Contents
1. The race against breast cancer
   
2.

What's new in breast cancer research?

The truth about Herceptin

   
3.

Radiotherapy in breast cancer treatment

Nuts and bolts of mammography

   
4.

PET-CT in oncology

Role of prophylactic mastectomy in breast cancer

   
5.

Breast conservation and breast reconstruction

Genetics of breast cancer

   
6.

Risk assessment and chemoprevention

Hormone receptors in breast cancer - from bench to bedside

   
  NCC Tumour Board Files
   
  Onco Quiz
   
  NCC Roundup
   
 

Pharmacy Tips

   
  Breast Cancer Overview
   
  Staff Directory
   
  Contact
   

 

 

Top

 

NCC fights SARS with vigilance
 

Question: What are the measures NCC has undertaken to contain SARS?

Dr Khoo:

Protection
The first thing we’ve done is to protect our staff and to some extent also to protect our patients and visitors. We do so by making sure that they don appropriate personal protection equipment depending on which area they work in. For example… at the triage level, they are exposed to unselected patients who have never been screened before – so they are giving full protection (PPE)

At the height of SARS when we need to protect everyone … one can never be sure that the screening is 100%. Almost everyone working in the clinical area is donning the full PPE. And protection extents even to the non-clinical area, where we require people to at least put on a mask.
So these are some of the measures…main idea of protection.

In very high-risk areas, we go beyond that, people even have to wear PAPR (Positive Air Pressure Respirator) if they come into contact with secretions of incubating patients … these are less done in NCC. It’s something that offers an even better protection than N95 mask, cap, gown and gloves.

This prepared for specific situation where the risk of transmission is the highest, for example when you’re operating on a patient or incubating patient, but fortunately we have not had the need to use this so far for a suspect patient. Of course, we’ll continue to use this thing in the operating theatre.

Detection
We have to detect any potential infective patients, and we do so by (using) stringent screening procedures, by asking questions about the travelling history, the contact history, and the symptoms they may have in last 10-14 days. And that’s for patients.

We also have our staff temperature taken three times a day. That’s the attempt to find the earliest possible signs of potential SARS. We know for a fact – there is strong evidence to suggest -- that patients who have contracted SARS do not become infective until they manifest a fever. So fever screening is an effective form of screening and we see that this is done very diligently.

Once you detect them, the idea is to isolate them, and if there is a patient who is a confirmed SARS, we’ll have to isolate them to cut the chain of transmissions. And so with all these 3 measures carried through very diligently, SARS can be brought under control, both for the centre and the community.

Isolation
Isolation is once you detect a patient with probable SARS, suspected SARS, you must quickly isolate the patient -- isolate means to cut him off from the rest of the patients and medical health care workers until the period of infection is over.

Question : Why is it important that we undertake these measures?

Dr Khoo:
These measures will ensure that we minimise the risk of any potential infected patients coming into the centre, and in contact with other patients or health-care workers within the Centre. These measure will minimise infection or to ensure that the chain of transmission can be broken at the earliest opportunity.

Making sure that our staff is adequately protected will give them the confidence and the psychological comfort to continue to work in the Centre, in spite of the fact that this campus does have SARS patients.

Question: Now that Singapore is off the WHO SARS list, what are the measures will NCC continue to implement?

Dr Khoo:

We follow very closely the directives and guidelines, firstly from the Ministry and secondly, from the Outram Campus Taskforce. NCC worked within the framework of the Outram Campus Taskforce which will come up with the policies and guidelines on what sort of measures to take.

Over the last month and a half, some of the stringent measures have been retired and stepped down as the overall situation of SARS in Spore and the rest of the world becomes better. So, some of you may have noticed that doctors working within the outpatient clinic are no longer wearing the full PPE, lest those with very specific situations where the risk of contamination is still exist.


Question: Are cancer patients more prone to catch SARS or to transmit it?

Dr Khoo:

Well, there’s no evidence that cancer patients are more likely to contract SARS or to transmit SARS.
But it is becoming more that apparent patients with chronic illness, who are immuno-suppressed – those with lower immunity, in particular patients with renal diseases, may not manifest the same clinical features as a normal healthy patient. Some of the symptoms may be masked, for example, fever -- they may not have a typical presentation of cough, fever and therefore, it may have gone on undetected for some time before the diagnosis is made. Therefore, now more precautions are taken to isolate these patients whenever there is a slightest suspicion.

Not high risk for contracting SARS, but because they may not manifest SARS in the usual way, and they may have gone undetected. When you’re looking for typical symptoms – fever, cough and bone pain-- they not have any of these things, and yet, they may have already contracted SARS and transmitting SARS.

Although we broadly classify these patients, we think that all immuno-comprised patients and immuno suppressed patients, may be so. But I think evidence is strongest for patients with renal diseases, patients who are on chronic immuno-suppressants. They are on medicine to suppress their immune system with a purpose. For example, patients with a renal transplant – they are taking immune suppressants to prevent rejection. Steroids, which is a very commonly used medicine for a variety of inflammatory diseases, is also one of the culprit.

But to answer that question specifically, no we do not think that cancer patients are more prone to getting SARS. They are just as likely or just as unlikely to get SARS. The only thing that one need to be more aware of is that some of these patients, especially those who are long term immune suppressants may not manifest the usual clinical features.


Question: Fever and coughing are common symptoms of SARS, and these are not uncommon in cancer patients, hence how to make the distinction from SARS?

Dr Khoo:

Well, this is quite right. Fever and coughing are common symptoms of anything from an upper respiratory tract infection to pneumonia. Obviously, not all these are SARS. How one approach this has to do with what the environment is like, and the overall situation with SARS.

At the height of SARS, when there is clear evidence that there’s still local transmission taking place, then one has to make the assumption that any of these patients who present with such a symptom has to be treated as a potential SARS, until proven otherwise. That means -- detection and isolation.

But as the overall SARS situation improved, the likelihood that these are SARS becomes less. So one will have to exercise his judgement. There are certain criteria for people to use to see whether these are likely to be SARS or not.

One, we can fall back again on the history of contact, history of close contact with a SARS patient. For example, either a patient or a person who was home quarantined because of contact with SARS patient, as a health care worker who have been working in a hospital or an environment where SARS was present -- so these are contact history.

Or they have travelled to a SARS affected area or on certain blood test they found that the counts are low which can be SARS…then the index of suspicion must be there. But it’s not always easy because a typical pneumonia is not uncommon, especially in elderly patients.

There is no foolproof way of distinguishing pneumonia from SARS – from other types of pneumonia. So again a very well taken contact history is probably one of the most critical ways to go. Obviously, there are other things that can help us -- the x-ray appearances, the blood test result and now we can do serology of corona virus – we can do PCR to detect the virus in the blood. Some of these tests take time and one may not get the answer immediately. What one may have to do is that in cases where there is suspicion because of contact history, we’ll have to isolate the patient first.

Protection, detection and isolation and be familiar with common symptoms and presentations of SARS, to always take detail contact and travel history and always have a high index of suspicion. So these are the key message.

Then, the other message we can bring across is that NCC has done all the things to ensure that this is a safe environment. The last case that we have was more than … 15 April until now—about 2 ½ months. The last confirmed case of SARS at NCC is more than 2 months ago and since then, we have been named SARS free.

Orange alert – this is for … it’s like an army – whether your alert level is green… means very low—all clear, then yellow, then red.

So the higher the level of alertness, the more stringent the measures to be instituted.

Orange means, yes, things are better, but we still have to be on the lookout… that’s why we have continued to don N95 mask, to continue to screen patients. All patients coming to NCC will have to be screened for temperature. And for those with the fever will be treated in a separate setting, so that they don’t mix with the rest of the patients.


Question: When do we stop doing these things?

Dr Khoo:

We still have to do all these things…the directive of when to stop will have to come from the Ministry. Obviously we are very aware of the potential of SARS raising its head during winter as predicted by many infectious disease expert. Preparing ourselves for any contingency in the event that SARS will come back again.