErbB2 antibodies in molecular pathology |
| Dr Graeme Guy |
Institute of Molecular & Cell Biology |
Signal Transduction of Growth Factors |
| Dr Low Boon Chuan |
Dept of Biological Sciences, NUS |
Signal Transduction |
| Dr Keli Ou |
Proteomics Group, Agenica Pte Ltd |
ICAT and mass spectrometry in functional proteomics |
|
A/PROF HUYNH THE HUNG
Laboratory of Molecular Endocrinology |
A/Prof Lee Seng Teik |
Dept of Plastic Surgery, SGH |
The roles of phyto-chemicals in wound healing and breast, prostate and cervical cancer treatment |
| A/Prof Foo Keong Tatt |
Dept of Urology, SGH |
Finasteride and anti-estrogen in treatment and preventation of prostate cancer |
| Dr Christopher Cheng |
| Dr Tay Sun Kuie |
Dept of Obstetrics & Gynaecology, SGH |
Characterization of a novel tissue associated antigen for uterine and ovarian cancer |
| Prof Soo Khee Chee |
National Cancer Centre Singapore |
Targeting of Insulin-like growth factor system in the treatment and early detection of hepatocellular carcinoma |
| Dr Goh Boon Cher |
National University Hospital |
| Dr Tan Puay Hoon |
Dept of Pathology, SGH |
| Dr Pierce Chow |
Dept of General Surgery, SGH |
| Dr Patrick Tan |
National Cancer Centre Singapore |
Gene expression profile in lung cancer cells treated with flavonoids |
| Prof W.Y. Chan |
Dept of Pharmacology, NUS |
Anti-angiogenesis in Cancer Treatment |
| |
A/PROF PATRICK TAN
Laboratory of Molecular Genomics |
Dr Elaine Lim |
National University of Singapore |
| 1) |
Molecular Genetics of Lung Cancer |
| 2) |
Genomics of Lung Cancer |
|
| A/Prof Hung Huynh |
National Cancer Centre Singapore |
Primary Xenografts of HCC for Cancer Therapeutics |
| A/Prof Manuel Salto Tellez |
National University of Singapore |
| Dr Richie Soong |
| Dr Goh Boon Cher |
National University Hospital |
Pharmacogenomics of Breast Cancer |
| Dr Lee Soo Chin |
| Dr Toh Han Chong |
National Cancer Centre Singapore |
Genomics of T-cell Response |
| Dr Tan Puay Hoon |
Dept of Pathology, SGH |
Molecular Genomics of Breast Cancer |
| A/Prof Nallasivam Palanisamy |
Genome Institute of Singapore |
| Yoshiaki Ito |
Institute of Molecular and Cell Biology |
| Dr Yu Qiang |
Genome Institute of Singapore |
|
A/PROF KANAGA SABAPATHY
Laboratory of Molecular Carcinogenesis |
A/Prof Uttam Surana |
Institute of Molecular & Cell Biology, NUS |
Regulation of Differentiation and Cell Cycle |
| Dr K Swaminathan |
Dept of Biological Sciences, NUS |
Structural analysis of c-Jun & p73 |
| Dr Matthew Whiteman |
Dept of Biochemistry, NUS |
Role of c-Jun pathway in apoptosis |
| A/Prof Alan Porter |
Institute of Molecular & Cell Biology, NUS |
Role of JNKs in apoptosis |
| Dr Phan T |
Dept of Surgery , NUS |
Role of JNKs in epithelial/keratinocyte cell biology |
| Dr Xiao ZC |
Dept of Clinical Research, SGH and IMCB |
Role of JNKs in brain development |
| Dr Li Baojie |
Institute of Molecular & Cell Biology, NUS |
Role of c-Abl & JNK in cellular signalling |
| |
A/PROF KON OI LIAN
Laboratory of Applied Human Genetics |
Dr Patrick Tan |
National Cancer Centre Singapore |
| 1) |
Cancer Genomics & Genetics |
| 2) |
Gene- & cell-based treatment of metabolic diseases |
|
| Dr Mac Ho Meng Fatt |
| Dr Toh Han Chong |
| Dr Dennis T.H. Lim |
Singapore General Hospital |
| Dr Tan Soo Yong |
| Dr Wong Wai Keong |
| Dr Ong Hock Soo |
| Dr Chan Weng Hooong |
| Dr Priyanthi Kumarasinghe |
| Dr Yap Wai Ming |
| Dr Cora Chau |
| Dr Pierce Chow |
| Mr. Robert Ng |
| Dr Ho Liam Pock |
| Dr Tien Sim Leng |
| Dr Lai Siang Hui |
Health Sciences Authority |
| Mr Choo Keng Wah |
Nanyang Polytechnic |
| Mr Steven Yap |
| Dr Joel Lee |
| Dr Nallasivam Palanisamy |
Genome Inst of Singapore |
| Dr Gerald Udolph |
Institute of Bioengineering |
| Dr John Isaac |
NUS Dept of Surgery |
| Cell Research Corporation |
c/o NUS |
Cell-based gene therapy |
| Dr Li Guodong |
NUMI, NUS |
Cell-based diabetes therapy |
| Dr Lim Sai Kiang |
GIS |
| Dr Tony Lim |
Singapore General Hospital |
Gastric cancer genomics/proteomics |
| Dr Lai Siang Hui |
Health Sciences Authority |
Gastric cancer genomics/proteomics; cell-based diabetes therapy |
| Dr Christopher Syn |
Genomics |
|
PROF SOO KHEE CHEE & A/PROF MALINI OLIVO
Tan Chin Tuan Laboratory of Optical Imaging & Photodynamic Therapy |
Asst Prof Ng Beng Koon |
Nanyang Technological University, IEEE |
Fluorescence life-time imaging |
| A/Prof. Subodh Mhaisalkar |
Nanyang Technological University |
Nanotechnology |
| A/Prof Tim White |
Nanyang Technological University, Dept of Materials Sciences |
| Prof YY Gan |
Nanyang Technological University, NIE |
Molecular Photomechanisms |
| A/Prof Bay Boon Huat |
NUS, Anatomy |
In vivo Phosphodynamic Therapy of Hypericin & Hypocrellins |
| A/Prof Paul Heng |
NUS Pharmacy |
New Formulations of Hypericin and Chlorin e6 as a photosensitizer |
| Prof Colin Sheppard |
NUS Bioengineering Department |
Use of Gold Nanoparticles as a molecular specific agent for the prognosis of epithelial cancers in combination with in vivo optical imaging |
| Prof Britton Chance |
SBIC Biopolis |
Biophotonics |
| Dr Weber Lau |
Department of Urology |
Fotolon mediated photodynamic therapy in bladder patients and in in vivo systems |
| Dr Chris Goh |
Dept of Otolaryngology, SGH |
Endoscopy and 2 photon laser confocal fluorescence microscopy of early neoplasia in the oral cavity |
| Dr Tan Puay Hoon |
Dept of Pathology, SGH |
| Dr Kent Mancer |
| Dr Sirajudeen |
Nanyang Technological University, IEEE |
Ex vivo urine cytology using novel photosensitizer Hypericin |
| Prof Frank Watt |
National University of Singapore, Dept of Physics |
Elemental analysis of cultured carcinoma cells and tumour tissue using the NUS nuclear microscope |
| Prof Shen Ze Xiang |
Nanyang Technological University, Mathematics & Physical Sciences |
SERS Nanotechnology and Imaging |
| Prof Seah Hock Soon |
Dean of Computer Engineering, NTU |
| A/Prof Lin Feng |
Computer Engineering, NTU |
| Dr Balram Chowbay |
CTE, National Cancer Centre Singapore |
Photodynamic therapy and anti-angiogenesis |
| Dr Thorsten Wohland |
National University of Singapore |
Fluorescence correlation spectroscopy of hypericin in vitro |
| Prof Dim-Lee Kwong |
Director, Institute of Microelectronics (IME) |
Optical Coherence Tomography |
| A/Prof Poenar Daniel Puiu |
NTU, school of E&EE |
Analysis of biofluids for early cancer detection using miniaturized microdevices such as HPLC and Flowcytometry |
| |
A/PROF ANN LEE
Laboratory of Molecular Oncology |
Dr Peter Ang |
Deparment of Medical Oncology, NCCS |
Mutation spectrum of BRCA1 and BRCA2 |
| Dr Ho Gay Hui |
Department of Surgical Oncology, NCCS |
| Dr Toh Han Chong |
Deparment of Medical Oncology, NCCS |
Molecular analysis of tumors from renal transplant recipients |
| Dr A. Vathsala |
Department of Renal Medicine, SGH |
| Dr Eu Kong Weng |
Department of Colorectal Surgery |
Molecular analysis of colorectal tumours |
| Dr Cheah Peh Yean |
| Dr Victor Lee |
Department of Pathology, SGH |
Molecular analysis of archived tumors |
| Dr Chuah Khoon Leong |
| Dr Tan Puay Hoon |
| Mr. Lee Tze Chuen |
BioInformatics Institute |
Computatonal analysis of mutations |
| Dr Li Kuo Bin |
| A/Prof Vincent Chow |
Department of Microbiology, NUS |
Molecular markers for breast cancer |
| Dr Lai Poh San |
Department of Paediatrics, NUH |
Microsatellite analysis of tumour suppressor genes in cancer |
| Dr Eric Yap |
DMRI |
Novel strategies for detecting gene amplification in cancer |
| Dr Tien Sim Leng |
Division of Cytogenetics, Department of Pathology, SGH |
Array CGH analysis of AML |
| Dr Wong Sin Yew |
Gleneagles Medical Centre |
Molecular studies on Mycobacterium tuberculosis |
| Dr Sun Yong Jiang |
Tan Tock Seng Hospital |
|
A/PROF CAROLINE LEE
Laboratory of Liver Cancer Functional Genomics |
A/Prof London Lucien Ooi |
Liver Cancer Research Laboratory, NCCS |
Functional Genomics of HCC |
| A/Prof Kon Oi Lian |
Lab of Applied Human Genetics, NCCS |
| Dr Tan Soo Yong |
Tan Tock Seng Hospital |
| A/Prof Samuel S. Chong |
Pediatrics Dept, NUS |
Pharmacogenetics and HCC |
| Prof Edmund Lee |
Pharmacology Dept, NUS |
Pharmacogentics of ABC transporters |
| Dr Tan Eng King |
Dept of Neurology, Singapore General Hospital |
Genetics of ABC transporters |
| Dr Ken Sung Wing Kin |
School of Computing, NUS |
Functional Genomics of HCC |
| A/Prof Liu Wen-Tso |
Department of Environmental Science and Engineering |
SNP chips |
| |
A/PROF WONG MENG CHEONG
Brain Tumour Research Laboratory |
Dr Albert Ty |
Dept of Neurology, NNI (SGH) |
Brain tumor stem cell and chemotherapy |
| Dr See Siew Ju |
| Dr Chumpon Chan |
Dept of Neurosurgery, NNI (SGH) |
| Dr John Thomas |
| Dr Yeo Tseng Tsai |
Dept of Neurosurgery, NNI (TTSH) |
| Dr Helmut Rumpel |
Dept of Diagnostic Radiology, SGH |
| Dr Chou Ning |
Dept of Neurosurgery, NUH |
| Dr Elisabeth Cheah |
Dept of Pathology, SGH |
Celecoxib induced glioma necrosis |
| Prof Malcolm Paterson |
Lab of Genome Maintenance, NCCS |
O6-meG genotoxicity and DNA repair (MMR) |
| Dr Ou Keli |
Agenica Research Pte Ltd |
Proteomics identification of MMR complex |
| Dr Ranjiv Sivanandan |
Dept of General Surgery, SGH |
Head & Neck cancer stem cell |
|
DR MAC HO MENG FATT
Laboratory of Oncoproteomics |
Dr Wong Wai Keong |
Dept of General Surgery, SGH |
Gastric Cancer |
| Dr Chan Weng Hoong |
| Dr Ong Hock Soo |
| Prof Yap Wai Ming |
Dept of Pathology, SGH |
| Dr Chau Yuk-Ping |
| Dr Lai Siang Hui |
Health Sciences Authority |
| Prof Roger Beuerman |
Singapore Eye Research Institute |
| Dr Zhou Lei |
| A/Prof Kon Oi Lian |
| Dr Newman Sze |
NTU |
| Dr Tony Lim |
Dept of Pathology, SGH |
| |
DR BALRAM CHOWBAY
Laboratory of Clinical Pharmacology |
Prof Edmund Lee |
Dept of Pharmacology, Faculty of Medicine, NUS |
Pharmacogenetics of drug metabolising enzymes and drug transporters in Asians |
| Dr Tan Eng Huat |
Dept of Medical Oncology, NCCS |
Pharmacogenetics pathways and PK/PD of irinotecan in NPC patients |
| Dr Simon Ong |
Improved individualisation of treatment and dose selection in cancer patients by genotyping |
| A phase I dose-finding study using a chronomodulated dose-intesified (CMDI) regimen of Xeloda and oxaliplatin (XELOX) as either a first- or second-line therapy in patients with advanced metastatic colorectal cancer from a single institution |
| Dr Toh Han Chong |
Pharmacokinetics of cyclosporin A in cancer patients undergoing mini-transplant |
| Dr Peter Ang |
In vivo detection of multidrug resistant phenotype in breast cancer patients for neoadjuvant chemotherapy by scintimammography using 99m Tc-sestamibi scan and genotyping |
| Dr Wong Zee Wan |
A pharmacogenomics study for breast cancer patients undergoing adjuvant chemotherapy with doxorubicin (A)/cyclophosphamide (C) and/or weekly paclitaxel |
| Dr Lee Lai Heng |
Dept of Haematology, SGH |
Influence of genetic polymorphisms in drug metabolising enzymes on warfarin dose and intrinsic clearance in Asian patients |
| Dr William Hwang |
Pharmacokinetics of cyclosporin A and busulphan in cancer patients undergoing mini-transplant |
| Dr Gerard Teoh |
Pharmacokinetics of Zometa in multiple myeloma patients |
| Dr Goh Boon Cher |
Dept of Haematology-Oncology, SGH |
Pharmacogenetics & PKPD profiling of irinotecan in Asian cancer patients |
| A/Prof William Chen Wei Ning |
NTU |
Proteomics profiling in patients receiving anticoagulant therapy |
|
DR JOSEPH WEE
Head, Division of Clinical Trials & Epidemiological Sciences |
Dr Tan Puay Hoon |
Dept of Pathology, SGH |
Randomised Phase II trial of Neoadjuvant weekly Paclitaxel plus Carboplatin compared to weekly Paclitaxel alone, followed in both arms by Doxorubicin and Cyclophosphamide for Operable or Locally Advanced Basal-like subtype Breast Cancer correlating BRCA-1RNA and Protein expression with Carboplatin response. |
| Mr Wong Chow Yin |
Dept of Surgery, SGH |
| Dr Alex Chang |
Dept of Oncology, John Hopkins Int Med Centre, S’pore |
A Phase I Study of Rapamycin in combination with Bevacizumab in patients with Unresectable Hepatocellular Carcinoma |
| A/P Pierce Chow |
Dept of General Surgery, SGH |
| Dr Hsieh Wenson |
Dept of Oncology, John Hopkins Int Med Centre,
S’pore |
| Dr Cheow Peng Chung |
Dept of General Surgery, SGH |
A Phase II trial of Oxaliplatin / Adriamycin / 5 FU in continuous infusion / interferon alfa-2b (OXAFI) combination as neoadjuvant therapy in unresectable non-metastatic hepatocellular carcinoma |
| A/P Pierce Chow |
| Dr Alexander Chung Yaw Fui |
| Dr Law Ngai Moh |
Dept of Int Med, SGH |
| Dr Tan Chee Kiat |
Dept of Gastroenterology, SGH |
| Dr Tan Yu Meng |
Dept of General Surgery, SGH |
| Dr Goh Boon Cher |
Dept of Hematology-Oncology, NUH |
The use of dynamic contrast-enhanced MR imaging (DCE MRI) and dynamic contrastenhanced CT imaging (DCE CT) as a biomarker for effectiveness of anti-angiogenesis therapy. |
| A/P Koh Tong San |
School of Electrical and Electronic Engineering |
| Dr Helmut Rumpel |
Dept of Diagnostic Radiology, SGH |
| Dr Yong Wei Peng |
Dept of Hematology-Oncology, NUH |
| Dr Ross Soo |
| Dr Lee Soo Chin |
| Dr Gan Yu Unn |
Dept of Diagnostic Radiology, SGH |
| Dr Tan Yu Meng |
Dept of Surgical Oncology, NCCS |
A Phase III Randomised study to evaluate Survival of patients treated with Taloporfin Sodium (LS11) and Interstitial Light Emitting Diodes (LED) as compared to the Standard of Care Therapies in the treatment of Unresectable Hepatocellular Carcinoma (HCC) |
| Dr Tan Bien Soo |
Dept of Diagnostic Radiology, SGH |
| Dr Richard Lo |
| Dr Tay Eng Hseon |
Gynecologic Oncology Unit, KKWCH |
Prospective phase II study of neoadjuvant Docetaxel-Cisplatin Chemotherapy followed by concurrent Cisplatin-Radiotherapy in locally advanced cervical cancer |
| Dr Ho Tew Hong |
Dept of Obstetrics & Gynaecology, SGH |
| Dr Tay Sun Kuie |
| Dr A Ilancheran |
Dept of Obstetrics & Gynaecology, NUH |
| Dr Lim Siew Eng |
Dept of Medical Oncology, NUH |
| Dr Benjamin WL Tham |
Gynecologic Oncology Unit, KKWCH |
| Dr Timothy YK Lim |
| A/Prof Christopher Cheng |
Dept of Urology, SGH |
A Phase II Study of Docetaxel plus Carboplatin in chemonaive Hormone-Refractory Prostate Cancer patients |
| Dr Weber Lau |
| |
DR TAN SAY BENG
Senior Biostatistician
|
A/P Saw Seang Mei |
Department of COFM, NUS |
Myopia in Singapore children |
|
DR GAO FEI
Biostatistician |
Dr Eric Lye |
National Dental Centre |
A prospective study on wound healing following extractions in post irradiated jaws |
| |
DR LI HUIHUA
Biostatistician |
Ha Tam Cam |
National Cancer Centre Singapore |
XRCC1 gene polymorphisms and the risk of breast cancer |
| Tai Bee Choo |
National University of Singapore |
RNASEL gene polymorphisms and the risk of prostate cancer |
| |
MS HEE SIEW WAN
Biostatistician |
Tan Say Beng, Tan Sze Huey |
National Cancer Centre Singapore |
Phase II oncology trials with time-to-event endpoints |
| Melissa Teo |
Hepatobiliary Service, Department of Surgery, SGH |
Metastectomy for non-colorectal, nonneuroendocrine liver secondaries |
| Khor Tong Hong |
Mount Elizabeth Oncology Centre, Mount Elizabeth Hospital |
Radical radiotherapy with high-dose rate (HDR) brachtherapy for uterine cervix cancer - long-term results |
|
DR HA TAM CAM
Epidemiologist |
Dr Li Hui Hua |
National Cancer Centre Singapore |
Clodronate and Breast Cancer Survival |
| Dr Poon Choy Yoke |
National Dental Centre |
Oral Lichen Planus and Oral Squamous Cell Carcinoma |
| Dr Peter Ang |
National Cancer Centre Singapore |
Epidemiology of Breast Cancer in Singapore |
| The incidence of axillary lymph node metastases in tumours less than or equal to one centimetre |
| Patterns of Hormone Receptor Status in Asian Women with Breast Cancer |
