Contents

1.

Editorial
   

2.

Diagnosis and management of primary brain tumours

   

3.

Incidentalomas

   

4.

Skin lesions – When to get alarmed?

   

5.

“How to detect thyroid cancers”

   

6.

Radio-iodine therapy for differentiated thyroid carcinoma

   

7.

Amputation
   
 

NCC Tumour Board
Files

   
 

NCC Roundup

   
 

Staff Directory

   
 

www.nccs.com.sg
Reg.No.:199801562Z

We welcome your contributions
to Cancer Update. Send your
queries and comments to
Postgraduate Cancer Education
/Information Support Services,
National Cancer Centre Singapore, 11 Hospital Drive,
Singapore 169610. Or phone us at (65) 6236 9425, fax us at
(65) 6536 5503, or email:
daalff@nccs.com.sg

Ask The Expert
Should you have questions on
cancer treatments, log onto
http://www.nccs.com.sg/ask
/index.htm

for more information.

Please note that contents are not to be quoted or repeated without the permission of the National Cancer Centre. All advice given
in Cancer Update is not intended to replace patient-doctor consultation.

   
   

 

 
NCC Roundup
 
 

Combined Scientific Meeting 2005 -
Shaping a new era in healthcare

Held at Raffles City Convention Centre, 4-6 November, the scientific meeting brought together healthcare practitioners and academic professionals from Singapore's public medical institutions. Foreign and local speakers shared their perspectives and knowledge of new treatment modalities, patient management and service quality. Talks and posters showcased the best of research and clinical practices.

NCC doctors and researchers from the research departments, medical oncology, surgical oncology and radiation oncology participated in the Meeting either by speaking at one of the symposiums, presenting oral papers and by submitting poster presentations in areas such as proteomics, genomics, bioinformatics, molecular imaging of cancer, target identification, gene therapy, telomerase and valuation in cancer drug discovery.

The entire list of oral and poster presentations involving NCC doctors and researchers can be found on NCC's website at http:www.nccs.com.sg

At the symposium – “Showcase of novel developments in oncology”, organised by NCC, leading speakers from both clusters enlightened the audience from topics such as Intensity Modulated Radiation therapy (IMRT)-Improving outcome & reducing toxicity (Dr Joseph Wee, NCC), PET scan-beyond just a imaging tool (Dr Anthony Goh, SGH), Therapeutic monoclonal antibodies (Dr Lim Soon Thye, NCC), Tailor-made oncologic treatment-dissecting the oncologic puzzle: understanding tumor genomics and pharmacogenomics (Prof Malcolm Paterson, Singhealth) and Novel small molecules in oncology (Dr Goh Boon Cher, NUH).

1. Best Singhealth Oral Papers

Evaluation of paperless process in the improvement of efficiency and effectiveness in radiation therapy application. By IJH Lim dept of radiation oncology, NCCS. (S6) under allied health oral papers category.

2. Basic Sciences oral papers

Biochemical characterisation of radiosensitive cell lines derived from adult cancer patients with late radionecrosis SLE long Dept of Radiation Oncology, S Joseph Das (CMR), LS Tay(CMR) Skorsh (CMR), MC paterson (CMR)

Quantitative telomerase by novel OR-PCR technology predicts nodal and distant metastases and prognosis in breast cancer
SKR,Dept of medical oncology

Photodynamic therapy as a promising alternative for palliative treatment of angiosarcoma
PSP Thong, KS Kho, M Olivo (DMS), KC Soo, BKP Goh (SGH surgery)

Amelioration of severe insulin deficiency in a prelinical model of diabetes mellitus by implantation of autologous hepatocytes modified for regulated insulin secretion
NKF Chen, OL Kon – DMS, CH Thng – Dept of radiation oncology, JS WONG Dept of Gen surgery SGH, IHC Kee, RTH Ng - dept of experimental surgery - SGH

3. Singhealth Poster Presentations

An Overview of interventional breast biopsy in the National Cancer Centre
YF Liew, Radiation Oncology, CKK SOR Diagnostic radiology, JBK Khoo diagnostic Imaging

A Novel Exon 13 duplication in the BRAC1 gene identified in a Chinese patient
KPL Yap/ GH Ho, ASG Lee - Surigical onco, P Ang – Medical Onco, IHK Lim - Medical Onco

Temozolomide Induces different checkpoint activation in quiescent and proliferating glioma cells
SW Teng - laboratory, TT Wang, SY Cheng, CJ Zhu - Research divisions(medical sciences), C Chan and A TY, Michael Wong - NNI

Epithelial Cell Transforming Factor 2 (ECT2) promotes glioma cell G1/S cell cycle progression underpinning oncogenicity
TT Wang – Lab Medicine, C Zhu-Medical Sciences, SY Cheng (MS), SW Teng (MS), J Thomas(Neurosurgery), KB Kang(MS), MC Wong(NNI)

Downregulation of P16INK4A Sensitises Siha Cervical Cancer Cells to UV-induced Apoptosis
WM Lau (CMR) TH Ho (SGH, O & G),KM Hui (CMR)

Identification of Tumour-specific Genes by Novel Modified Suppressive Subractive Hybridisation (PP S 69)
BH Liu (CMR), CCGOH(Otolaryngology), LL Ooi(Gen Surgery), D Lim, KM Hui(CMR)

Targeted Gene Therapy with Nanoparticles
K Tan, (CMR), CL Fong (NTU Bioengineering), R Kumar(NTU Bioengineering), P Cheang, Kim Hui (CMR)

Cell Cycle-Regulatable HSV-1 Amplicon viral vector
Y Wang, Law HO, KM Hui, PYP LAM, CMR

Identification of molecular biomarkers associated with the recurrence of human heptocellular carcinomas
SM Wang, LLPJ Ooi, KM Hui, CMR, Surgical Oncology

The rule of epithelial cell transforming factor 2 (ECT2) on DNA Synthesis and S-phase checkpoint activation in glioma cells
SY Cheng, SW Teng, TT Wang, B Liu, A TY, CJ Zhu, MC Wong, Medical Sciences

In Vivo Liver Electroporation: Optimisation and Demonstration of Therapeutic Efficacy
J Sivalingam, OL Kon(Medical Sciences, NCC), STB Yap(Life Sciences, Nanyang Poly), ABM Khoo(NUS), LP Ho, SL Tien(Haematology, SGH)


The National Cancer Centre will be introducing a comprehensive cancer-screening program in December 2005. The majority of cancer patients sadly still present in the late stage where the intent of treatment is no longer curative. To nip cancer in the bud through screening gives the best chance for cure. Hence, “Nip” (Neoplasm Interception Program) – the name of the program. It is unique for its thorough cancer risk evaluation prior to recommendation of a screening program specifically tailored to the individual’s risk profile.

The critical first module of “Nip” is the risk profile ascertainment through detailed history on symptoms, past medical illnesses, personal dietary / social habits, environmental exposure, family history and systemic review. For cancers like breast and colorectal, a specific risk may be determined using validated risk evaluation models. The systematic physical examination will further define specific clinical problems to be addressed. At the end of the first consultation, a risk profile will be assigned and screening tests will be recommended. The results of these tests will be discussed at the follow up review. Subsequent diagnostic procedures and relevant specialist referrals will be arranged if needed. The screening schedule and intervals will be determined based on the respective risk profile.

The “Nip” hotline is 6436 8383 for appointment bookings and general enquires.